Effects of prenatal opioid exposure on functional networks in infancy
Prenatal opioid exposure has been linked to altered neurodevelopment and visual problems such as strabismus and nystagmus. The neural substrate underlying these alterations is unclear. Resting-state functional connectivity MRI (rsfMRI) is an advanced and well-established technique to evaluate brain...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-10-01
|
| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929321000864 |
| _version_ | 1818729283577708544 |
|---|---|
| author | Stephanie L. Merhar Weixiong Jiang Nehal A. Parikh Weiyan Yin Zhen Zhou Jean A. Tkach Li Wang Beth M. Kline-Fath Lili He Adebayo Braimah Jennifer Vannest Weili Lin |
| author_facet | Stephanie L. Merhar Weixiong Jiang Nehal A. Parikh Weiyan Yin Zhen Zhou Jean A. Tkach Li Wang Beth M. Kline-Fath Lili He Adebayo Braimah Jennifer Vannest Weili Lin |
| author_sort | Stephanie L. Merhar |
| collection | DOAJ |
| description | Prenatal opioid exposure has been linked to altered neurodevelopment and visual problems such as strabismus and nystagmus. The neural substrate underlying these alterations is unclear. Resting-state functional connectivity MRI (rsfMRI) is an advanced and well-established technique to evaluate brain networks. Few studies have examined the effects of prenatal opioid exposure on resting-state network connectivity in infancy. In this pilot study, we characterized network connectivity in opioid-exposed infants (n = 19) and controls (n = 20) between 4–8 weeks of age using both a whole-brain connectomic approach and a seed-based approach. Prenatal opioid exposure was associated with differences in distribution of betweenness centrality and connection length, with positive connections unique to each group significantly longer than common connections. The unique connections in the opioid-exposed group were more often inter-network connections while unique connections in controls and connections common to both groups were more often intra-network. The opioid-exposed group had smaller network volumes particularly in the primary visual network, but similar network strength as controls. Network topologies as determined by dice similarity index were different between groups, particularly in visual and executive control networks. These results may provide insight into the neural basis for the developmental and visual problems associated with prenatal opioid exposure. |
| first_indexed | 2024-12-17T22:43:26Z |
| format | Article |
| id | doaj.art-c0cac0e7fdca4cf2bf026a7004366983 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-12-17T22:43:26Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-c0cac0e7fdca4cf2bf026a70043669832022-12-21T21:29:52ZengElsevierDevelopmental Cognitive Neuroscience1878-92932021-10-0151100996Effects of prenatal opioid exposure on functional networks in infancyStephanie L. Merhar0Weixiong Jiang1Nehal A. Parikh2Weiyan Yin3Zhen Zhou4Jean A. Tkach5Li Wang6Beth M. Kline-Fath7Lili He8Adebayo Braimah9Jennifer Vannest10Weili Lin11Perinatal Institute, Division of Neonatology, Cincinnati Children’s Hospital and University of Cincinnati, Department of Pediatrics, Cincinnati, OH, USA; Corresponding author at: Perinatal Institute, Cincinnati Children’s Hospital, 3333 Burnet Ave ML 7009, Cincinnati, OH, 45229, USA.Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAPerinatal Institute, Division of Neonatology, Cincinnati Children’s Hospital and University of Cincinnati, Department of Pediatrics, Cincinnati, OH, USADepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAImaging Research Center, Cincinnati Children’s Hospital, Cincinnati, OH, USA; Department of Radiology, Cincinnati Children’s Hospital, Cincinnati, OH, USADepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAImaging Research Center, Cincinnati Children’s Hospital, Cincinnati, OH, USA; Department of Radiology, Cincinnati Children’s Hospital, Cincinnati, OH, USAPerinatal Institute, Division of Neonatology, Cincinnati Children’s Hospital and University of Cincinnati, Department of Pediatrics, Cincinnati, OH, USAImaging Research Center, Cincinnati Children’s Hospital, Cincinnati, OH, USADepartment of Communication Sciences and Disorders, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH, USADepartment of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAPrenatal opioid exposure has been linked to altered neurodevelopment and visual problems such as strabismus and nystagmus. The neural substrate underlying these alterations is unclear. Resting-state functional connectivity MRI (rsfMRI) is an advanced and well-established technique to evaluate brain networks. Few studies have examined the effects of prenatal opioid exposure on resting-state network connectivity in infancy. In this pilot study, we characterized network connectivity in opioid-exposed infants (n = 19) and controls (n = 20) between 4–8 weeks of age using both a whole-brain connectomic approach and a seed-based approach. Prenatal opioid exposure was associated with differences in distribution of betweenness centrality and connection length, with positive connections unique to each group significantly longer than common connections. The unique connections in the opioid-exposed group were more often inter-network connections while unique connections in controls and connections common to both groups were more often intra-network. The opioid-exposed group had smaller network volumes particularly in the primary visual network, but similar network strength as controls. Network topologies as determined by dice similarity index were different between groups, particularly in visual and executive control networks. These results may provide insight into the neural basis for the developmental and visual problems associated with prenatal opioid exposure.http://www.sciencedirect.com/science/article/pii/S1878929321000864NeonatalOpioidNeonatal opioid withdrawal syndromeFunctional MRIFunctional connectivityMagnetic resonance imaging |
| spellingShingle | Stephanie L. Merhar Weixiong Jiang Nehal A. Parikh Weiyan Yin Zhen Zhou Jean A. Tkach Li Wang Beth M. Kline-Fath Lili He Adebayo Braimah Jennifer Vannest Weili Lin Effects of prenatal opioid exposure on functional networks in infancy Developmental Cognitive Neuroscience Neonatal Opioid Neonatal opioid withdrawal syndrome Functional MRI Functional connectivity Magnetic resonance imaging |
| title | Effects of prenatal opioid exposure on functional networks in infancy |
| title_full | Effects of prenatal opioid exposure on functional networks in infancy |
| title_fullStr | Effects of prenatal opioid exposure on functional networks in infancy |
| title_full_unstemmed | Effects of prenatal opioid exposure on functional networks in infancy |
| title_short | Effects of prenatal opioid exposure on functional networks in infancy |
| title_sort | effects of prenatal opioid exposure on functional networks in infancy |
| topic | Neonatal Opioid Neonatal opioid withdrawal syndrome Functional MRI Functional connectivity Magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S1878929321000864 |
| work_keys_str_mv | AT stephanielmerhar effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT weixiongjiang effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT nehalaparikh effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT weiyanyin effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT zhenzhou effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT jeanatkach effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT liwang effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT bethmklinefath effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT lilihe effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT adebayobraimah effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT jennifervannest effectsofprenatalopioidexposureonfunctionalnetworksininfancy AT weililin effectsofprenatalopioidexposureonfunctionalnetworksininfancy |