Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss
Sudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors have been found to affect treatment outcomes. Various...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/19/7248 |
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| author | Jeon Gang Doo Dokyoung Kim Yong Kim Myung Chul Yoo Sung Su Kim Jeewon Ryu Seung Geun Yeo |
| author_facet | Jeon Gang Doo Dokyoung Kim Yong Kim Myung Chul Yoo Sung Su Kim Jeewon Ryu Seung Geun Yeo |
| author_sort | Jeon Gang Doo |
| collection | DOAJ |
| description | Sudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors have been found to affect treatment outcomes. Various studies are being performed to determine the prognosis and effects of treatment in patients who experience sudden hearing loss, and to identify biomarkers associated with this condition. Embase, PubMed, and the Cochrane database were searched using the key words SSNHL, prognostic, and biomarker. This search identified 4 articles in Embase, 28 articles in PubMed, and 36 in the Cochrane database. Of these 68 articles, 3 were duplicates and 37 were unrelated to the research topic. After excluding these articles, the remaining 28 articles were reviewed. Factors associated with SSNHL were divided into six categories: metabolic, hemostatic, inflammatory, immunologic, oxidative, and other factors. The associations between these factors with the occurrence of SSNHL and with patient prognosis were analyzed. Low monocyte counts, low neutrophil/lymphocyte ratio (NLR) and monocyte/high-density lipoproteins (HDL) cholesterol ratio (MHR), and low concentrations of fibrinogen, platelet glycoprotein (GP) IIIa, and TNF-α were found to be associated with good prognosis. However, these factors alone could not completely determine the onset of and recovery from SSNHL, suggesting the need for future basic and clinical studies. |
| first_indexed | 2024-03-10T15:56:14Z |
| format | Article |
| id | doaj.art-c0cac6f4dccb4373b42e96df4b675d33 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:56:14Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c0cac6f4dccb4373b42e96df4b675d332023-11-20T15:42:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012119724810.3390/ijms21197248Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing LossJeon Gang Doo0Dokyoung Kim1Yong Kim2Myung Chul Yoo3Sung Su Kim4Jeewon Ryu5Seung Geun Yeo6Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Physical Medicine & Rehabilitation, School of Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Physical Medicine & Rehabilitation, School of Medicine, Kyung Hee University, Seoul 02447, KoreaMedical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate School, Kyung Hee University, Seoul 02447, KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaSudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors have been found to affect treatment outcomes. Various studies are being performed to determine the prognosis and effects of treatment in patients who experience sudden hearing loss, and to identify biomarkers associated with this condition. Embase, PubMed, and the Cochrane database were searched using the key words SSNHL, prognostic, and biomarker. This search identified 4 articles in Embase, 28 articles in PubMed, and 36 in the Cochrane database. Of these 68 articles, 3 were duplicates and 37 were unrelated to the research topic. After excluding these articles, the remaining 28 articles were reviewed. Factors associated with SSNHL were divided into six categories: metabolic, hemostatic, inflammatory, immunologic, oxidative, and other factors. The associations between these factors with the occurrence of SSNHL and with patient prognosis were analyzed. Low monocyte counts, low neutrophil/lymphocyte ratio (NLR) and monocyte/high-density lipoproteins (HDL) cholesterol ratio (MHR), and low concentrations of fibrinogen, platelet glycoprotein (GP) IIIa, and TNF-α were found to be associated with good prognosis. However, these factors alone could not completely determine the onset of and recovery from SSNHL, suggesting the need for future basic and clinical studies.https://www.mdpi.com/1422-0067/21/19/7248sudden sensorineural hearing lossbiomarkersprognosisrecovery |
| spellingShingle | Jeon Gang Doo Dokyoung Kim Yong Kim Myung Chul Yoo Sung Su Kim Jeewon Ryu Seung Geun Yeo Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss International Journal of Molecular Sciences sudden sensorineural hearing loss biomarkers prognosis recovery |
| title | Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss |
| title_full | Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss |
| title_fullStr | Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss |
| title_full_unstemmed | Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss |
| title_short | Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss |
| title_sort | biomarkers suggesting favorable prognostic outcomes in sudden sensorineural hearing loss |
| topic | sudden sensorineural hearing loss biomarkers prognosis recovery |
| url | https://www.mdpi.com/1422-0067/21/19/7248 |
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