The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin
RepID has previously been shown to promote origin firing. Here the authors reveal that RepID regulates replication origins via the recruitment of the CRL4 complex, and prevents re-initiation and unscheduled DNA replication.
Bibliographic Details
| Main Authors: |
Sang-Min Jang,
Ya Zhang,
Koichi Utani,
Haiqing Fu,
Christophe E. Redon,
Anna B. Marks,
Owen K. Smith,
Catherine J. Redmond,
Adrian M. Baris,
Danielle A. Tulchinsky,
Mirit I. Aladjem |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2018-07-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-018-05177-6
|
|---|