Nanoemulsion Stabilized by Safe Surfactin from <i>Bacillus subtilis</i> as a Multifunctional, Custom-Designed Smart Delivery System
The developing field of bio-nanotechnology aims to advance colloidal research via the introduction of multifunctional nanoparticles to augment the dermal effectiveness of active substances. Self-emulsifying drug delivery systems (SEDDS)—isotropic mixtures of oils, surfactants, solvents and co-solven...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/12/10/953 |
| _version_ | 1797551436786040832 |
|---|---|
| author | Agnieszka Lewińska Marta Domżał-Kędzia Anna Jaromin Marcin Łukaszewicz |
| author_facet | Agnieszka Lewińska Marta Domżał-Kędzia Anna Jaromin Marcin Łukaszewicz |
| author_sort | Agnieszka Lewińska |
| collection | DOAJ |
| description | The developing field of bio-nanotechnology aims to advance colloidal research via the introduction of multifunctional nanoparticles to augment the dermal effectiveness of active substances. Self-emulsifying drug delivery systems (SEDDS)—isotropic mixtures of oils, surfactants, solvents and co-solvents or surfactants—are attracting interest in the cosmeceutical field. As part of this study, SEDDS systems containing vitamin C or vitamin E and curcumin were developed, whereby the bioavailability of the active compounds increased by enhancing their permeability to deeper layers of the skin. A composition consisting of 50% surfactin from <i>Bacillus subtilis</i>, 30% Transcutol and 20% oil phase was designed to encapsulate the active substances, i.e., vitamin C or vitamin E and curcumin, contained in the oil phase. The developed carriers were characterized by average particle sizes of 69–183 nm. The formulations with the vitamins were found to be physically and chemically stable for 6 months. Transdermal tests were carried out, showing that the carriers enable the transport of active substances deep into the skin, stopping at the dermis border. The formulations with vitamin C and vitamin E reduced the discoloration, the vascular lesions, and the depth of the wrinkles on the tested skin, which can be useful in cosmetics in the treatment of problem skin, including capillary and sensitive skin. |
| first_indexed | 2024-03-10T15:44:42Z |
| format | Article |
| id | doaj.art-c0cdaf60af364e87b91df0033a3697ef |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T15:44:42Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-c0cdaf60af364e87b91df0033a3697ef2023-11-20T16:31:34ZengMDPI AGPharmaceutics1999-49232020-10-01121095310.3390/pharmaceutics12100953Nanoemulsion Stabilized by Safe Surfactin from <i>Bacillus subtilis</i> as a Multifunctional, Custom-Designed Smart Delivery SystemAgnieszka Lewińska0Marta Domżał-Kędzia1Anna Jaromin2Marcin Łukaszewicz3Faculty of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383 Wroclaw, PolandDepartment of Biotransformation, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, PolandDepartment of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, PolandDepartment of Biotransformation, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, PolandThe developing field of bio-nanotechnology aims to advance colloidal research via the introduction of multifunctional nanoparticles to augment the dermal effectiveness of active substances. Self-emulsifying drug delivery systems (SEDDS)—isotropic mixtures of oils, surfactants, solvents and co-solvents or surfactants—are attracting interest in the cosmeceutical field. As part of this study, SEDDS systems containing vitamin C or vitamin E and curcumin were developed, whereby the bioavailability of the active compounds increased by enhancing their permeability to deeper layers of the skin. A composition consisting of 50% surfactin from <i>Bacillus subtilis</i>, 30% Transcutol and 20% oil phase was designed to encapsulate the active substances, i.e., vitamin C or vitamin E and curcumin, contained in the oil phase. The developed carriers were characterized by average particle sizes of 69–183 nm. The formulations with the vitamins were found to be physically and chemically stable for 6 months. Transdermal tests were carried out, showing that the carriers enable the transport of active substances deep into the skin, stopping at the dermis border. The formulations with vitamin C and vitamin E reduced the discoloration, the vascular lesions, and the depth of the wrinkles on the tested skin, which can be useful in cosmetics in the treatment of problem skin, including capillary and sensitive skin.https://www.mdpi.com/1999-4923/12/10/953surfactinsurfactant<i>Bacillus subtilis</i>delivery systemnanocarrierskin |
| spellingShingle | Agnieszka Lewińska Marta Domżał-Kędzia Anna Jaromin Marcin Łukaszewicz Nanoemulsion Stabilized by Safe Surfactin from <i>Bacillus subtilis</i> as a Multifunctional, Custom-Designed Smart Delivery System Pharmaceutics surfactin surfactant <i>Bacillus subtilis</i> delivery system nanocarrier skin |
| title | Nanoemulsion Stabilized by Safe Surfactin from <i>Bacillus subtilis</i> as a Multifunctional, Custom-Designed Smart Delivery System |
| title_full | Nanoemulsion Stabilized by Safe Surfactin from <i>Bacillus subtilis</i> as a Multifunctional, Custom-Designed Smart Delivery System |
| title_fullStr | Nanoemulsion Stabilized by Safe Surfactin from <i>Bacillus subtilis</i> as a Multifunctional, Custom-Designed Smart Delivery System |
| title_full_unstemmed | Nanoemulsion Stabilized by Safe Surfactin from <i>Bacillus subtilis</i> as a Multifunctional, Custom-Designed Smart Delivery System |
| title_short | Nanoemulsion Stabilized by Safe Surfactin from <i>Bacillus subtilis</i> as a Multifunctional, Custom-Designed Smart Delivery System |
| title_sort | nanoemulsion stabilized by safe surfactin from i bacillus subtilis i as a multifunctional custom designed smart delivery system |
| topic | surfactin surfactant <i>Bacillus subtilis</i> delivery system nanocarrier skin |
| url | https://www.mdpi.com/1999-4923/12/10/953 |
| work_keys_str_mv | AT agnieszkalewinska nanoemulsionstabilizedbysafesurfactinfromibacillussubtilisiasamultifunctionalcustomdesignedsmartdeliverysystem AT martadomzałkedzia nanoemulsionstabilizedbysafesurfactinfromibacillussubtilisiasamultifunctionalcustomdesignedsmartdeliverysystem AT annajaromin nanoemulsionstabilizedbysafesurfactinfromibacillussubtilisiasamultifunctionalcustomdesignedsmartdeliverysystem AT marcinłukaszewicz nanoemulsionstabilizedbysafesurfactinfromibacillussubtilisiasamultifunctionalcustomdesignedsmartdeliverysystem |