The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia
Spastic muscles are weak muscles. It is known that muscle weakness is linked to poor motor performance. Botulinum neurotoxin (BoNT) injections are considered as the first-line treatment for focal spasticity. The purpose of this study was to quantitatively investigate the effects of BoNT injections o...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/12/8/492 |
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| author | Yen-Ting Chen Chuan Zhang Yang Liu Elaine Magat Monica Verduzco-Gutierrez Gerard E. Francisco Ping Zhou Yingchun Zhang Sheng Li |
| author_facet | Yen-Ting Chen Chuan Zhang Yang Liu Elaine Magat Monica Verduzco-Gutierrez Gerard E. Francisco Ping Zhou Yingchun Zhang Sheng Li |
| author_sort | Yen-Ting Chen |
| collection | DOAJ |
| description | Spastic muscles are weak muscles. It is known that muscle weakness is linked to poor motor performance. Botulinum neurotoxin (BoNT) injections are considered as the first-line treatment for focal spasticity. The purpose of this study was to quantitatively investigate the effects of BoNT injections on force control of spastic biceps brachii muscles in stroke survivors. Ten stroke survivors with spastic hemiplegia (51.7 ± 11.5 yrs; 5 men) who received 100 units of incobotulinumtoxinA or onabotulinumtoxinA to the biceps brachii muscles participated in this study. Spasticity assessment (Modified Ashworth Scale (MAS) and reflex torque) and muscle strength of elbow flexors, as well as motor performance assessment (force variability of submaximal elbow flexion) were performed within one week before (pre-injection) and 3~4 weeks (3-wk) after BoNT injections. As expected, BoNT injections reduced the MAS score and reflex torque, and elbow flexor strength on the spastic paretic side. However, motor performance remained within similar level before and after injections. There was no change in muscle strength or motor performance on the contralateral arm after BoNT injections. The results of this study provide evidence that BoNT injections can reduce spasticity and muscle strength, while motor performance of the weakened spastic muscle remains unchanged. |
| first_indexed | 2024-03-10T18:04:33Z |
| format | Article |
| id | doaj.art-c0ced0f45772459b9bff817f19a8bbe9 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T18:04:33Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-c0ced0f45772459b9bff817f19a8bbe92023-11-20T08:40:11ZengMDPI AGToxins2072-66512020-07-0112849210.3390/toxins12080492The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic HemiplegiaYen-Ting Chen0Chuan Zhang1Yang Liu2Elaine Magat3Monica Verduzco-Gutierrez4Gerard E. Francisco5Ping Zhou6Yingchun Zhang7Sheng Li8Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX 77030, USADepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USADepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USADepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX 77030, USADepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX 77030, USADepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX 77030, USAGuangdong Provincial Work Injury Rehabilitation Center, Guangzhou 510000, ChinaDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USADepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX 77030, USASpastic muscles are weak muscles. It is known that muscle weakness is linked to poor motor performance. Botulinum neurotoxin (BoNT) injections are considered as the first-line treatment for focal spasticity. The purpose of this study was to quantitatively investigate the effects of BoNT injections on force control of spastic biceps brachii muscles in stroke survivors. Ten stroke survivors with spastic hemiplegia (51.7 ± 11.5 yrs; 5 men) who received 100 units of incobotulinumtoxinA or onabotulinumtoxinA to the biceps brachii muscles participated in this study. Spasticity assessment (Modified Ashworth Scale (MAS) and reflex torque) and muscle strength of elbow flexors, as well as motor performance assessment (force variability of submaximal elbow flexion) were performed within one week before (pre-injection) and 3~4 weeks (3-wk) after BoNT injections. As expected, BoNT injections reduced the MAS score and reflex torque, and elbow flexor strength on the spastic paretic side. However, motor performance remained within similar level before and after injections. There was no change in muscle strength or motor performance on the contralateral arm after BoNT injections. The results of this study provide evidence that BoNT injections can reduce spasticity and muscle strength, while motor performance of the weakened spastic muscle remains unchanged.https://www.mdpi.com/2072-6651/12/8/492botulinum toxinspasticitystrokemotor controlforce variabilitymotor performance |
| spellingShingle | Yen-Ting Chen Chuan Zhang Yang Liu Elaine Magat Monica Verduzco-Gutierrez Gerard E. Francisco Ping Zhou Yingchun Zhang Sheng Li The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia Toxins botulinum toxin spasticity stroke motor control force variability motor performance |
| title | The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia |
| title_full | The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia |
| title_fullStr | The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia |
| title_full_unstemmed | The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia |
| title_short | The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia |
| title_sort | effects of botulinum toxin injections on spasticity and motor performance in chronic stroke with spastic hemiplegia |
| topic | botulinum toxin spasticity stroke motor control force variability motor performance |
| url | https://www.mdpi.com/2072-6651/12/8/492 |
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