Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes Meningite bacteriana aguda por Streptococcus pneumoniae resistente aos antimicrobianos e seus sorotipos
The main objectives of this study are to evaluate the resistance rates of Streptococcus pneumonia to penicillin G, ceftriaxone and vancomycin in patients with meningitis; to analyze possible risk factors to the antimicrobian resistance; to describe the serotypes detected and to suggest an initial em...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2008-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000400014 |
| _version_ | 1818027318100099072 |
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| author | Andrea Maciel de Oliveira Rossoni Libera Maria Dalla Costa Denize Bonato Berto Sônia Santos Farah Marilene Gelain Maria Cristina de Cunto Brandileone Vitor Hugo Mariano Ramos Sergio Monteiro de Almeida |
| author_facet | Andrea Maciel de Oliveira Rossoni Libera Maria Dalla Costa Denize Bonato Berto Sônia Santos Farah Marilene Gelain Maria Cristina de Cunto Brandileone Vitor Hugo Mariano Ramos Sergio Monteiro de Almeida |
| author_sort | Andrea Maciel de Oliveira Rossoni |
| collection | DOAJ |
| description | The main objectives of this study are to evaluate the resistance rates of Streptococcus pneumonia to penicillin G, ceftriaxone and vancomycin in patients with meningitis; to analyze possible risk factors to the antimicrobian resistance; to describe the serotypes detected and to suggest an initial empirical treatment for meningitis. The sensitiveness and serotypes of all isolated S. pneumoniae of patients with acute bacterial meningitis received by the Paraná State Central Laboratory from April 2001 to august 2002 have been evaluated. One hundred S. pneumoniae have been isolated, of which 15% were resistant to penicillin, 1% to cephalosporin and 0% to vancomycin. The serotypes most found were 14 (19%), 3 and 23F (10% each). When only the resistant serotypes were analyzed, the most prevalent was the 14 with 44%. The risk factors found in relation to the S. pneumoniae resistance were: age under one year old (p=0.01) and previous use of antibiotic (p=0.046). The resistance rates found, which were moderate to penicillin, low to cephalosporin and neutral to vancomycin, suggest the isolated use of a 3rd generation cephalosporin as an initial empirical therapy for the treatment of acute bacterial meningitis with a communitarian background.<br>Este estudo teve como objetivo avaliar as taxas de resistência de Streptococcus pneumoniae, isolados de pacientes com meningite, à penicilina G, ceftriaxona e vancomicina; avaliar possíveis fatores de risco para resistência antimicrobiana; descrever os sorotipos encontrados e sugerir a terapêutica empírica inicial para meningite. Foram isoladas 100 amostras de S. pneumoniae, encontrando-se 15% de resistência à penicilina, 1% à cefalosporina e 0% à vancomicina. Os sorotipos mais encontrados foram 14 (19%), 3 e 23F (10% cada). Analisando-se os resistentes, o sorotipo 14 (44%) também foi o mais freqüente. Os fatores de risco para resistência de S. pneumoniae encontrados foram: idade menor que um ano (p=0,01) e o uso prévio de antibiótico (p=0,046). As taxas de resistência encontradas, moderada a penicilina, baixa para cefalosporina e nula para vancomicina, sugerem como terapêutica empírica inicial para tratamento da meningite bacteriana aguda de origem comunitária, a cefalosporina de terceira geração isoladamente. |
| first_indexed | 2024-12-10T04:45:59Z |
| format | Article |
| id | doaj.art-c0cf282746e448368a04873acff2762e |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-12-10T04:45:59Z |
| publishDate | 2008-09-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-c0cf282746e448368a04873acff2762e2022-12-22T02:01:46ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272008-09-01663a50951510.1590/S0004-282X2008000400014Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes Meningite bacteriana aguda por Streptococcus pneumoniae resistente aos antimicrobianos e seus sorotiposAndrea Maciel de Oliveira RossoniLibera Maria Dalla CostaDenize Bonato BertoSônia Santos FarahMarilene GelainMaria Cristina de Cunto BrandileoneVitor Hugo Mariano RamosSergio Monteiro de AlmeidaThe main objectives of this study are to evaluate the resistance rates of Streptococcus pneumonia to penicillin G, ceftriaxone and vancomycin in patients with meningitis; to analyze possible risk factors to the antimicrobian resistance; to describe the serotypes detected and to suggest an initial empirical treatment for meningitis. The sensitiveness and serotypes of all isolated S. pneumoniae of patients with acute bacterial meningitis received by the Paraná State Central Laboratory from April 2001 to august 2002 have been evaluated. One hundred S. pneumoniae have been isolated, of which 15% were resistant to penicillin, 1% to cephalosporin and 0% to vancomycin. The serotypes most found were 14 (19%), 3 and 23F (10% each). When only the resistant serotypes were analyzed, the most prevalent was the 14 with 44%. The risk factors found in relation to the S. pneumoniae resistance were: age under one year old (p=0.01) and previous use of antibiotic (p=0.046). The resistance rates found, which were moderate to penicillin, low to cephalosporin and neutral to vancomycin, suggest the isolated use of a 3rd generation cephalosporin as an initial empirical therapy for the treatment of acute bacterial meningitis with a communitarian background.<br>Este estudo teve como objetivo avaliar as taxas de resistência de Streptococcus pneumoniae, isolados de pacientes com meningite, à penicilina G, ceftriaxona e vancomicina; avaliar possíveis fatores de risco para resistência antimicrobiana; descrever os sorotipos encontrados e sugerir a terapêutica empírica inicial para meningite. Foram isoladas 100 amostras de S. pneumoniae, encontrando-se 15% de resistência à penicilina, 1% à cefalosporina e 0% à vancomicina. Os sorotipos mais encontrados foram 14 (19%), 3 e 23F (10% cada). Analisando-se os resistentes, o sorotipo 14 (44%) também foi o mais freqüente. Os fatores de risco para resistência de S. pneumoniae encontrados foram: idade menor que um ano (p=0,01) e o uso prévio de antibiótico (p=0,046). As taxas de resistência encontradas, moderada a penicilina, baixa para cefalosporina e nula para vancomicina, sugerem como terapêutica empírica inicial para tratamento da meningite bacteriana aguda de origem comunitária, a cefalosporina de terceira geração isoladamente.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000400014Streptococcus pneumoniaepneumococomeningiteresistência antimicrobianalíquorStreptococcus pneumoniaepneumococcusmeningitisantimicrobial resistancecerebrospinal fluid |
| spellingShingle | Andrea Maciel de Oliveira Rossoni Libera Maria Dalla Costa Denize Bonato Berto Sônia Santos Farah Marilene Gelain Maria Cristina de Cunto Brandileone Vitor Hugo Mariano Ramos Sergio Monteiro de Almeida Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes Meningite bacteriana aguda por Streptococcus pneumoniae resistente aos antimicrobianos e seus sorotipos Arquivos de Neuro-Psiquiatria Streptococcus pneumoniae pneumococo meningite resistência antimicrobiana líquor Streptococcus pneumoniae pneumococcus meningitis antimicrobial resistance cerebrospinal fluid |
| title | Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes Meningite bacteriana aguda por Streptococcus pneumoniae resistente aos antimicrobianos e seus sorotipos |
| title_full | Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes Meningite bacteriana aguda por Streptococcus pneumoniae resistente aos antimicrobianos e seus sorotipos |
| title_fullStr | Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes Meningite bacteriana aguda por Streptococcus pneumoniae resistente aos antimicrobianos e seus sorotipos |
| title_full_unstemmed | Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes Meningite bacteriana aguda por Streptococcus pneumoniae resistente aos antimicrobianos e seus sorotipos |
| title_short | Acute bacterial meningitis caused by Streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes Meningite bacteriana aguda por Streptococcus pneumoniae resistente aos antimicrobianos e seus sorotipos |
| title_sort | acute bacterial meningitis caused by streptococcus pneumoniae resistant to the antimicrobian agents and their serotypes meningite bacteriana aguda por streptococcus pneumoniae resistente aos antimicrobianos e seus sorotipos |
| topic | Streptococcus pneumoniae pneumococo meningite resistência antimicrobiana líquor Streptococcus pneumoniae pneumococcus meningitis antimicrobial resistance cerebrospinal fluid |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2008000400014 |
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