Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies

The increasing prevalence and severity of pediatric food allergies (FA) demands innovative preventive and therapeutic strategies. Emerging evidence suggests a pivotal role for the gut microbiome in modulating susceptibility to FA. Studies have demonstrated that alteration of gut microbiome could pre...

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Main Authors: Margherita Di Costanzo, Laura Carucci, Roberto Berni Canani, Giacomo Biasucci
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/15/5275
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author Margherita Di Costanzo
Laura Carucci
Roberto Berni Canani
Giacomo Biasucci
author_facet Margherita Di Costanzo
Laura Carucci
Roberto Berni Canani
Giacomo Biasucci
author_sort Margherita Di Costanzo
collection DOAJ
description The increasing prevalence and severity of pediatric food allergies (FA) demands innovative preventive and therapeutic strategies. Emerging evidence suggests a pivotal role for the gut microbiome in modulating susceptibility to FA. Studies have demonstrated that alteration of gut microbiome could precede FA, and that particular microbial community structures early in life could influence also the disease course. The identification of gut microbiome features in pediatric FA patients is driving new prevention and treatment approaches. This review is focused on the potential role of the gut microbiome as a target for FA prevention and treatment.
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spelling doaj.art-c0d07bcd49e946beafc363741a23d4972023-11-20T07:55:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012115527510.3390/ijms21155275Gut Microbiome Modulation for Preventing and Treating Pediatric Food AllergiesMargherita Di Costanzo0Laura Carucci1Roberto Berni Canani2Giacomo Biasucci3Department of Pediatrics and Neonatology, Guglielmo da Saliceto Hospital, 29121 Piacenza, ItalyDepartment of Translational Medical Science-Pediatric Section, University “Federico II”, 80131 Naples, ItalyDepartment of Translational Medical Science-Pediatric Section, University “Federico II”, 80131 Naples, ItalyDepartment of Pediatrics and Neonatology, Guglielmo da Saliceto Hospital, 29121 Piacenza, ItalyThe increasing prevalence and severity of pediatric food allergies (FA) demands innovative preventive and therapeutic strategies. Emerging evidence suggests a pivotal role for the gut microbiome in modulating susceptibility to FA. Studies have demonstrated that alteration of gut microbiome could precede FA, and that particular microbial community structures early in life could influence also the disease course. The identification of gut microbiome features in pediatric FA patients is driving new prevention and treatment approaches. This review is focused on the potential role of the gut microbiome as a target for FA prevention and treatment.https://www.mdpi.com/1422-0067/21/15/5275gut microbiomefood allergydysbiosis
spellingShingle Margherita Di Costanzo
Laura Carucci
Roberto Berni Canani
Giacomo Biasucci
Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies
International Journal of Molecular Sciences
gut microbiome
food allergy
dysbiosis
title Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies
title_full Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies
title_fullStr Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies
title_full_unstemmed Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies
title_short Gut Microbiome Modulation for Preventing and Treating Pediatric Food Allergies
title_sort gut microbiome modulation for preventing and treating pediatric food allergies
topic gut microbiome
food allergy
dysbiosis
url https://www.mdpi.com/1422-0067/21/15/5275
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AT lauracarucci gutmicrobiomemodulationforpreventingandtreatingpediatricfoodallergies
AT robertobernicanani gutmicrobiomemodulationforpreventingandtreatingpediatricfoodallergies
AT giacomobiasucci gutmicrobiomemodulationforpreventingandtreatingpediatricfoodallergies