Finger extensor variability in TMS parameters among chronic stroke patients
<p>Abstract</p> <p>Background</p> <p>This study determined the reliability of topographic motor cortical maps and MEP characteristics in the extensor digitorum communis (EDC) evoked by single-pulse TMS among patients with chronic stroke.</p> <p>Methods</p...
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| Format: | Article |
| Language: | English |
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BMC
2005-05-01
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| Series: | Journal of NeuroEngineering and Rehabilitation |
| Subjects: | |
| Online Access: | http://www.jneuroengrehab.com/content/2/1/10 |
| _version_ | 1828419344915234816 |
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| author | Kahn Shannon Wolf Steven L Butler Andrew J Weiss Paul |
| author_facet | Kahn Shannon Wolf Steven L Butler Andrew J Weiss Paul |
| author_sort | Kahn Shannon |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>This study determined the reliability of topographic motor cortical maps and MEP characteristics in the extensor digitorum communis (EDC) evoked by single-pulse TMS among patients with chronic stroke.</p> <p>Methods</p> <p>Each of ten patients was studied on three occasions. Measures included location of the EDC hotspot and center of gravity (COG), threshold of activation and average amplitude of the hotspot, number of active sites, map volume, and recruitment curve (RC) slope.</p> <p>Results</p> <p>Consistent intrahemispheric measurements were obtained for the three TMS mapping sessions for all measured variables. No statistically significant difference was observed between hemispheres for the number of active sites, COG distance or the RC slope. The magnitude and range of COG movement between sessions were similar to those reported previously with this muscle in able-bodied individuals. The average COG movement over three sessions in both hemispheres was 0.90 cm. The average COG movement in the affected hemisphere was 1.13 (± 0.08) cm, and 0.68 (± 0.04) cm) for the less affected hemisphere. However, significant interhemispheric variability was seen for the average MEP amplitude, normalized map volume, and resting motor threshold.</p> <p>Conclusion</p> <p>The physiologic variability in some TMS measurements of EDC suggest that interpretation of TMS mapping data derived from hemiparetic patients in the chronic stage following stroke should be undertaken cautiously. Irrespective of the muscle, potential causes of variability should be resolved to accurately assess the impact of pharmacological or physical interventions on cortical organization as measured by TMS among patients with stroke.</p> |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1743-0003 |
| language | English |
| last_indexed | 2024-12-10T14:51:39Z |
| publishDate | 2005-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of NeuroEngineering and Rehabilitation |
| spelling | doaj.art-c0d1b1b7f0d84b9e838d8da55ad436b12022-12-22T01:44:26ZengBMCJournal of NeuroEngineering and Rehabilitation1743-00032005-05-01211010.1186/1743-0003-2-10Finger extensor variability in TMS parameters among chronic stroke patientsKahn ShannonWolf Steven LButler Andrew JWeiss Paul<p>Abstract</p> <p>Background</p> <p>This study determined the reliability of topographic motor cortical maps and MEP characteristics in the extensor digitorum communis (EDC) evoked by single-pulse TMS among patients with chronic stroke.</p> <p>Methods</p> <p>Each of ten patients was studied on three occasions. Measures included location of the EDC hotspot and center of gravity (COG), threshold of activation and average amplitude of the hotspot, number of active sites, map volume, and recruitment curve (RC) slope.</p> <p>Results</p> <p>Consistent intrahemispheric measurements were obtained for the three TMS mapping sessions for all measured variables. No statistically significant difference was observed between hemispheres for the number of active sites, COG distance or the RC slope. The magnitude and range of COG movement between sessions were similar to those reported previously with this muscle in able-bodied individuals. The average COG movement over three sessions in both hemispheres was 0.90 cm. The average COG movement in the affected hemisphere was 1.13 (± 0.08) cm, and 0.68 (± 0.04) cm) for the less affected hemisphere. However, significant interhemispheric variability was seen for the average MEP amplitude, normalized map volume, and resting motor threshold.</p> <p>Conclusion</p> <p>The physiologic variability in some TMS measurements of EDC suggest that interpretation of TMS mapping data derived from hemiparetic patients in the chronic stage following stroke should be undertaken cautiously. Irrespective of the muscle, potential causes of variability should be resolved to accurately assess the impact of pharmacological or physical interventions on cortical organization as measured by TMS among patients with stroke.</p>http://www.jneuroengrehab.com/content/2/1/10motor mappingreliabilitycenter of gravityupper limbplasticityrehabilitationcortex |
| spellingShingle | Kahn Shannon Wolf Steven L Butler Andrew J Weiss Paul Finger extensor variability in TMS parameters among chronic stroke patients Journal of NeuroEngineering and Rehabilitation motor mapping reliability center of gravity upper limb plasticity rehabilitation cortex |
| title | Finger extensor variability in TMS parameters among chronic stroke patients |
| title_full | Finger extensor variability in TMS parameters among chronic stroke patients |
| title_fullStr | Finger extensor variability in TMS parameters among chronic stroke patients |
| title_full_unstemmed | Finger extensor variability in TMS parameters among chronic stroke patients |
| title_short | Finger extensor variability in TMS parameters among chronic stroke patients |
| title_sort | finger extensor variability in tms parameters among chronic stroke patients |
| topic | motor mapping reliability center of gravity upper limb plasticity rehabilitation cortex |
| url | http://www.jneuroengrehab.com/content/2/1/10 |
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