Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines
Summary: Next-generation vaccines may be delivered via the skin and mucosa. The stratified squamous epithelium (SSE) represents the outermost layer of the skin (epidermis) and type II mucosa (epithelium). Langerhans cells (LCs) have been considered the sole antigen-presenting cells (APCs) to inhabit...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221112472400305X |
| _version_ | 1797249171486408704 |
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| author | Erica Elizabeth Vine Paul Jonathon Austin Thomas Ray O’Neil Najla Nasr Kirstie Melissa Bertram Anthony Lawrence Cunningham Andrew Nicholas Harman |
| author_facet | Erica Elizabeth Vine Paul Jonathon Austin Thomas Ray O’Neil Najla Nasr Kirstie Melissa Bertram Anthony Lawrence Cunningham Andrew Nicholas Harman |
| author_sort | Erica Elizabeth Vine |
| collection | DOAJ |
| description | Summary: Next-generation vaccines may be delivered via the skin and mucosa. The stratified squamous epithelium (SSE) represents the outermost layer of the skin (epidermis) and type II mucosa (epithelium). Langerhans cells (LCs) have been considered the sole antigen-presenting cells (APCs) to inhabit the SSE; however, it is now clear that dendritic cells (DCs) are also present. Importantly, there are functional differences in how LCs and DCs take up and process pathogens as well as their ability to activate and polarize T cells, though whether DCs participate in neuroimmune interactions like LCs is yet to be elucidated. A correct definition and functional characterization of APCs in the skin and anogenital tissues are of utmost importance for the design of better vaccines and blocking pathogen transmission. Here, we provide a historical perspective on the evolution of our understanding of the APCs that inhabit the SSE, including a detailed review of the most recent literature. |
| first_indexed | 2024-04-24T20:26:15Z |
| format | Article |
| id | doaj.art-c0d22c2785c440fcb48fd547a91ce575 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-24T20:26:15Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-c0d22c2785c440fcb48fd547a91ce5752024-03-22T05:39:13ZengElsevierCell Reports2211-12472024-04-01434113977Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccinesErica Elizabeth Vine0Paul Jonathon Austin1Thomas Ray O’Neil2Najla Nasr3Kirstie Melissa Bertram4Anthony Lawrence Cunningham5Andrew Nicholas Harman6Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; Westmead Clinic School, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW 2145, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia; Brain and Mind Centre, University of Sydney, Camperdown, NSW 2050, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, AustraliaCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia; Corresponding authorSummary: Next-generation vaccines may be delivered via the skin and mucosa. The stratified squamous epithelium (SSE) represents the outermost layer of the skin (epidermis) and type II mucosa (epithelium). Langerhans cells (LCs) have been considered the sole antigen-presenting cells (APCs) to inhabit the SSE; however, it is now clear that dendritic cells (DCs) are also present. Importantly, there are functional differences in how LCs and DCs take up and process pathogens as well as their ability to activate and polarize T cells, though whether DCs participate in neuroimmune interactions like LCs is yet to be elucidated. A correct definition and functional characterization of APCs in the skin and anogenital tissues are of utmost importance for the design of better vaccines and blocking pathogen transmission. Here, we provide a historical perspective on the evolution of our understanding of the APCs that inhabit the SSE, including a detailed review of the most recent literature.http://www.sciencedirect.com/science/article/pii/S221112472400305XCP: Immunology |
| spellingShingle | Erica Elizabeth Vine Paul Jonathon Austin Thomas Ray O’Neil Najla Nasr Kirstie Melissa Bertram Anthony Lawrence Cunningham Andrew Nicholas Harman Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines Cell Reports CP: Immunology |
| title | Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines |
| title_full | Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines |
| title_fullStr | Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines |
| title_full_unstemmed | Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines |
| title_short | Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines |
| title_sort | epithelial dendritic cells vs langerhans cells implications for mucosal vaccines |
| topic | CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S221112472400305X |
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