The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older.
Serum cytokines and C-reactive protein (CRP) are known as one of the major risk factors in atherosclerosis. The antioxidant and anti-inflammatory properties of zinc have been suggested, but few data are available on the relationship between zinc status and inflammatory markers in epidemiological stu...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4469681?pdf=render |
| _version_ | 1828375564680953856 |
|---|---|
| author | Sukyoung Jung Mi Kyung Kim Bo Youl Choi |
| author_facet | Sukyoung Jung Mi Kyung Kim Bo Youl Choi |
| author_sort | Sukyoung Jung |
| collection | DOAJ |
| description | Serum cytokines and C-reactive protein (CRP) are known as one of the major risk factors in atherosclerosis. The antioxidant and anti-inflammatory properties of zinc have been suggested, but few data are available on the relationship between zinc status and inflammatory markers in epidemiological studies.The present study aims to investigate the cross-sectional relationships of serum cytokines and CRP with dietary zinc intake and serum zinc levels in healthy men and women aged 40 and older in rural areas of South Korea.A group of 1,055 subjects (404 men, 651 women) was included in dietary zinc analysis while another group of 695 subjects (263 men, 432 women) was included in serum zinc analysis. Serum IL-6, TNF-α, and CRP were measured as inflammatory markers.There was no significant inverse relationship between dietary zinc intake and inflammatory markers. We found a significant inverse relationship between serum zinc levels and all three inflammatory markers in women (P for trend = 0.0236 for IL-6; P for trend = 0.0017 for TNF-α; P for trend = 0.0301 for CRP) and between serum zinc levels and a single inflammatory marker (IL-6) in men (P for trend = 0.0191), although all R2 values by regression were less than 10%.In conclusion, serum zinc levels may be inversely related to inflammatory markers (IL-6, TNF-α, and CRP), particularly in women. |
| first_indexed | 2024-04-14T07:49:11Z |
| format | Article |
| id | doaj.art-c0d27eeea2164639a9bc89fa0b40e15b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T07:49:11Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c0d27eeea2164639a9bc89fa0b40e15b2022-12-22T02:05:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e013001610.1371/journal.pone.0130016The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older.Sukyoung JungMi Kyung KimBo Youl ChoiSerum cytokines and C-reactive protein (CRP) are known as one of the major risk factors in atherosclerosis. The antioxidant and anti-inflammatory properties of zinc have been suggested, but few data are available on the relationship between zinc status and inflammatory markers in epidemiological studies.The present study aims to investigate the cross-sectional relationships of serum cytokines and CRP with dietary zinc intake and serum zinc levels in healthy men and women aged 40 and older in rural areas of South Korea.A group of 1,055 subjects (404 men, 651 women) was included in dietary zinc analysis while another group of 695 subjects (263 men, 432 women) was included in serum zinc analysis. Serum IL-6, TNF-α, and CRP were measured as inflammatory markers.There was no significant inverse relationship between dietary zinc intake and inflammatory markers. We found a significant inverse relationship between serum zinc levels and all three inflammatory markers in women (P for trend = 0.0236 for IL-6; P for trend = 0.0017 for TNF-α; P for trend = 0.0301 for CRP) and between serum zinc levels and a single inflammatory marker (IL-6) in men (P for trend = 0.0191), although all R2 values by regression were less than 10%.In conclusion, serum zinc levels may be inversely related to inflammatory markers (IL-6, TNF-α, and CRP), particularly in women.http://europepmc.org/articles/PMC4469681?pdf=render |
| spellingShingle | Sukyoung Jung Mi Kyung Kim Bo Youl Choi The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older. PLoS ONE |
| title | The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older. |
| title_full | The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older. |
| title_fullStr | The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older. |
| title_full_unstemmed | The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older. |
| title_short | The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older. |
| title_sort | relationship between zinc status and inflammatory marker levels in rural korean adults aged 40 and older |
| url | http://europepmc.org/articles/PMC4469681?pdf=render |
| work_keys_str_mv | AT sukyoungjung therelationshipbetweenzincstatusandinflammatorymarkerlevelsinruralkoreanadultsaged40andolder AT mikyungkim therelationshipbetweenzincstatusandinflammatorymarkerlevelsinruralkoreanadultsaged40andolder AT boyoulchoi therelationshipbetweenzincstatusandinflammatorymarkerlevelsinruralkoreanadultsaged40andolder AT sukyoungjung relationshipbetweenzincstatusandinflammatorymarkerlevelsinruralkoreanadultsaged40andolder AT mikyungkim relationshipbetweenzincstatusandinflammatorymarkerlevelsinruralkoreanadultsaged40andolder AT boyoulchoi relationshipbetweenzincstatusandinflammatorymarkerlevelsinruralkoreanadultsaged40andolder |