Treatment of alcoholic liver disease
Alcoholic liver disease (ALD) remains a major cause of liver-related mortality in the US and worldwide. The correct diagnosis of ALD can usually be made on a clinical basis in conjunction with blood tests, and a liver biopsy is not usually required. Abstinence is the hallmark of therapy for ALD, and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2011-01-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/1756283X10378925 |
| _version_ | 1818200042187522048 |
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| author | Thomas H. Frazier MD Abigail M. Stocker MD Nicole A. Kershner MD Luis S. Marsano MD Craig J. McClain MD |
| author_facet | Thomas H. Frazier MD Abigail M. Stocker MD Nicole A. Kershner MD Luis S. Marsano MD Craig J. McClain MD |
| author_sort | Thomas H. Frazier MD |
| collection | DOAJ |
| description | Alcoholic liver disease (ALD) remains a major cause of liver-related mortality in the US and worldwide. The correct diagnosis of ALD can usually be made on a clinical basis in conjunction with blood tests, and a liver biopsy is not usually required. Abstinence is the hallmark of therapy for ALD, and nutritional therapy is the first line of therapeutic intervention. The role of steroids in patients with moderate to severe alcoholic hepatitis is gaining increasing acceptance, with the caveat that patients be evaluated for the effectiveness of therapy at 1 week. Pentoxifylline appears to be especially effective in ALD patients with renal dysfunction/hepatorenal syndrome. Biologics such as specific anti-TNFs have been disappointing and should probably not be used outside of the clinical trial setting. Transplantation is effective in patients with end-stage ALD who have stopped drinking (usually for ≥6 months), and both long-term graft and patient survival are excellent. |
| first_indexed | 2024-12-12T02:31:22Z |
| format | Article |
| id | doaj.art-c0d3744c1f5249699c5daa1bd9e34f32 |
| institution | Directory Open Access Journal |
| issn | 1756-283X 1756-2848 |
| language | English |
| last_indexed | 2024-12-12T02:31:22Z |
| publishDate | 2011-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-c0d3744c1f5249699c5daa1bd9e34f322022-12-22T00:41:24ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-283X1756-28482011-01-01410.1177/1756283X10378925Treatment of alcoholic liver diseaseThomas H. Frazier MDAbigail M. Stocker MDNicole A. Kershner MDLuis S. Marsano MDCraig J. McClain MDAlcoholic liver disease (ALD) remains a major cause of liver-related mortality in the US and worldwide. The correct diagnosis of ALD can usually be made on a clinical basis in conjunction with blood tests, and a liver biopsy is not usually required. Abstinence is the hallmark of therapy for ALD, and nutritional therapy is the first line of therapeutic intervention. The role of steroids in patients with moderate to severe alcoholic hepatitis is gaining increasing acceptance, with the caveat that patients be evaluated for the effectiveness of therapy at 1 week. Pentoxifylline appears to be especially effective in ALD patients with renal dysfunction/hepatorenal syndrome. Biologics such as specific anti-TNFs have been disappointing and should probably not be used outside of the clinical trial setting. Transplantation is effective in patients with end-stage ALD who have stopped drinking (usually for ≥6 months), and both long-term graft and patient survival are excellent.https://doi.org/10.1177/1756283X10378925 |
| spellingShingle | Thomas H. Frazier MD Abigail M. Stocker MD Nicole A. Kershner MD Luis S. Marsano MD Craig J. McClain MD Treatment of alcoholic liver disease Therapeutic Advances in Gastroenterology |
| title | Treatment of alcoholic liver disease |
| title_full | Treatment of alcoholic liver disease |
| title_fullStr | Treatment of alcoholic liver disease |
| title_full_unstemmed | Treatment of alcoholic liver disease |
| title_short | Treatment of alcoholic liver disease |
| title_sort | treatment of alcoholic liver disease |
| url | https://doi.org/10.1177/1756283X10378925 |
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