A pain reflex-inspired hydrogel for refractory wound healing
Promoting refractory wound healing remains a major therapeutic challenge. Here, a pain reflex-inspired hydrogel responsive to inflammatory microenvironmental conditions was developed and used to treat chronically infected diabetic wounds. This material was produced by reacting ε-Polylysine, which ex...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Materials & Design |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127522006086 |
| _version_ | 1828356117023948800 |
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| author | Chuan Guo Yu Wang Haoyang Song Weilong Li Qingquan Kong Ye Wu |
| author_facet | Chuan Guo Yu Wang Haoyang Song Weilong Li Qingquan Kong Ye Wu |
| author_sort | Chuan Guo |
| collection | DOAJ |
| description | Promoting refractory wound healing remains a major therapeutic challenge. Here, a pain reflex-inspired hydrogel responsive to inflammatory microenvironmental conditions was developed and used to treat chronically infected diabetic wounds. This material was produced by reacting ε-Polylysine, which exhibits antibacterial properties, with oxidized hyaluronic acid to yield a dynamic Schiff base-crosslinked hydrogel capable of undergoing triggered dissociation in response to the lower microenvironmental pH found within refractory wounds. This hydrogel exhibited intrinsic antimicrobial activity owing to the incorporation of ε-Polylysine within the hydrogel network. To imbue the hydrogel with low pH-inducible anti-inflammatory and angiogenic activity, Schiff base bonds were used to capture Deferoxamine (DFO)-loaded amino-functionalized mesoporous silica nanoparticles (MSNs-NH2@DFO) on this hydrogel skeleton. The reflexive behaviors of the hydrogel make it ideally suited to facilitating wound healing in response to excessive local inflammation. The resultant intelligent hydrogel was highly biocompatible and exhibited robust antibacterial, anti-inflammatory, and pro-angiogenic activity in vitro and in vivo, thus effectively promoting the healing of chronically infected diabetic wounds. This novel hydrogel therefore holds great promise as a tool to promote refractory wound healing. |
| first_indexed | 2024-04-14T02:53:58Z |
| format | Article |
| id | doaj.art-c0d43ca52ddd48b8877689b774c2050d |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-14T02:53:58Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-c0d43ca52ddd48b8877689b774c2050d2022-12-22T02:16:12ZengElsevierMaterials & Design0264-12752022-09-01221110986A pain reflex-inspired hydrogel for refractory wound healingChuan Guo0Yu Wang1Haoyang Song2Weilong Li3Qingquan Kong4Ye Wu5Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaOrthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaOrthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaOrthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaCorresponding authors.; Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaCorresponding authors.; Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaPromoting refractory wound healing remains a major therapeutic challenge. Here, a pain reflex-inspired hydrogel responsive to inflammatory microenvironmental conditions was developed and used to treat chronically infected diabetic wounds. This material was produced by reacting ε-Polylysine, which exhibits antibacterial properties, with oxidized hyaluronic acid to yield a dynamic Schiff base-crosslinked hydrogel capable of undergoing triggered dissociation in response to the lower microenvironmental pH found within refractory wounds. This hydrogel exhibited intrinsic antimicrobial activity owing to the incorporation of ε-Polylysine within the hydrogel network. To imbue the hydrogel with low pH-inducible anti-inflammatory and angiogenic activity, Schiff base bonds were used to capture Deferoxamine (DFO)-loaded amino-functionalized mesoporous silica nanoparticles (MSNs-NH2@DFO) on this hydrogel skeleton. The reflexive behaviors of the hydrogel make it ideally suited to facilitating wound healing in response to excessive local inflammation. The resultant intelligent hydrogel was highly biocompatible and exhibited robust antibacterial, anti-inflammatory, and pro-angiogenic activity in vitro and in vivo, thus effectively promoting the healing of chronically infected diabetic wounds. This novel hydrogel therefore holds great promise as a tool to promote refractory wound healing.http://www.sciencedirect.com/science/article/pii/S0264127522006086Biomimetic hydrogelReflexive behaviorsAnti-inflammationAngiogenesisWound |
| spellingShingle | Chuan Guo Yu Wang Haoyang Song Weilong Li Qingquan Kong Ye Wu A pain reflex-inspired hydrogel for refractory wound healing Materials & Design Biomimetic hydrogel Reflexive behaviors Anti-inflammation Angiogenesis Wound |
| title | A pain reflex-inspired hydrogel for refractory wound healing |
| title_full | A pain reflex-inspired hydrogel for refractory wound healing |
| title_fullStr | A pain reflex-inspired hydrogel for refractory wound healing |
| title_full_unstemmed | A pain reflex-inspired hydrogel for refractory wound healing |
| title_short | A pain reflex-inspired hydrogel for refractory wound healing |
| title_sort | pain reflex inspired hydrogel for refractory wound healing |
| topic | Biomimetic hydrogel Reflexive behaviors Anti-inflammation Angiogenesis Wound |
| url | http://www.sciencedirect.com/science/article/pii/S0264127522006086 |
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