Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent?
Breast cancer (BC) is the most commonly diagnosed malignancy in women worldwide as well as the leading cause of cancer-related death in this gender. Studies have identified that human papillomavirus (HPV) is a potential risk factor for BC development. While vaccines that protect against oncogenic HP...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/10/8/804 |
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| author | Rancés Blanco Diego Carrillo-Beltrán Juan P. Muñoz Alejandro H. Corvalán Gloria M. Calaf Francisco Aguayo |
| author_facet | Rancés Blanco Diego Carrillo-Beltrán Juan P. Muñoz Alejandro H. Corvalán Gloria M. Calaf Francisco Aguayo |
| author_sort | Rancés Blanco |
| collection | DOAJ |
| description | Breast cancer (BC) is the most commonly diagnosed malignancy in women worldwide as well as the leading cause of cancer-related death in this gender. Studies have identified that human papillomavirus (HPV) is a potential risk factor for BC development. While vaccines that protect against oncogenic HPVs infection have been commercially available, global disparities persist due to their high cost. Interestingly, numerous authors have detected an increased high risk (HR)-HPV infection in BC specimens when compared with non-tumor tissues. Therefore, it was suggested that HR-HPV infection could play a role in breast carcinogenesis in a subset of cases. Additional epidemiological and experimental evidence is still needed regarding the role of HR-HPV infection in the development and progression of BC. |
| first_indexed | 2024-03-10T09:00:44Z |
| format | Article |
| id | doaj.art-c0d4c0b4f4444b26826017615a60179f |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T09:00:44Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-c0d4c0b4f4444b26826017615a60179f2023-11-22T06:50:45ZengMDPI AGBiology2079-77372021-08-0110880410.3390/biology10080804Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent?Rancés Blanco0Diego Carrillo-Beltrán1Juan P. Muñoz2Alejandro H. Corvalán3Gloria M. Calaf4Francisco Aguayo5Programa de Virología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 8380000, ChilePrograma de Virología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago 8380000, ChileInstituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, ChileAdvanced Center for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile, Santiago 8320000, ChileInstituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, ChileUniversidad de Tarapacá, Arica 1000000, ChileBreast cancer (BC) is the most commonly diagnosed malignancy in women worldwide as well as the leading cause of cancer-related death in this gender. Studies have identified that human papillomavirus (HPV) is a potential risk factor for BC development. While vaccines that protect against oncogenic HPVs infection have been commercially available, global disparities persist due to their high cost. Interestingly, numerous authors have detected an increased high risk (HR)-HPV infection in BC specimens when compared with non-tumor tissues. Therefore, it was suggested that HR-HPV infection could play a role in breast carcinogenesis in a subset of cases. Additional epidemiological and experimental evidence is still needed regarding the role of HR-HPV infection in the development and progression of BC.https://www.mdpi.com/2079-7737/10/8/804breasthuman papillomaviruscancer |
| spellingShingle | Rancés Blanco Diego Carrillo-Beltrán Juan P. Muñoz Alejandro H. Corvalán Gloria M. Calaf Francisco Aguayo Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent? Biology breast human papillomavirus cancer |
| title | Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent? |
| title_full | Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent? |
| title_fullStr | Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent? |
| title_full_unstemmed | Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent? |
| title_short | Human Papillomavirus in Breast Carcinogenesis: A Passenger, a Cofactor, or a Causal Agent? |
| title_sort | human papillomavirus in breast carcinogenesis a passenger a cofactor or a causal agent |
| topic | breast human papillomavirus cancer |
| url | https://www.mdpi.com/2079-7737/10/8/804 |
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