Characterization of a Pan-Immunoglobulin Assay Quantifying Antibodies Directed against the Receptor Binding Domain of the SARS-CoV-2 S1-Subunit of the Spike Protein: A Population-Based Study

Characterization of a Pan-Immunoglobulin Assay Quantifying Antibodies Directed against the Receptor Binding Domain of the SARS-CoV-2 S1-Subunit of the Spike Protein: A Population-Based Study

Pan-immunoglobulin assays can simultaneously detect IgG, IgM and IgA directed against the receptor binding domain (RBD) of the S1 subunit of the spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 S1-RBD Ig). In this work, we aim to evaluate a quantitative SARS-CoV-2 S1-...

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Bibliographic Details
Main Authors: Anna Schaffner, Lorenz Risch, Stefanie Aeschbacher, Corina Risch, Myriam C. Weber, Sarah L. Thiel, Katharina Jüngert, Michael Pichler, Kirsten Grossmann, Nadia Wohlwend, Thomas Lung, Dorothea Hillmann, Susanna Bigler, Thomas Bodmer, Mauro Imperiali, Harald Renz, Philipp Kohler, Pietro Vernazza, Christian R. Kahlert, Raphael Twerenbold, Matthias Paprotny, David Conen, Martin Risch
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Journal of Clinical Medicine
Subjects:
area under the curve
coronavirus
COVID-19
diagnostic accuracy
immunoassay
predictive values
Online Access:https://www.mdpi.com/2077-0383/9/12/3989

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