Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicity
Background: In the recent years, the prevalence of metal-induced toxicity, especially leadinduced toxicity, has increased considerably. Metals including lead cause oxidative stress. Therefore Rheum ribes L. as a medicinal plant with antioxidant activity may reduce the complications of these toxiciti...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2018-04-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-7-83.pdf |
| _version_ | 1797828000803192832 |
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| author | Shirin Asgharian Hasan Hoseinkhani Elham Bijad Zahra Lorigooini Mahmoud Rafieian-Kopaei |
| author_facet | Shirin Asgharian Hasan Hoseinkhani Elham Bijad Zahra Lorigooini Mahmoud Rafieian-Kopaei |
| author_sort | Shirin Asgharian |
| collection | DOAJ |
| description | Background: In the recent years, the prevalence of metal-induced toxicity, especially leadinduced toxicity, has increased considerably. Metals including lead cause oxidative stress. Therefore Rheum ribes L. as a medicinal plant with antioxidant activity may reduce the complications of these toxicities. Objectives: The aim of the current study was to investigate the protective effect of hydroalcoholic R. ribes L. extract in male rat model of lead acetate-induced nephrotoxicity. Materials and Methods: In this experimental study, 40 male Wistar rats were randomly assigned to four groups: Normal saline (control) group, positive control group treated with 0.6 g/L/d of lead acetate in drinking water, and two R. ribes groups treated with 200 and 400 mg/kg/d of R. ribes extract in addition to lead acetate for 10 days. After treatment, the rats were anesthetized, blood samples were taken, and kidneys were removed and fixed in 10% formalin. Then, serum antioxidant capacity was measured and kidney tissue specimens histopathologically studied. Results: Serum antioxidant capacity was significantly different between lead acetate group and the group treated with lead acetate + R. ribes extract (400 mg/kg). Additionally mice receiving lead acetate + R. ribes extract (400 mg/kg) had significantly higher antioxidant capacity than the control group (P<0.05). Treatment of lead acetate-treated rats with R. ribes extract significantly prevented damage to their kidney tissues. Conclusions: Rheum ribes extract can prevent lead-induced kidney damage, and therefore exposure to lead acetate by people are recommended to consume this extract. |
| first_indexed | 2024-04-09T12:57:28Z |
| format | Article |
| id | doaj.art-c0d70f6db1dd4b8c890452dd499d6e82 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:57:28Z |
| publishDate | 2018-04-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-c0d70f6db1dd4b8c890452dd499d6e822023-05-13T11:29:42ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192018-04-0172838710.15171/jnp.2018.20jnp-20180425174100Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicityShirin Asgharian0Hasan Hoseinkhani1Elham Bijad2Zahra Lorigooini3Mahmoud Rafieian-Kopaei4Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranMedical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, IranBackground: In the recent years, the prevalence of metal-induced toxicity, especially leadinduced toxicity, has increased considerably. Metals including lead cause oxidative stress. Therefore Rheum ribes L. as a medicinal plant with antioxidant activity may reduce the complications of these toxicities. Objectives: The aim of the current study was to investigate the protective effect of hydroalcoholic R. ribes L. extract in male rat model of lead acetate-induced nephrotoxicity. Materials and Methods: In this experimental study, 40 male Wistar rats were randomly assigned to four groups: Normal saline (control) group, positive control group treated with 0.6 g/L/d of lead acetate in drinking water, and two R. ribes groups treated with 200 and 400 mg/kg/d of R. ribes extract in addition to lead acetate for 10 days. After treatment, the rats were anesthetized, blood samples were taken, and kidneys were removed and fixed in 10% formalin. Then, serum antioxidant capacity was measured and kidney tissue specimens histopathologically studied. Results: Serum antioxidant capacity was significantly different between lead acetate group and the group treated with lead acetate + R. ribes extract (400 mg/kg). Additionally mice receiving lead acetate + R. ribes extract (400 mg/kg) had significantly higher antioxidant capacity than the control group (P<0.05). Treatment of lead acetate-treated rats with R. ribes extract significantly prevented damage to their kidney tissues. Conclusions: Rheum ribes extract can prevent lead-induced kidney damage, and therefore exposure to lead acetate by people are recommended to consume this extract.https://nephropathol.com/PDF/jnp-7-83.pdfrheum ribes l.lead acetatenephrotoxicityantioxidant capacitymetal-induced toxicity |
| spellingShingle | Shirin Asgharian Hasan Hoseinkhani Elham Bijad Zahra Lorigooini Mahmoud Rafieian-Kopaei Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicity Journal of Nephropathology rheum ribes l. lead acetate nephrotoxicity antioxidant capacity metal-induced toxicity |
| title | Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicity |
| title_full | Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicity |
| title_fullStr | Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicity |
| title_full_unstemmed | Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicity |
| title_short | Protective effect of hydroalcoholic Rheum ribes L. extract in male rat model of lead acetate-induced nephrotoxicity |
| title_sort | protective effect of hydroalcoholic rheum ribes l extract in male rat model of lead acetate induced nephrotoxicity |
| topic | rheum ribes l. lead acetate nephrotoxicity antioxidant capacity metal-induced toxicity |
| url | https://nephropathol.com/PDF/jnp-7-83.pdf |
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