Dogs as Sentinels for Flavivirus Exposure in Urban, Peri-Urban and Rural Hanoi, Vietnam
Diseases caused by flaviviruses, including dengue fever and Japanese encephalitis, are major health problems in Vietnam. This cross-sectional study explored the feasibility of domestic dogs as sentinels to better understand risks of mosquito-borne diseases in Hanoi city. A total of 475 dogs serum sa...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/3/507 |
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| author | Long Pham-Thanh Thang Nguyen-Tien Ulf Magnusson Vuong Bui-Nghia Anh Bui-Ngoc Duy Le-Thanh Åke Lundkvist Minh Can-Xuan Thuy Nguyen-Thi Thu Hau Vu-Thi Bich Hu Suk Lee Hung Nguyen-Viet Johanna Lindahl |
| author_facet | Long Pham-Thanh Thang Nguyen-Tien Ulf Magnusson Vuong Bui-Nghia Anh Bui-Ngoc Duy Le-Thanh Åke Lundkvist Minh Can-Xuan Thuy Nguyen-Thi Thu Hau Vu-Thi Bich Hu Suk Lee Hung Nguyen-Viet Johanna Lindahl |
| author_sort | Long Pham-Thanh |
| collection | DOAJ |
| description | Diseases caused by flaviviruses, including dengue fever and Japanese encephalitis, are major health problems in Vietnam. This cross-sectional study explored the feasibility of domestic dogs as sentinels to better understand risks of mosquito-borne diseases in Hanoi city. A total of 475 dogs serum samples from 221 households in six districts of Hanoi were analyzed by a competitive enzyme-linked immunosorbent assay (cELISA) for antibodies to the pr-E protein of West Nile virus and other flaviviruses due to cross-reactivity. The overall flavivirus seroprevalence in the dog population was 70.7% (95% CI = 66.4–74.8%). At the animal level, significant associations between seropositive dogs and district location, age, breed and keeping practice were determined. At the household level, the major risk factors were rural and peri-urban locations, presence of pigs, coil burning and households without mosquito-borne disease experience (<i>p</i> < 0.05). Mosquito control by using larvicides or electric traps could lower seropositivity, but other measures did not contribute to significant risk mitigation of flavivirus exposure in dogs. These results will support better control of mosquito-borne diseases in Hanoi, and they indicate that dogs can be used as sentinels for flavivirus exposure. |
| first_indexed | 2024-03-10T13:06:09Z |
| format | Article |
| id | doaj.art-c0d8dab5845b4ae18bc800dbab5ea0b8 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T13:06:09Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-c0d8dab5845b4ae18bc800dbab5ea0b82023-11-21T11:07:24ZengMDPI AGViruses1999-49152021-03-0113350710.3390/v13030507Dogs as Sentinels for Flavivirus Exposure in Urban, Peri-Urban and Rural Hanoi, VietnamLong Pham-Thanh0Thang Nguyen-Tien1Ulf Magnusson2Vuong Bui-Nghia3Anh Bui-Ngoc4Duy Le-Thanh5Åke Lundkvist6Minh Can-Xuan7Thuy Nguyen-Thi Thu8Hau Vu-Thi Bich9Hu Suk Lee10Hung Nguyen-Viet11Johanna Lindahl12International Livestock Research Institute (ILRI), Hanoi 10000, VietnamInternational Livestock Research Institute (ILRI), Hanoi 10000, VietnamDepartment of Clinical Sciences, Swedish University of Agricultural Sciences, 75123 Uppsala, SwedenNational Institute for Veterinary Research, Hanoi 10000, VietnamNational Institute for Veterinary Research, Hanoi 10000, VietnamNational Institute for Veterinary Research, Hanoi 10000, VietnamDepartment of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, SwedenHanoi Sub-Department of Livestock Production and Animal Health, Hanoi 10000, VietnamNational Institute for Hygiene and Epidemiology, Hanoi 10000, VietnamNational Institute for Hygiene and Epidemiology, Hanoi 10000, VietnamInternational Livestock Research Institute (ILRI), Hanoi 10000, VietnamInternational Livestock Research Institute (ILRI), Hanoi 10000, VietnamInternational Livestock Research Institute (ILRI), Hanoi 10000, VietnamDiseases caused by flaviviruses, including dengue fever and Japanese encephalitis, are major health problems in Vietnam. This cross-sectional study explored the feasibility of domestic dogs as sentinels to better understand risks of mosquito-borne diseases in Hanoi city. A total of 475 dogs serum samples from 221 households in six districts of Hanoi were analyzed by a competitive enzyme-linked immunosorbent assay (cELISA) for antibodies to the pr-E protein of West Nile virus and other flaviviruses due to cross-reactivity. The overall flavivirus seroprevalence in the dog population was 70.7% (95% CI = 66.4–74.8%). At the animal level, significant associations between seropositive dogs and district location, age, breed and keeping practice were determined. At the household level, the major risk factors were rural and peri-urban locations, presence of pigs, coil burning and households without mosquito-borne disease experience (<i>p</i> < 0.05). Mosquito control by using larvicides or electric traps could lower seropositivity, but other measures did not contribute to significant risk mitigation of flavivirus exposure in dogs. These results will support better control of mosquito-borne diseases in Hanoi, and they indicate that dogs can be used as sentinels for flavivirus exposure.https://www.mdpi.com/1999-4915/13/3/507dogsmosquito-borne flavivirusseroprevalenceHanoiVietnam |
| spellingShingle | Long Pham-Thanh Thang Nguyen-Tien Ulf Magnusson Vuong Bui-Nghia Anh Bui-Ngoc Duy Le-Thanh Åke Lundkvist Minh Can-Xuan Thuy Nguyen-Thi Thu Hau Vu-Thi Bich Hu Suk Lee Hung Nguyen-Viet Johanna Lindahl Dogs as Sentinels for Flavivirus Exposure in Urban, Peri-Urban and Rural Hanoi, Vietnam Viruses dogs mosquito-borne flavivirus seroprevalence Hanoi Vietnam |
| title | Dogs as Sentinels for Flavivirus Exposure in Urban, Peri-Urban and Rural Hanoi, Vietnam |
| title_full | Dogs as Sentinels for Flavivirus Exposure in Urban, Peri-Urban and Rural Hanoi, Vietnam |
| title_fullStr | Dogs as Sentinels for Flavivirus Exposure in Urban, Peri-Urban and Rural Hanoi, Vietnam |
| title_full_unstemmed | Dogs as Sentinels for Flavivirus Exposure in Urban, Peri-Urban and Rural Hanoi, Vietnam |
| title_short | Dogs as Sentinels for Flavivirus Exposure in Urban, Peri-Urban and Rural Hanoi, Vietnam |
| title_sort | dogs as sentinels for flavivirus exposure in urban peri urban and rural hanoi vietnam |
| topic | dogs mosquito-borne flavivirus seroprevalence Hanoi Vietnam |
| url | https://www.mdpi.com/1999-4915/13/3/507 |
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