Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Because of poor solubility and considerable metabolism, vardenafil (VRD) bioavailability is 15%. To overcome this obstacle, this study aimed to increase the solubility, hasten the onset of action, and mask the unpleasant taste of VRD utilizing β-cyclodextrin (β-CD) and formulation...

Full description

Bibliographic Details
Main Authors:	Hytham A. Al-Gethmy, Usama A. Fahmy, Nabil A. Alhakamy, Osama A. A. Ahmed, Khalid M. El-Say
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Series:	Pharmaceutics
Subjects:	bioavailability Box–Behnken design β-cyclodextrin erectile dysfunction taste masking vardenafil
Online Access:	http://www.mdpi.com/1999-4923/11/1/11

Similar Items

Vardenafil for the treatment of erectile dysfunction: an overview of the clinical evidence
by: Antonio Martín Morales, et al.
Published: (2009-12-01)

Optimized Taste-Masked Microparticles for Orally Disintegrating Tablets as a Promising Dosage Form for Alzheimer’s Disease Patients
by: Lalinthip Sutthapitaksakul, et al.
Published: (2021-07-01)

Influence of regular use of vardenafil on endothelial and erectile functions in patients with arteriogenic erectile dysfunction
by: Safar Israilovich Gamidov, et al.
Published: (2009-10-01)

REVITALISE: A Large Observational Study Assessing the Safety and Effectiveness of Vardenafil in Men With Erectile Dysfunction and Metabolic Syndrome
by: Ridwan Shabsigh, MD, FACS, et al.
Published: (2016-09-01)

Isolation and identification of a novel vardenafil analogue, propoxy-vardenafil, found as an adulterant in a health supplement
by: Jian Sun, et al.
Published: (2023-06-01)

Impact of penile rehabilitation with low-dose vardenafil on recovery of erectile function in Japanese men following nerve-sparing radical prostatectomy
by: Yuzo Nakano, et al.
Published: (2014-12-01)

Vardenafil Reduces Testicular Damage Following Ischemia/Reperfusion Injury in Rats
by: Bulent Erol, et al.
Published: (2009-07-01)

High Dose Vardenafil Blunts the Hypertensive Effects of Toll-Like Receptor 3 Activation During Pregnancy
by: Dakshnapriya Balasubbramanian, et al.
Published: (2021-12-01)

Spectrophotometric Analysis of Vardenafil in Tablet Dosage Forms by Using Electrophilic Coupling Reagents
by: Atkuru Veera Venkata Naga Krishna Kumar, et al.
Published: (2016-06-01)

Vardenafil Activity in Lung Fibrosis and In Vitro Synergy with Nintedanib
by: Michael H. Bourne, et al.
Published: (2021-12-01)

Experimental substantiation of an opportunity of the use of vardenafil for pharmacological preconditioning in surgery
by: I. M. Kolesnik, et al.
Published: (2015-04-01)

Pediatric Orally Disintegrating Tablets (ODTs) with Enhanced Palatability Based on Propranolol HCl Coground with Hydroxypropyl-β-Cyclodextrin
by: Marzia Cirri, et al.
Published: (2024-10-01)

Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction
by: Fayez O. Alotaibi, et al.
Published: (2020-12-01)

The effects of vardenafil and pentoxifylline administration in an animal model of ischemic colitis
by: Mehmet Aziret, et al.
Published: (2014-11-01)

Efficacy and safety of silodosin, vardenafil versus silodosin in combination with vardenafil as a medical expulsive therapy for distal ureteric stones: a prospective randomized double-blind study
by: Mohamed Samir, et al.
Published: (2020-07-01)

Vardenafil Enhances Oxytocin Expression in the Paraventricular Nucleus without Sexual Stimulation
by: Mal Soon Shin, et al.
Published: (2010-12-01)

Vardenafil Oral Dispersible Films (ODFs) with Advanced Dissolution, Palatability, and Bioavailability
by: Heba A. Abou-Taleb, et al.
Published: (2022-02-01)

Vardenafil Long-Term Administration Improves Episodic Memory in Aging Female Mice
by: Harold Dadomo, et al.
Published: (2023-11-01)

Thermodynamic protonation constants of vardenafil by the nonlinear regression of multiwavelength pH-spectrophotometric titration data
by: Meloun Milan, et al.
Published: (2013-02-01)

A novel vardenafil analog in a healthcare product: Preparation, characterization, and quantification
by: Jintao Xia, et al.
Published: (2023-09-01)

PVC membrane, coated-wire, and carbon-paste electrodes for potentiometric determination of vardenafil hydrochloride in tablet formulations and urine samples
by: Hazem M. Abu Shawish, et al.
Published: (2022-01-01)

Combinations of Freeze-Dried Amorphous Vardenafil Hydrochloride with Saccharides as a Way to Enhance Dissolution Rate and Permeability
by: Gabriela Wiergowska, et al.
Published: (2021-05-01)

Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on esophageal motility: a systematic review
by: Arman Shafiee, et al.
Published: (2023-05-01)

Ethosome-Derived Invasomes as a Potential Transdermal Delivery System for Vardenafil Hydrochloride: Development, Optimization and Application of Physiologically Based Pharmacokinetic Modeling in Adults and Geriatrics
by: Ammar HO, et al.
Published: (2020-08-01)

Anti-Inflammatory Effects of Vardenafil Against Cholestatic Liver Damage in Mice: a Mechanistic Study
by: Dina S. El-Agamy, et al.
Published: (2018-05-01)

Fast disintegrating tablets: Opportunity in drug delivery system
by: Ved Parkash, et al.
Published: (2011-01-01)

Formulation and Optimization of Avanafil Biodegradable Polymeric Nanoparticles: A Single-Dose Clinical Pharmacokinetic Evaluation
by: Hibah M. Aldawsari, et al.
Published: (2020-06-01)

CORRECTION CHRONIC ISCHEMIA FINITE COMBINATION OF VARDENAFIL AND PENTOXIFYLLINE EXPERIMENT
by: K. I. Lavrinenko, et al.
Published: (2016-10-01)

Evolution of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction in Taiwan
by: Bang-Ping Jiann
Published: (2016-06-01)

Recent Formulation Advances and Therapeutic Usefulness of Orally Disintegrating Tablets (ODTs)
by: Maimoona Chinwala
Published: (2020-10-01)

Thermal Analysis Investigation of Dapoxetine and Vardenafil Hydrochlorides using Molecular Orbital Calculations
by: Ali Kamal Attia, et al.
Published: (2015-11-01)

Vardenafil oral jellies as a potential approach for management of pediatric irritable bowel syndrome
by: Eman Gomaa, et al.
Published: (2021-09-01)

Optimized Icariin Cubosomes Exhibit Augmented Cytotoxicity against SKOV-3 Ovarian Cancer Cells
by: Usama A. Fahmy, et al.
Published: (2020-12-01)

Optimized furosemide taste masked orally disintegrating tablets
by: Mohamed Abbas Ibrahim, et al.
Published: (2017-11-01)

Quality-by-design based fabrication of febuxostat-loaded nanoemulsion: Statistical optimization, characterizations, permeability, and bioavailability studies
by: Vishal C. Gurumukhi, et al.
Published: (2023-04-01)

Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement
by: Chunzheng Li, et al.
Published: (2023-04-01)

Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells
by: Barbara Dhooghe, et al.
Published: (2020-08-01)

Design and optimization of DPC-crosslinked HPβCD nanosponges for entrectinib oral delivery: formulation, characterization, and pharmacokinetic studies
by: Konda Sri Chaya Reddy, et al.
Published: (2024-08-01)

Self-Nanoemulsifying System Loaded with Sildenafil Citrate and Incorporated within Oral Lyophilized Flash Tablets: Preparation, Optimization, and In Vivo Evaluation
by: Khaled M. Hosny, et al.
Published: (2020-11-01)

Self-Nanoemulsion Loaded with a Combination of Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment
by: Khaled M. Hosny, et al.
Published: (2020-12-01)