Gestational Leucylation Suppresses Embryonic T‐Box Transcription Factor 5 Signal and Causes Congenital Heart Disease

Gestational Leucylation Suppresses Embryonic T‐Box Transcription Factor 5 Signal and Causes Congenital Heart Disease

Abstract Dysregulated maternal nutrition, such as vitamin deficiencies and excessive levels of glucose and fatty acids, increases the risk for congenital heart disease (CHD) in the offspring. However, the association between maternal amino‐acid levels and CHD is unclear. Here, it is shown that incre...

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Những tác giả chính: Xuan Zhang, Lian Liu, Wei‐Cheng Chen, Feng Wang, Yi‐Rong Cheng, Yi‐Meng Liu, Yang‐Fan Lai, Rui‐Jia Zhang, Ya‐Nan Qiao, Yi‐Yuan Yuan, Yan Lin, Wei Xu, Jing Cao, Yong‐Hao Gui, Jian‐Yuan Zhao
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Wiley 2022-05-01
Loạt:Advanced Science
Những chủ đề:
congenital heart disease
gestational amino acid levels
leucine
lysine‐leucylation
TBX5 signal
Truy cập trực tuyến:https://doi.org/10.1002/advs.202201034

Internet

https://doi.org/10.1002/advs.202201034

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