Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review
High blood glucose levels are a hallmark of the metabolic syndrome known as diabetes mellitus. More than 600 million people will have diabetes by 2045 as the global prevalence of the disease continues to rise. Contemporary antidiabetic drugs reduce hyperglycemia and its consequences. However, these...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402400238X |
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| author | Naiyer Shahzad Abdullah R. Alzahrani Ibrahim Abdel Aziz Ibrahim Imran Shahid Ibrahim M. Alanazi Alaa Hisham Falemban Mohammad Tarique Imam Nehal Mohsin Mohd Fahami Nur Azlina Palanisamy Arulselvan |
| author_facet | Naiyer Shahzad Abdullah R. Alzahrani Ibrahim Abdel Aziz Ibrahim Imran Shahid Ibrahim M. Alanazi Alaa Hisham Falemban Mohammad Tarique Imam Nehal Mohsin Mohd Fahami Nur Azlina Palanisamy Arulselvan |
| author_sort | Naiyer Shahzad |
| collection | DOAJ |
| description | High blood glucose levels are a hallmark of the metabolic syndrome known as diabetes mellitus. More than 600 million people will have diabetes by 2045 as the global prevalence of the disease continues to rise. Contemporary antidiabetic drugs reduce hyperglycemia and its consequences. However, these drugs come with undesirable side effects, so it's encouraging that research into plant extracts and bioactive substances with antidiabetic characteristics is on the rise. Natural remedies are preferable to conventional anti-diabetic drugs since they are safer for the body, more affordable and have fewer potential adverse effects. Biological macromolecules such as liposomes, niosomes, polymeric nanoparticles, solid lipid nanoparticles, nanoemulsions and metallic nanoparticles are explored in this review. Current drug restrictions have been addressed, and the effectiveness of plant-based antidiabetic therapies has enhanced the merits of these methods. Plant extracts' loading capacity and the carriers' stability are the primary obstacles in developing plant-based nanocarriers. Hydrophilic, hydrophobic, and amphiphilic drugs are covered, and a brief overview of the amphipathic features of liposomes, phospholipids, and lipid nanocarriers is provided. Metallic nanoparticles' benefits and attendant risks are highlighted to emphasize their efficiency in treating hyperglycemia. Researchers interested in the potential of nanoparticles loaded with plant extracts as antidiabetic therapeutics may find the current helpful review. |
| first_indexed | 2024-03-08T06:56:17Z |
| format | Article |
| id | doaj.art-c0da52fe1c7649d4a8f6364a43f6b4a4 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:56:17Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-c0da52fe1c7649d4a8f6364a43f6b4a42024-02-03T06:36:31ZengElsevierHeliyon2405-84402024-01-01102e24207Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic reviewNaiyer Shahzad0Abdullah R. Alzahrani1Ibrahim Abdel Aziz Ibrahim2Imran Shahid3Ibrahim M. Alanazi4Alaa Hisham Falemban5Mohammad Tarique Imam6Nehal Mohsin7Mohd Fahami Nur Azlina8Palanisamy Arulselvan9Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; Corresponding author.Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi ArabiaDepartment of Clinical Pharmacy, Faculty of Pharmacy, Najran University, Najran, Saudi ArabiaDepartment of Pharmacology, Faculty of Medicine, Universiti Kebangsaan, MalaysiaDepartment of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, 602 105, IndiaHigh blood glucose levels are a hallmark of the metabolic syndrome known as diabetes mellitus. More than 600 million people will have diabetes by 2045 as the global prevalence of the disease continues to rise. Contemporary antidiabetic drugs reduce hyperglycemia and its consequences. However, these drugs come with undesirable side effects, so it's encouraging that research into plant extracts and bioactive substances with antidiabetic characteristics is on the rise. Natural remedies are preferable to conventional anti-diabetic drugs since they are safer for the body, more affordable and have fewer potential adverse effects. Biological macromolecules such as liposomes, niosomes, polymeric nanoparticles, solid lipid nanoparticles, nanoemulsions and metallic nanoparticles are explored in this review. Current drug restrictions have been addressed, and the effectiveness of plant-based antidiabetic therapies has enhanced the merits of these methods. Plant extracts' loading capacity and the carriers' stability are the primary obstacles in developing plant-based nanocarriers. Hydrophilic, hydrophobic, and amphiphilic drugs are covered, and a brief overview of the amphipathic features of liposomes, phospholipids, and lipid nanocarriers is provided. Metallic nanoparticles' benefits and attendant risks are highlighted to emphasize their efficiency in treating hyperglycemia. Researchers interested in the potential of nanoparticles loaded with plant extracts as antidiabetic therapeutics may find the current helpful review.http://www.sciencedirect.com/science/article/pii/S240584402400238XDiabetes mellitusBiological macromoleculesLipid-based nanoformulationsMetal based-nanoformulationsPolymeric nanoformulations |
| spellingShingle | Naiyer Shahzad Abdullah R. Alzahrani Ibrahim Abdel Aziz Ibrahim Imran Shahid Ibrahim M. Alanazi Alaa Hisham Falemban Mohammad Tarique Imam Nehal Mohsin Mohd Fahami Nur Azlina Palanisamy Arulselvan Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review Heliyon Diabetes mellitus Biological macromolecules Lipid-based nanoformulations Metal based-nanoformulations Polymeric nanoformulations |
| title | Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review |
| title_full | Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review |
| title_fullStr | Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review |
| title_full_unstemmed | Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review |
| title_short | Therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives: A systematic review |
| title_sort | therapeutic strategy of biological macromolecules based natural bioactive compounds of diabetes mellitus and future perspectives a systematic review |
| topic | Diabetes mellitus Biological macromolecules Lipid-based nanoformulations Metal based-nanoformulations Polymeric nanoformulations |
| url | http://www.sciencedirect.com/science/article/pii/S240584402400238X |
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