Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar tim...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-02-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.604529/full |
| _version_ | 1818427351837442048 |
|---|---|
| author | Maarit Oikarinen Leena Puustinen Jussi Lehtonen Leena Hakola Leena Hakola Satu Simell Jorma Toppari Jorma Toppari Jorma Ilonen Riitta Veijola Riitta Veijola Suvi M. Virtanen Suvi M. Virtanen Suvi M. Virtanen Suvi M. Virtanen Mikael Knip Mikael Knip Mikael Knip Heikki Hyöty Heikki Hyöty |
| author_facet | Maarit Oikarinen Leena Puustinen Jussi Lehtonen Leena Hakola Leena Hakola Satu Simell Jorma Toppari Jorma Toppari Jorma Ilonen Riitta Veijola Riitta Veijola Suvi M. Virtanen Suvi M. Virtanen Suvi M. Virtanen Suvi M. Virtanen Mikael Knip Mikael Knip Mikael Knip Heikki Hyöty Heikki Hyöty |
| author_sort | Maarit Oikarinen |
| collection | DOAJ |
| description | Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8–22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease. |
| first_indexed | 2024-12-14T14:44:21Z |
| format | Article |
| id | doaj.art-c0dcd20c2b594af99f09741eaca89edf |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T14:44:21Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c0dcd20c2b594af99f09741eaca89edf2022-12-21T22:57:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011110.3389/fimmu.2020.604529604529Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort StudyMaarit Oikarinen0Leena Puustinen1Jussi Lehtonen2Leena Hakola3Leena Hakola4Satu Simell5Jorma Toppari6Jorma Toppari7Jorma Ilonen8Riitta Veijola9Riitta Veijola10Suvi M. Virtanen11Suvi M. Virtanen12Suvi M. Virtanen13Suvi M. Virtanen14Mikael Knip15Mikael Knip16Mikael Knip17Heikki Hyöty18Heikki Hyöty19Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandFaculty of Medicine and Health Technology, Tampere University, Tampere, FinlandFaculty of Medicine and Health Technology, Tampere University, Tampere, FinlandUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, FinlandResearch, Development and Innovation Center, Tampere University Hospital, Tampere, FinlandDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, FinlandDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital, Turku, FinlandInstitute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, FinlandImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, FinlandPEDEGO Research Unit, Medical Research Centre, Department of Paediatrics, University of Oulu, Oulu, FinlandDepartment of Children and Adolescents, Oulu University Hospital, Oulu, FinlandUnit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, FinlandResearch, Development and Innovation Center, Tampere University Hospital, Tampere, FinlandDepartment of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland0Center for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland0Center for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland1Pediatric Research Center, Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland2Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, FinlandFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland3Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, FinlandEnterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8–22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease.https://www.frontiersin.org/articles/10.3389/fimmu.2020.604529/fullenterovirusceliac diseasetissue transglutaminase autoantibodiesFinnish Diabetes Prediction and Prevention studyenzyme immunoassay (EIA)conditional logistic regression |
| spellingShingle | Maarit Oikarinen Leena Puustinen Jussi Lehtonen Leena Hakola Leena Hakola Satu Simell Jorma Toppari Jorma Toppari Jorma Ilonen Riitta Veijola Riitta Veijola Suvi M. Virtanen Suvi M. Virtanen Suvi M. Virtanen Suvi M. Virtanen Mikael Knip Mikael Knip Mikael Knip Heikki Hyöty Heikki Hyöty Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study Frontiers in Immunology enterovirus celiac disease tissue transglutaminase autoantibodies Finnish Diabetes Prediction and Prevention study enzyme immunoassay (EIA) conditional logistic regression |
| title | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
| title_full | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
| title_fullStr | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
| title_full_unstemmed | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
| title_short | Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study |
| title_sort | enterovirus infections are associated with the development of celiac disease in a birth cohort study |
| topic | enterovirus celiac disease tissue transglutaminase autoantibodies Finnish Diabetes Prediction and Prevention study enzyme immunoassay (EIA) conditional logistic regression |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.604529/full |
| work_keys_str_mv | AT maaritoikarinen enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT leenapuustinen enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT jussilehtonen enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT leenahakola enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT leenahakola enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT satusimell enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT jormatoppari enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT jormatoppari enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT jormailonen enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT riittaveijola enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT riittaveijola enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT suvimvirtanen enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT suvimvirtanen enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT suvimvirtanen enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT suvimvirtanen enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT mikaelknip enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT mikaelknip enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT mikaelknip enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT heikkihyoty enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy AT heikkihyoty enterovirusinfectionsareassociatedwiththedevelopmentofceliacdiseaseinabirthcohortstudy |