A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism

A Novel Cryptic Clostridial Peptide That Kills Bacteria by a Cell Membrane Permeabilization Mechanism

ABSTRACT This work reports detailed characteristics of the antimicrobial peptide Intestinalin (P30), which is derived from the LysC enzyme of Clostridium intestinale strain URNW. The peptide shows a broader antibacterial spectrum than the parental enzyme, showing potent antimicrobial activity agains...

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Bibliographic Details
Main Authors: Monika Szadkowska, Michal Olewniczak, Anna Kloska, Elzbieta Jankowska, Malgorzata Kapusta, Bartosz Rybak, Dariusz Wyrzykowski, Wioletta Zmudzinska, Artur Gieldon, Aleksandra Kocot, Anna-Karina Kaczorowska, Lukasz Nierzwicki, Joanna Makowska, Tadeusz Kaczorowski, Magdalena Plotka
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
antibacterial peptides
endolysins
membrane potential
molecular dynamics
toroidal pore model
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01657-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01657-22

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