MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER<sup>+</sup> Breast Cancer

MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER<sup>+</sup> Breast Cancer

MAGI1 acts as a tumor suppressor in estrogen receptor-positive (ER<sup>+</sup>) breast cancer (BC), and its loss correlates with a more aggressive phenotype. To identify the pathways and events affected by MAGI1 loss, we deleted the MAGI1 gene in the ER<sup>+</sup> MCF7 BC ce...

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Bibliographic Details
Main Authors: Janine Wörthmüller, Simona Disler, Sylvain Pradervand, François Richard, Lisa Haerri, Gustavo A. Ruiz Buendía, Nadine Fournier, Christine Desmedt, Curzio Rüegg
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
breast cancer
MAGI1
senescence
DNA damage
DNA repair
PI3K/AKT signaling
Online Access:https://www.mdpi.com/2073-4409/12/15/1929

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