MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER<sup>+</sup> Breast Cancer

MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER<sup>+</sup> Breast Cancer

MAGI1 acts as a tumor suppressor in estrogen receptor-positive (ER<sup>+</sup>) breast cancer (BC), and its loss correlates with a more aggressive phenotype. To identify the pathways and events affected by MAGI1 loss, we deleted the MAGI1 gene in the ER<sup>+</sup> MCF7 BC ce...

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Hlavní autoři: Janine Wörthmüller, Simona Disler, Sylvain Pradervand, François Richard, Lisa Haerri, Gustavo A. Ruiz Buendía, Nadine Fournier, Christine Desmedt, Curzio Rüegg
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2023-07-01
Edice:Cells
Témata:
breast cancer
MAGI1
senescence
DNA damage
DNA repair
PI3K/AKT signaling
On-line přístup:https://www.mdpi.com/2073-4409/12/15/1929

Internet

https://www.mdpi.com/2073-4409/12/15/1929

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