An Update on Phytochemicals and Pharmacological Activities of the Genus <i>Persicaria</i> and <i>Polygonum</i>
The discovery of new pharmaceutical identities, particularly anti-infective agents, represents an urgent need due to the increase in immunocompromised patients and the ineffectiveness/toxicity of the drugs currently used. The scientific community has recognized in the last decades the importance of...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/19/5956 |
| _version_ | 1797515943107100672 |
|---|---|
| author | Gisela Seimandi Norma Álvarez María Inés Stegmayer Laura Fernández Verónica Ruiz María Alejandra Favaro Marcos Derita |
| author_facet | Gisela Seimandi Norma Álvarez María Inés Stegmayer Laura Fernández Verónica Ruiz María Alejandra Favaro Marcos Derita |
| author_sort | Gisela Seimandi |
| collection | DOAJ |
| description | The discovery of new pharmaceutical identities, particularly anti-infective agents, represents an urgent need due to the increase in immunocompromised patients and the ineffectiveness/toxicity of the drugs currently used. The scientific community has recognized in the last decades the importance of the plant kingdom as a huge source of novel molecules which could act against different type of infections or illness. However, the great diversity of plant species makes it difficult to select them with probabilities of success, adding to the fact that existing information is difficult to find, it is atomized or disordered. <i>Persicaria</i> and <i>Polygonum</i> constitute two of the main representatives of the Polygonaceae family, which have been extensively used in traditional medicine worldwide. Important and structurally diverse bioactive compounds have been isolated from these genera of wild plants; among them, sesquiterpenes and flavonoids should be remarked. In this article, we firstly mention all the species reported with pharmacological use and their geographical distribution. Moreover, a number of tables which summarize an update detailing the type of natural product (extract or isolated compound), applied doses, displayed bioassays and the results obtained for the main bioactivities of these genera cited in the literature during the past 40 years. Antimicrobial, antioxidant, analgesic and anti-inflammatory, antinociceptive, anticancer, antiviral, antiparasitic, anti-diabetic, antipyretic, hepatoprotective, diuretic, gastroprotective and neuropharmacological activities were explored and reviewed in this work, concluding that both genera could be the source for upcoming molecules to treat different human diseases. |
| first_indexed | 2024-03-10T06:54:23Z |
| format | Article |
| id | doaj.art-c0ddbdf37acb41dea6b6f3c2502d26fd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T06:54:23Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c0ddbdf37acb41dea6b6f3c2502d26fd2023-11-22T16:35:10ZengMDPI AGMolecules1420-30492021-10-012619595610.3390/molecules26195956An Update on Phytochemicals and Pharmacological Activities of the Genus <i>Persicaria</i> and <i>Polygonum</i>Gisela Seimandi0Norma Álvarez1María Inés Stegmayer2Laura Fernández3Verónica Ruiz4María Alejandra Favaro5Marcos Derita6ICiAgro Litoral, CONICET, Facultad de Ciencias Agrarias, Universidad Nacional del Litoral, Kreder 2805, Esperanza 3080HOF, ArgentinaICiAgro Litoral, CONICET, Facultad de Ciencias Agrarias, Universidad Nacional del Litoral, Kreder 2805, Esperanza 3080HOF, ArgentinaICiAgro Litoral, CONICET, Facultad de Ciencias Agrarias, Universidad Nacional del Litoral, Kreder 2805, Esperanza 3080HOF, ArgentinaICiAgro Litoral, CONICET, Facultad de Ciencias Agrarias, Universidad Nacional del Litoral, Kreder 2805, Esperanza 3080HOF, ArgentinaICiAgro Litoral, CONICET, Facultad de Ciencias Agrarias, Universidad Nacional del Litoral, Kreder 2805, Esperanza 3080HOF, ArgentinaICiAgro Litoral, CONICET, Facultad de Ciencias Agrarias, Universidad Nacional del Litoral, Kreder 2805, Esperanza 3080HOF, ArgentinaICiAgro Litoral, CONICET, Facultad de Ciencias Agrarias, Universidad Nacional del Litoral, Kreder 2805, Esperanza 3080HOF, ArgentinaThe discovery of new pharmaceutical identities, particularly anti-infective agents, represents an urgent need due to the increase in immunocompromised patients and the ineffectiveness/toxicity of the drugs currently used. The scientific community has recognized in the last decades the importance of the plant kingdom as a huge source of novel molecules which could act against different type of infections or illness. However, the great diversity of plant species makes it difficult to select them with probabilities of success, adding to the fact that existing information is difficult to find, it is atomized or disordered. <i>Persicaria</i> and <i>Polygonum</i> constitute two of the main representatives of the Polygonaceae family, which have been extensively used in traditional medicine worldwide. Important and structurally diverse bioactive compounds have been isolated from these genera of wild plants; among them, sesquiterpenes and flavonoids should be remarked. In this article, we firstly mention all the species reported with pharmacological use and their geographical distribution. Moreover, a number of tables which summarize an update detailing the type of natural product (extract or isolated compound), applied doses, displayed bioassays and the results obtained for the main bioactivities of these genera cited in the literature during the past 40 years. Antimicrobial, antioxidant, analgesic and anti-inflammatory, antinociceptive, anticancer, antiviral, antiparasitic, anti-diabetic, antipyretic, hepatoprotective, diuretic, gastroprotective and neuropharmacological activities were explored and reviewed in this work, concluding that both genera could be the source for upcoming molecules to treat different human diseases.https://www.mdpi.com/1420-3049/26/19/5956natural products<i>Persicaria</i><i>Polygonum</i>infectious diseasesbioactive compoundspharmacological activities |
| spellingShingle | Gisela Seimandi Norma Álvarez María Inés Stegmayer Laura Fernández Verónica Ruiz María Alejandra Favaro Marcos Derita An Update on Phytochemicals and Pharmacological Activities of the Genus <i>Persicaria</i> and <i>Polygonum</i> Molecules natural products <i>Persicaria</i> <i>Polygonum</i> infectious diseases bioactive compounds pharmacological activities |
| title | An Update on Phytochemicals and Pharmacological Activities of the Genus <i>Persicaria</i> and <i>Polygonum</i> |
| title_full | An Update on Phytochemicals and Pharmacological Activities of the Genus <i>Persicaria</i> and <i>Polygonum</i> |
| title_fullStr | An Update on Phytochemicals and Pharmacological Activities of the Genus <i>Persicaria</i> and <i>Polygonum</i> |
| title_full_unstemmed | An Update on Phytochemicals and Pharmacological Activities of the Genus <i>Persicaria</i> and <i>Polygonum</i> |
| title_short | An Update on Phytochemicals and Pharmacological Activities of the Genus <i>Persicaria</i> and <i>Polygonum</i> |
| title_sort | update on phytochemicals and pharmacological activities of the genus i persicaria i and i polygonum i |
| topic | natural products <i>Persicaria</i> <i>Polygonum</i> infectious diseases bioactive compounds pharmacological activities |
| url | https://www.mdpi.com/1420-3049/26/19/5956 |
| work_keys_str_mv | AT giselaseimandi anupdateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT normaalvarez anupdateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT mariainesstegmayer anupdateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT laurafernandez anupdateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT veronicaruiz anupdateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT mariaalejandrafavaro anupdateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT marcosderita anupdateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT giselaseimandi updateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT normaalvarez updateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT mariainesstegmayer updateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT laurafernandez updateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT veronicaruiz updateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT mariaalejandrafavaro updateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi AT marcosderita updateonphytochemicalsandpharmacologicalactivitiesofthegenusipersicariaiandipolygonumi |