Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is the 10th most frequent human malignancy and is thus a global burden. Despite some progress in diagnosis and therapy, patients’ overall survival rate, between 40 and 55%, has stagnated over the last four decades. Since the tumor node metastasis (TNM) system is n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6083 |
| _version_ | 1797555978225319936 |
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| author | Alexander W. Eckert Matthias Kappler Ivo Große Claudia Wickenhauser Barbara Seliger |
| author_facet | Alexander W. Eckert Matthias Kappler Ivo Große Claudia Wickenhauser Barbara Seliger |
| author_sort | Alexander W. Eckert |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is the 10th most frequent human malignancy and is thus a global burden. Despite some progress in diagnosis and therapy, patients’ overall survival rate, between 40 and 55%, has stagnated over the last four decades. Since the tumor node metastasis (TNM) system is not precise enough to predict the disease outcome, additive factors for diagnosis, prognosis, prediction and therapy resistance are urgently needed for OSCC. One promising candidate is the hypoxia inducible factor-1 (HIF-1), which functions as an early regulator of tumor aggressiveness and is a key promoter of energy adaptation. Other parameters comprise the composition of the tumor microenvironment, which determines the availability of nutrients and oxygen. In our opinion, these general processes are linked in the pathogenesis of OSCC. Based on this assumption, the review will summarize the major features of the HIF system-induced activities, its target proteins and related pathways of nutrient utilization and metabolism that are essential for the initiation, progression and therapeutic stratification of OSCC. |
| first_indexed | 2024-03-10T16:56:10Z |
| format | Article |
| id | doaj.art-c0ddc56856e742e5b082c6bc9531c580 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:56:10Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c0ddc56856e742e5b082c6bc9531c5802023-11-20T11:08:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012117608310.3390/ijms21176083Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell CarcinomaAlexander W. Eckert0Matthias Kappler1Ivo Große2Claudia Wickenhauser3Barbara Seliger4Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Universitätsklinik der Paracelsus Medizinischen Privatuniversität, Breslauer Str. 201, 90471 Nurnberg, GermanyUniversitätsklinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Martin-Luther-Universität Halle-Wittenebrg, Ernst- Grube-Straße 40, 06120 Halle, GermanyInstitut für Informatik, Martin-Luther-Universität Halle-Wittenberg, Von-Seckendorff-Platz 1, 06120 Halle (Saale), GermanyInstitut für Pathologie, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 14, 06112 Halle (Saale), GermanyInstitut für Medizinische Immunologie, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 14, 06112 Halle (Saale), GermanyOral squamous cell carcinoma (OSCC) is the 10th most frequent human malignancy and is thus a global burden. Despite some progress in diagnosis and therapy, patients’ overall survival rate, between 40 and 55%, has stagnated over the last four decades. Since the tumor node metastasis (TNM) system is not precise enough to predict the disease outcome, additive factors for diagnosis, prognosis, prediction and therapy resistance are urgently needed for OSCC. One promising candidate is the hypoxia inducible factor-1 (HIF-1), which functions as an early regulator of tumor aggressiveness and is a key promoter of energy adaptation. Other parameters comprise the composition of the tumor microenvironment, which determines the availability of nutrients and oxygen. In our opinion, these general processes are linked in the pathogenesis of OSCC. Based on this assumption, the review will summarize the major features of the HIF system-induced activities, its target proteins and related pathways of nutrient utilization and metabolism that are essential for the initiation, progression and therapeutic stratification of OSCC.https://www.mdpi.com/1422-0067/21/17/6083oral squamous cell carcinomametabolismtumor microenvironmenthypoxiaprognosis |
| spellingShingle | Alexander W. Eckert Matthias Kappler Ivo Große Claudia Wickenhauser Barbara Seliger Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma International Journal of Molecular Sciences oral squamous cell carcinoma metabolism tumor microenvironment hypoxia prognosis |
| title | Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma |
| title_full | Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma |
| title_fullStr | Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma |
| title_short | Current Understanding of the HIF-1-Dependent Metabolism in Oral Squamous Cell Carcinoma |
| title_sort | current understanding of the hif 1 dependent metabolism in oral squamous cell carcinoma |
| topic | oral squamous cell carcinoma metabolism tumor microenvironment hypoxia prognosis |
| url | https://www.mdpi.com/1422-0067/21/17/6083 |
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