The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑analysis
AbstractBackground To quantitatively synthesize evidence from prospective observational studies regarding the mean levels of circulating adiponectin in patients with gestational diabetes mellitus (GDM) and the association between adiponectin levels and GDM risk.Methods PubMed, EMBASE and Web of Scie...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2224046 |
| _version_ | 1797353762673655808 |
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| author | Shen Gao Shaofei Su Enjie Zhang Yue Zhang Jianhui Liu Shuanghua Xie Wentao Yue Ruixia Liu Chenghong Yin |
| author_facet | Shen Gao Shaofei Su Enjie Zhang Yue Zhang Jianhui Liu Shuanghua Xie Wentao Yue Ruixia Liu Chenghong Yin |
| author_sort | Shen Gao |
| collection | DOAJ |
| description | AbstractBackground To quantitatively synthesize evidence from prospective observational studies regarding the mean levels of circulating adiponectin in patients with gestational diabetes mellitus (GDM) and the association between adiponectin levels and GDM risk.Methods PubMed, EMBASE and Web of Science were searched from their inception until November 8th, 2022, for nested case-control studies and cohort studies. Random-effect models were applied to the synthesized effect sizes. The difference in circulating adiponectin levels between the GDM and control groups was measured using the pooled standardized mean difference (SMD) and 95% confidence interval (CI). The relationship between circulating adiponectin levels and GDM risk was examined using the combined odds ratio (OR) and 95% CI. Subgroup analyses were performed according to the study continent, GDM risk in the study population, study design, gestational weeks of circulating adiponectin detection, GDM diagnostic criteria, and study quality. Sensitivity and cumulative analyses were performed to evaluate the stability of the meta-analysis. Publication bias was assessed by funnel plots and Egger’s test.Results The 28 studies included 13 cohort studies and 15 nested case-control studies, containing 12,256 pregnant women in total. The mean adiponectin level in GDM patients was significantly lower than in controls (SMD = −1.514, 95% CI = −2.400 to −0.628, p = .001, I2 = 99%). The risk of GDM was significantly decreased among pregnant women with increasing levels of circulating adiponectin (OR = 0.368, 95% CI = 0.271–0.500, p < .001, I2=83%). There were no significant differences between the subgroups.Conclusions Our findings indicate that increasing circulating adiponectin levels were inversely associated with the risk of GDM. Given the inherent heterogeneity and publication bias of the included studies, further well-designed large-scale prospective cohort or intervention studies are needed to confirm our finding. |
| first_indexed | 2024-03-08T13:35:42Z |
| format | Article |
| id | doaj.art-c0dec7d6b41c417083fc819ef39e6822 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:35:42Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-c0dec7d6b41c417083fc819ef39e68222024-01-16T19:13:21ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155110.1080/07853890.2023.2224046The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑analysisShen Gao0Shaofei Su1Enjie Zhang2Yue Zhang3Jianhui Liu4Shuanghua Xie5Wentao Yue6Ruixia Liu7Chenghong Yin8Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, ChinaDepartment of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, ChinaAbstractBackground To quantitatively synthesize evidence from prospective observational studies regarding the mean levels of circulating adiponectin in patients with gestational diabetes mellitus (GDM) and the association between adiponectin levels and GDM risk.Methods PubMed, EMBASE and Web of Science were searched from their inception until November 8th, 2022, for nested case-control studies and cohort studies. Random-effect models were applied to the synthesized effect sizes. The difference in circulating adiponectin levels between the GDM and control groups was measured using the pooled standardized mean difference (SMD) and 95% confidence interval (CI). The relationship between circulating adiponectin levels and GDM risk was examined using the combined odds ratio (OR) and 95% CI. Subgroup analyses were performed according to the study continent, GDM risk in the study population, study design, gestational weeks of circulating adiponectin detection, GDM diagnostic criteria, and study quality. Sensitivity and cumulative analyses were performed to evaluate the stability of the meta-analysis. Publication bias was assessed by funnel plots and Egger’s test.Results The 28 studies included 13 cohort studies and 15 nested case-control studies, containing 12,256 pregnant women in total. The mean adiponectin level in GDM patients was significantly lower than in controls (SMD = −1.514, 95% CI = −2.400 to −0.628, p = .001, I2 = 99%). The risk of GDM was significantly decreased among pregnant women with increasing levels of circulating adiponectin (OR = 0.368, 95% CI = 0.271–0.500, p < .001, I2=83%). There were no significant differences between the subgroups.Conclusions Our findings indicate that increasing circulating adiponectin levels were inversely associated with the risk of GDM. Given the inherent heterogeneity and publication bias of the included studies, further well-designed large-scale prospective cohort or intervention studies are needed to confirm our finding.https://www.tandfonline.com/doi/10.1080/07853890.2023.2224046Adiponectingestational diabetes mellitussystematic reviewmeta-analysis |
| spellingShingle | Shen Gao Shaofei Su Enjie Zhang Yue Zhang Jianhui Liu Shuanghua Xie Wentao Yue Ruixia Liu Chenghong Yin The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑analysis Annals of Medicine Adiponectin gestational diabetes mellitus systematic review meta-analysis |
| title | The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑analysis |
| title_full | The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑analysis |
| title_fullStr | The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑analysis |
| title_full_unstemmed | The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑analysis |
| title_short | The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑analysis |
| title_sort | effect of circulating adiponectin levels on incident gestational diabetes mellitus systematic review and meta analysis |
| topic | Adiponectin gestational diabetes mellitus systematic review meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2224046 |
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