Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease
This study aimed to compare tear film viscosity (TFV) in Sjögren and non-Sjögren dry eye diseases (DEDs). This was a cross-sectional observational study. A total of 68 DED patients were enrolled, including 32 patients with Sjögren syndrome (SS) and 36 without SS. TFV was assessed by a tear film anal...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/13/7/1484 |
| _version_ | 1827732652736643072 |
|---|---|
| author | Hung-Yin Lai Alexander Chen Po-Chiung Fang Hun-Ju Yu Ming-Tse Kuo |
| author_facet | Hung-Yin Lai Alexander Chen Po-Chiung Fang Hun-Ju Yu Ming-Tse Kuo |
| author_sort | Hung-Yin Lai |
| collection | DOAJ |
| description | This study aimed to compare tear film viscosity (TFV) in Sjögren and non-Sjögren dry eye diseases (DEDs). This was a cross-sectional observational study. A total of 68 DED patients were enrolled, including 32 patients with Sjögren syndrome (SS) and 36 without SS. TFV was assessed by a tear film analyzer and determined by the momentary moving speed (MMS; MMS (t) = α × t<sup>−β</sup>, t = time (s)) with its power-law fitting-derived parameters (α and β). Among the four indices of TFV (MMS (0.1 s), MMS (2.0 s), α, and β), the SS-DED patients had significantly lower MMS (0.1 s) (<i>p</i> = 2.01 × 10<sup>−5</sup>), α (<i>p</i> = 0.0375), and β (<i>p</i> = 0.0076). The SS-DED group also had significantly higher OSDI, lower central and nasal tear meniscus height (TMH), and higher OSS. MMS (0.1 s) was significantly correlated with nasal TMH and OSS (ρ = 0.2520, <i>p</i> = 0.0381 in nasal TMH; ρ = −0.3487, <i>p</i> = 0.0036 in OSS). Index β was not correlated with any non-TFV tests. In conclusion, MMS (0.1 s), α, and β are promising TFV indices in distinguishing SS-DED from non-SS-DED patients early. Among these TFV indices, lower MMS is the best alternative clue for detecting SS-DED. |
| first_indexed | 2024-03-11T00:55:07Z |
| format | Article |
| id | doaj.art-c0e21d3801df4ea2bdf0556895b45dbc |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T00:55:07Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-c0e21d3801df4ea2bdf0556895b45dbc2023-11-18T20:09:06ZengMDPI AGLife2075-17292023-06-01137148410.3390/life13071484Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye DiseaseHung-Yin Lai0Alexander Chen1Po-Chiung Fang2Hun-Ju Yu3Ming-Tse Kuo4Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung City 40402, TaiwanDepartment of Ophthalmology, Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung City 92842, TaiwanDepartment of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City 83301, TaiwanDepartment of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City 83301, TaiwanDepartment of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City 83301, TaiwanThis study aimed to compare tear film viscosity (TFV) in Sjögren and non-Sjögren dry eye diseases (DEDs). This was a cross-sectional observational study. A total of 68 DED patients were enrolled, including 32 patients with Sjögren syndrome (SS) and 36 without SS. TFV was assessed by a tear film analyzer and determined by the momentary moving speed (MMS; MMS (t) = α × t<sup>−β</sup>, t = time (s)) with its power-law fitting-derived parameters (α and β). Among the four indices of TFV (MMS (0.1 s), MMS (2.0 s), α, and β), the SS-DED patients had significantly lower MMS (0.1 s) (<i>p</i> = 2.01 × 10<sup>−5</sup>), α (<i>p</i> = 0.0375), and β (<i>p</i> = 0.0076). The SS-DED group also had significantly higher OSDI, lower central and nasal tear meniscus height (TMH), and higher OSS. MMS (0.1 s) was significantly correlated with nasal TMH and OSS (ρ = 0.2520, <i>p</i> = 0.0381 in nasal TMH; ρ = −0.3487, <i>p</i> = 0.0036 in OSS). Index β was not correlated with any non-TFV tests. In conclusion, MMS (0.1 s), α, and β are promising TFV indices in distinguishing SS-DED from non-SS-DED patients early. Among these TFV indices, lower MMS is the best alternative clue for detecting SS-DED.https://www.mdpi.com/2075-1729/13/7/1484tear film viscosityreflective light particlestear film homeostasisdry eye diseaseSjögren syndrome |
| spellingShingle | Hung-Yin Lai Alexander Chen Po-Chiung Fang Hun-Ju Yu Ming-Tse Kuo Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease Life tear film viscosity reflective light particles tear film homeostasis dry eye disease Sjögren syndrome |
| title | Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease |
| title_full | Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease |
| title_fullStr | Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease |
| title_full_unstemmed | Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease |
| title_short | Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease |
| title_sort | comparing tear film viscosity between sjogren and non sjogren dry eye disease |
| topic | tear film viscosity reflective light particles tear film homeostasis dry eye disease Sjögren syndrome |
| url | https://www.mdpi.com/2075-1729/13/7/1484 |
| work_keys_str_mv | AT hungyinlai comparingtearfilmviscositybetweensjogrenandnonsjogrendryeyedisease AT alexanderchen comparingtearfilmviscositybetweensjogrenandnonsjogrendryeyedisease AT pochiungfang comparingtearfilmviscositybetweensjogrenandnonsjogrendryeyedisease AT hunjuyu comparingtearfilmviscositybetweensjogrenandnonsjogrendryeyedisease AT mingtsekuo comparingtearfilmviscositybetweensjogrenandnonsjogrendryeyedisease |