Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas
Gliomas constitute a diverse and complex array of tumors within the central nervous system (CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic interventions. This literature review endeavors to conduct a thorough investigation of gliomas, with a particular emphas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/46/3/153 |
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| author | Razvan Onciul Felix-Mircea Brehar Corneliu Toader Razvan-Adrian Covache-Busuioc Luca-Andrei Glavan Bogdan-Gabriel Bratu Horia Petre Costin David-Ioan Dumitrascu Matei Serban Alexandru Vlad Ciurea |
| author_facet | Razvan Onciul Felix-Mircea Brehar Corneliu Toader Razvan-Adrian Covache-Busuioc Luca-Andrei Glavan Bogdan-Gabriel Bratu Horia Petre Costin David-Ioan Dumitrascu Matei Serban Alexandru Vlad Ciurea |
| author_sort | Razvan Onciul |
| collection | DOAJ |
| description | Gliomas constitute a diverse and complex array of tumors within the central nervous system (CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic interventions. This literature review endeavors to conduct a thorough investigation of gliomas, with a particular emphasis on glioblastoma (GBM), beginning with their classification and epidemiological characteristics, evaluating their relative importance within the CNS tumor spectrum. We examine the immunological context of gliomas, unveiling the intricate immune environment and its ramifications for disease progression and therapeutic strategies. Moreover, we accentuate critical developments in understanding tumor behavior, focusing on recent research breakthroughs in treatment responses and the elucidation of cellular signaling pathways. Analyzing the most novel transcriptomic studies, we investigate the variations in gene expression patterns in glioma cells, assessing the prognostic and therapeutic implications of these genetic alterations. Furthermore, the role of epigenetic modifications in the pathogenesis of gliomas is underscored, suggesting that such changes are fundamental to tumor evolution and possible therapeutic advancements. In the end, this comparative oncological analysis situates GBM within the wider context of neoplasms, delineating both distinct and shared characteristics with other types of tumors. |
| first_indexed | 2024-04-24T18:26:02Z |
| format | Article |
| id | doaj.art-c0e2b864cc724fc186a396bf65e18540 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-04-24T18:26:02Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-c0e2b864cc724fc186a396bf65e185402024-03-27T13:31:27ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-03-014632402244310.3390/cimb46030153Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of GliomasRazvan Onciul0Felix-Mircea Brehar1Corneliu Toader2Razvan-Adrian Covache-Busuioc3Luca-Andrei Glavan4Bogdan-Gabriel Bratu5Horia Petre Costin6David-Ioan Dumitrascu7Matei Serban8Alexandru Vlad Ciurea9Department of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaGliomas constitute a diverse and complex array of tumors within the central nervous system (CNS), characterized by a wide range of prognostic outcomes and responses to therapeutic interventions. This literature review endeavors to conduct a thorough investigation of gliomas, with a particular emphasis on glioblastoma (GBM), beginning with their classification and epidemiological characteristics, evaluating their relative importance within the CNS tumor spectrum. We examine the immunological context of gliomas, unveiling the intricate immune environment and its ramifications for disease progression and therapeutic strategies. Moreover, we accentuate critical developments in understanding tumor behavior, focusing on recent research breakthroughs in treatment responses and the elucidation of cellular signaling pathways. Analyzing the most novel transcriptomic studies, we investigate the variations in gene expression patterns in glioma cells, assessing the prognostic and therapeutic implications of these genetic alterations. Furthermore, the role of epigenetic modifications in the pathogenesis of gliomas is underscored, suggesting that such changes are fundamental to tumor evolution and possible therapeutic advancements. In the end, this comparative oncological analysis situates GBM within the wider context of neoplasms, delineating both distinct and shared characteristics with other types of tumors.https://www.mdpi.com/1467-3045/46/3/153gliomascentral nervous system tumorsepidemiologyimmunological milieutumor microenvironmenttranscriptomics |
| spellingShingle | Razvan Onciul Felix-Mircea Brehar Corneliu Toader Razvan-Adrian Covache-Busuioc Luca-Andrei Glavan Bogdan-Gabriel Bratu Horia Petre Costin David-Ioan Dumitrascu Matei Serban Alexandru Vlad Ciurea Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas Current Issues in Molecular Biology gliomas central nervous system tumors epidemiology immunological milieu tumor microenvironment transcriptomics |
| title | Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas |
| title_full | Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas |
| title_fullStr | Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas |
| title_full_unstemmed | Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas |
| title_short | Deciphering Glioblastoma: Fundamental and Novel Insights into the Biology and Therapeutic Strategies of Gliomas |
| title_sort | deciphering glioblastoma fundamental and novel insights into the biology and therapeutic strategies of gliomas |
| topic | gliomas central nervous system tumors epidemiology immunological milieu tumor microenvironment transcriptomics |
| url | https://www.mdpi.com/1467-3045/46/3/153 |
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