Irisin and Secondary Osteoporosis in Humans
Irisin is a peptide secreted by skeletal muscle following exercise that plays an important role in bone metabolism. Numerous experiments in vitro and in mouse models have shown that the administration of recombinant irisin promotes osteogenesis, protects osteocytes from dexamethasone-induced apoptos...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/2/690 |
| _version_ | 1797493389901430784 |
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| author | Roberta Zerlotin Angela Oranger Patrizia Pignataro Manuela Dicarlo Filippo Maselli Giorgio Mori Silvia Concetta Colucci Maria Grano Graziana Colaianni |
| author_facet | Roberta Zerlotin Angela Oranger Patrizia Pignataro Manuela Dicarlo Filippo Maselli Giorgio Mori Silvia Concetta Colucci Maria Grano Graziana Colaianni |
| author_sort | Roberta Zerlotin |
| collection | DOAJ |
| description | Irisin is a peptide secreted by skeletal muscle following exercise that plays an important role in bone metabolism. Numerous experiments in vitro and in mouse models have shown that the administration of recombinant irisin promotes osteogenesis, protects osteocytes from dexamethasone-induced apoptosis, prevents disuse-induced loss of bone and muscle mass, and accelerates fracture healing. Although some aspects still need to be elucidated, such as the dose- and frequency-dependent effects of irisin in cell cultures and mouse models, ample clinical evidence is emerging to support its physiological relevance on bone in humans. A reduction in serum irisin levels, associated with an increased risk of osteoporosis and bone fractures, was observed in postmenopausal women and in both men and women during aging, Recently, cohort studies of subjects with secondary osteoporosis showed that these patients have lower circulating levels of irisin, suggesting that this myokine could be a novel marker to monitor bone quality in this disease. Although there are still few studies, this review discusses the emerging data that are highlighting the involvement of irisin in some diseases that cause secondary osteoporosis. |
| first_indexed | 2024-03-10T01:19:21Z |
| format | Article |
| id | doaj.art-c0e41e915e0c4081aca7bf5d02305855 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:19:21Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c0e41e915e0c4081aca7bf5d023058552023-11-23T14:02:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-0123269010.3390/ijms23020690Irisin and Secondary Osteoporosis in HumansRoberta Zerlotin0Angela Oranger1Patrizia Pignataro2Manuela Dicarlo3Filippo Maselli4Giorgio Mori5Silvia Concetta Colucci6Maria Grano7Graziana Colaianni8Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, 70124 Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, 70124 Bari, ItalyDepartment of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation, University of Bari, 70124 Bari, ItalyIrisin is a peptide secreted by skeletal muscle following exercise that plays an important role in bone metabolism. Numerous experiments in vitro and in mouse models have shown that the administration of recombinant irisin promotes osteogenesis, protects osteocytes from dexamethasone-induced apoptosis, prevents disuse-induced loss of bone and muscle mass, and accelerates fracture healing. Although some aspects still need to be elucidated, such as the dose- and frequency-dependent effects of irisin in cell cultures and mouse models, ample clinical evidence is emerging to support its physiological relevance on bone in humans. A reduction in serum irisin levels, associated with an increased risk of osteoporosis and bone fractures, was observed in postmenopausal women and in both men and women during aging, Recently, cohort studies of subjects with secondary osteoporosis showed that these patients have lower circulating levels of irisin, suggesting that this myokine could be a novel marker to monitor bone quality in this disease. Although there are still few studies, this review discusses the emerging data that are highlighting the involvement of irisin in some diseases that cause secondary osteoporosis.https://www.mdpi.com/1422-0067/23/2/690irisinosteoporosishyperparathyroidismPrader–Willi syndromegrowth hormoneCushing’s disease |
| spellingShingle | Roberta Zerlotin Angela Oranger Patrizia Pignataro Manuela Dicarlo Filippo Maselli Giorgio Mori Silvia Concetta Colucci Maria Grano Graziana Colaianni Irisin and Secondary Osteoporosis in Humans International Journal of Molecular Sciences irisin osteoporosis hyperparathyroidism Prader–Willi syndrome growth hormone Cushing’s disease |
| title | Irisin and Secondary Osteoporosis in Humans |
| title_full | Irisin and Secondary Osteoporosis in Humans |
| title_fullStr | Irisin and Secondary Osteoporosis in Humans |
| title_full_unstemmed | Irisin and Secondary Osteoporosis in Humans |
| title_short | Irisin and Secondary Osteoporosis in Humans |
| title_sort | irisin and secondary osteoporosis in humans |
| topic | irisin osteoporosis hyperparathyroidism Prader–Willi syndrome growth hormone Cushing’s disease |
| url | https://www.mdpi.com/1422-0067/23/2/690 |
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