Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity
Multiple diagnostic tools are used to evaluate psoriasis and atopic dermatitis (AD) severity, but most of them are based on subjective components. Transepidermal water loss (TEWL) and temperature are skin barrier function parameters that can be objectively measured and could help clinicians to evalu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/2/359 |
| _version_ | 1797409834346217472 |
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| author | Trinidad Montero-Vilchez María-Victoria Segura-Fernández-Nogueras Isabel Pérez-Rodríguez Miguel Soler-Gongora Antonio Martinez-Lopez Ana Fernández-González Alejandro Molina-Leyva Salvador Arias-Santiago |
| author_facet | Trinidad Montero-Vilchez María-Victoria Segura-Fernández-Nogueras Isabel Pérez-Rodríguez Miguel Soler-Gongora Antonio Martinez-Lopez Ana Fernández-González Alejandro Molina-Leyva Salvador Arias-Santiago |
| author_sort | Trinidad Montero-Vilchez |
| collection | DOAJ |
| description | Multiple diagnostic tools are used to evaluate psoriasis and atopic dermatitis (AD) severity, but most of them are based on subjective components. Transepidermal water loss (TEWL) and temperature are skin barrier function parameters that can be objectively measured and could help clinicians to evaluate disease severity accurately. Thus, the aims of this study are: (1) to compare skin barrier function between healthy skin, psoriatic skin and AD skin; and (2) to assess if skin barrier function parameters could predict disease severity. A cross-sectional study was designed, and epidermal barrier function parameters were measured. The study included 314 participants: 157 healthy individuals, 92 psoriatic patients, and 65 atopic dermatitis patients. TEWL was significantly higher, while stratum corneum hydration (SCH) (8.71 vs. 38.43 vs. 44.39 Arbitrary Units (AU)) was lower at psoriatic plaques than at uninvolved psoriatic skin and healthy controls. Patients with both TEWL > 13.85 g·m<sup>−2</sup>h<sup>−1</sup> and temperature > 30.85 °C presented a moderate/severe psoriasis (psoriasis area severity index (PASI) ≥ 7), with a specificity of 76.3%. TEWL (28.68 vs. 13.15 vs. 11.60 g·m<sup>−2</sup> h<sup>−1</sup>) and temperature were significantly higher, while SCH (25.20 vs. 40.95 vs. 50.73 AU) was lower at AD eczematous lesions than uninvolved AD skin and healthy controls. Patients with a temperature > 31.75 °C presented a moderate/severe AD (SCORing Atopic Dermatitis (SCORAD) ≥ 37) with a sensitivity of 81.8%. In conclusion, temperature and TEWL values may help clinicians to determine disease severity and select patients who need intensive treatment. |
| first_indexed | 2024-03-09T04:21:16Z |
| format | Article |
| id | doaj.art-c0e453ec68a2417cb4b2609a9af0f369 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:21:16Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c0e453ec68a2417cb4b2609a9af0f3692023-12-03T13:47:54ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110235910.3390/jcm10020359Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease SeverityTrinidad Montero-Vilchez0María-Victoria Segura-Fernández-Nogueras1Isabel Pérez-Rodríguez2Miguel Soler-Gongora3Antonio Martinez-Lopez4Ana Fernández-González5Alejandro Molina-Leyva6Salvador Arias-Santiago7Dermatology Department, Hospital Universitario Virgen de las Nieves, Avenida de Madrid, 15, 18012 Granada, SpainDermatology Department, Faculty of Medicine, University of Granada,18001 Granada, SpainDermatology Department, Faculty of Medicine, University of Granada,18001 Granada, SpainDermatology Department, Faculty of Medicine, University of Granada,18001 Granada, SpainDermatology Department, Hospital Universitario Virgen de las Nieves, Avenida de Madrid, 15, 18012 Granada, SpainInstituto de Investigación Biosanitaria GRANADA, 18012 Granada, SpainDermatology Department, Hospital Universitario Virgen de las Nieves, Avenida de Madrid, 15, 18012 Granada, SpainDermatology Department, Hospital Universitario Virgen de las Nieves, Avenida de Madrid, 15, 18012 Granada, SpainMultiple diagnostic tools are used to evaluate psoriasis and atopic dermatitis (AD) severity, but most of them are based on subjective components. Transepidermal water loss (TEWL) and temperature are skin barrier function parameters that can be objectively measured and could help clinicians to evaluate disease severity accurately. Thus, the aims of this study are: (1) to compare skin barrier function between healthy skin, psoriatic skin and AD skin; and (2) to assess if skin barrier function parameters could predict disease severity. A cross-sectional study was designed, and epidermal barrier function parameters were measured. The study included 314 participants: 157 healthy individuals, 92 psoriatic patients, and 65 atopic dermatitis patients. TEWL was significantly higher, while stratum corneum hydration (SCH) (8.71 vs. 38.43 vs. 44.39 Arbitrary Units (AU)) was lower at psoriatic plaques than at uninvolved psoriatic skin and healthy controls. Patients with both TEWL > 13.85 g·m<sup>−2</sup>h<sup>−1</sup> and temperature > 30.85 °C presented a moderate/severe psoriasis (psoriasis area severity index (PASI) ≥ 7), with a specificity of 76.3%. TEWL (28.68 vs. 13.15 vs. 11.60 g·m<sup>−2</sup> h<sup>−1</sup>) and temperature were significantly higher, while SCH (25.20 vs. 40.95 vs. 50.73 AU) was lower at AD eczematous lesions than uninvolved AD skin and healthy controls. Patients with a temperature > 31.75 °C presented a moderate/severe AD (SCORing Atopic Dermatitis (SCORAD) ≥ 37) with a sensitivity of 81.8%. In conclusion, temperature and TEWL values may help clinicians to determine disease severity and select patients who need intensive treatment.https://www.mdpi.com/2077-0383/10/2/359atopic dermatitishomeostasispsoriasisskin barriertransepidermal water loss |
| spellingShingle | Trinidad Montero-Vilchez María-Victoria Segura-Fernández-Nogueras Isabel Pérez-Rodríguez Miguel Soler-Gongora Antonio Martinez-Lopez Ana Fernández-González Alejandro Molina-Leyva Salvador Arias-Santiago Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity Journal of Clinical Medicine atopic dermatitis homeostasis psoriasis skin barrier transepidermal water loss |
| title | Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity |
| title_full | Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity |
| title_fullStr | Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity |
| title_full_unstemmed | Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity |
| title_short | Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity |
| title_sort | skin barrier function in psoriasis and atopic dermatitis transepidermal water loss and temperature as useful tools to assess disease severity |
| topic | atopic dermatitis homeostasis psoriasis skin barrier transepidermal water loss |
| url | https://www.mdpi.com/2077-0383/10/2/359 |
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