Risk factors for early mortality of lung cancer patients in France: A nationwide analysis
Abstract Background Despite therapeutic advances, lung cancer remains the first cause of death from cancer. The main objective of this study was to identify risk factors associated with death within 3‐months of the first hospitalization for lung cancer in France. Methods This analysis included patie...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.4821 |
| _version_ | 1811196472207605760 |
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| author | Hélène Goussault Sébastien Gendarme Jean‐Baptiste Assié Camille Jung Salomé Epaud Christelle Algans Noémie Salaun‐Penquer Mathilde Rousseau Andrea Lazatti Christos Chouaïd |
| author_facet | Hélène Goussault Sébastien Gendarme Jean‐Baptiste Assié Camille Jung Salomé Epaud Christelle Algans Noémie Salaun‐Penquer Mathilde Rousseau Andrea Lazatti Christos Chouaïd |
| author_sort | Hélène Goussault |
| collection | DOAJ |
| description | Abstract Background Despite therapeutic advances, lung cancer remains the first cause of death from cancer. The main objective of this study was to identify risk factors associated with death within 3‐months of the first hospitalization for lung cancer in France. Methods This analysis included patients with a first hospitalization for lung cancer (between January 1, 2016 and December 31, 2018) according to diagnosis‐related groups entered into the French national medical‐administrative database. Clinical and socioeconomic parameters and characteristics of that first hospitalization were analyzed. A model predictive of early mortality was developed based on those variables. Results The 144,087 included patients were 67% men; median age of 68 [interquartile range 60–76] years; 47% had metastatic disease at diagnosis; and 34% and 23%, respectively, had received systemic treatment or undergone curative surgery. The 3‐month mortality was 19%, and significantly higher for those ≥70 versus <70 years old (OR 1.33, 1.22–1.45), men versus. women (OR 1.50, 1.44–1.55), those with metastatic disease at diagnosis (OR, 3.30, 3.18–3.43), first hospitalization via the emergency room (OR 1.65 1.59–1.71) and first hospitalization lasting >30 days (OR, 1.58 1.49–1.68). In contrast, no socioeconomic characteristic was associated with early mortality. Conclusion Almost 1 in 5 patients diagnosed with lung cancer in France died within 3 months post‐diagnosis. Improving survival requires diagnosis at an earlier stage and better organization of diagnosis and specific care pathways. |
| first_indexed | 2024-04-12T00:59:22Z |
| format | Article |
| id | doaj.art-c0e458041f3949f38b24890f428007eb |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-12T00:59:22Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-c0e458041f3949f38b24890f428007eb2022-12-22T03:54:32ZengWileyCancer Medicine2045-76342022-12-0111245025503410.1002/cam4.4821Risk factors for early mortality of lung cancer patients in France: A nationwide analysisHélène Goussault0Sébastien Gendarme1Jean‐Baptiste Assié2Camille Jung3Salomé Epaud4Christelle Algans5Noémie Salaun‐Penquer6Mathilde Rousseau7Andrea Lazatti8Christos Chouaïd9Département de Pneumologie CHI de Créteil Créteil FranceDépartement de Pneumologie CHI de Créteil Créteil FranceDépartement de Pneumologie CHI de Créteil Créteil FranceCentre de Recherche Clinique CHI de Créteil Créteil FranceKaduceo Toulouse FranceKaduceo Toulouse FranceKaduceo Toulouse FranceDepartment d'Information médicale CHI de Créteil Créteil FranceDépartement de Chirurgie Digestive CHI de Créteil Créteil FranceDépartement de Pneumologie CHI de Créteil Créteil FranceAbstract Background Despite therapeutic advances, lung cancer remains the first cause of death from cancer. The main objective of this study was to identify risk factors associated with death within 3‐months of the first hospitalization for lung cancer in France. Methods This analysis included patients with a first hospitalization for lung cancer (between January 1, 2016 and December 31, 2018) according to diagnosis‐related groups entered into the French national medical‐administrative database. Clinical and socioeconomic parameters and characteristics of that first hospitalization were analyzed. A model predictive of early mortality was developed based on those variables. Results The 144,087 included patients were 67% men; median age of 68 [interquartile range 60–76] years; 47% had metastatic disease at diagnosis; and 34% and 23%, respectively, had received systemic treatment or undergone curative surgery. The 3‐month mortality was 19%, and significantly higher for those ≥70 versus <70 years old (OR 1.33, 1.22–1.45), men versus. women (OR 1.50, 1.44–1.55), those with metastatic disease at diagnosis (OR, 3.30, 3.18–3.43), first hospitalization via the emergency room (OR 1.65 1.59–1.71) and first hospitalization lasting >30 days (OR, 1.58 1.49–1.68). In contrast, no socioeconomic characteristic was associated with early mortality. Conclusion Almost 1 in 5 patients diagnosed with lung cancer in France died within 3 months post‐diagnosis. Improving survival requires diagnosis at an earlier stage and better organization of diagnosis and specific care pathways.https://doi.org/10.1002/cam4.4821early mortalityepidemiologylung cancermortalityprognosis |
| spellingShingle | Hélène Goussault Sébastien Gendarme Jean‐Baptiste Assié Camille Jung Salomé Epaud Christelle Algans Noémie Salaun‐Penquer Mathilde Rousseau Andrea Lazatti Christos Chouaïd Risk factors for early mortality of lung cancer patients in France: A nationwide analysis Cancer Medicine early mortality epidemiology lung cancer mortality prognosis |
| title | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
| title_full | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
| title_fullStr | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
| title_full_unstemmed | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
| title_short | Risk factors for early mortality of lung cancer patients in France: A nationwide analysis |
| title_sort | risk factors for early mortality of lung cancer patients in france a nationwide analysis |
| topic | early mortality epidemiology lung cancer mortality prognosis |
| url | https://doi.org/10.1002/cam4.4821 |
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