Metformin and ICG-001 Act Synergistically to Abrogate Cancer Stem Cells-Mediated Chemoresistance in Colorectal Cancer by Promoting Apoptosis and Autophagy

Metformin and ICG-001 Act Synergistically to Abrogate Cancer Stem Cells-Mediated Chemoresistance in Colorectal Cancer by Promoting Apoptosis and Autophagy

Colorectal cancer (CRC) remains the third most frequently diagnosed cancer in the United States. The current treatment regimens for CRC include surgery followed by 5FU-based chemotherapy. Cancer stem-like cells (CSCs) have been implicated in 5FU-mediated chemoresistance, which leads to poor prognosi...

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Bibliographic Details
Main Authors: Souvick Roy, Yinghui Zhao, Yate-Ching Yuan, Ajay Goel
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
colorectal cancer
5FU-resistance
cancer stem-like cells
metformin
ICG-001
Online Access:https://www.mdpi.com/2072-6694/14/5/1281

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