Post-operative recurrence of focal segmental glomerulosclerosis according to pre-transplant treatment after kidney transplantation
Abstract Background Recurrent focal segmental glomerulosclerosis (FSGS) after kidney transplantation (KT) is a serious complication and a significant risk factor for graft failure. However, there is no clear evidence of the effectiveness of pre-transplant treatment using plasmapheresis (PP) or ritux...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-023-03098-1 |
| _version_ | 1797865354669588480 |
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| author | Hye Eun Kwon Young Hoon Kim Sang Ah Lee Jae Jun Lee Youngmin Ko Sung Shin Joo Hee Jung Frances S. Sung Chung Hee Baek Hyosang Kim Su-Kil Park Hyunwook Kwon |
| author_facet | Hye Eun Kwon Young Hoon Kim Sang Ah Lee Jae Jun Lee Youngmin Ko Sung Shin Joo Hee Jung Frances S. Sung Chung Hee Baek Hyosang Kim Su-Kil Park Hyunwook Kwon |
| author_sort | Hye Eun Kwon |
| collection | DOAJ |
| description | Abstract Background Recurrent focal segmental glomerulosclerosis (FSGS) after kidney transplantation (KT) is a serious complication and a significant risk factor for graft failure. However, there is no clear evidence of the effectiveness of pre-transplant treatment using plasmapheresis (PP) or rituximab in preventing post-operative FSGS recurrence after KT. Methods This single-center retrospective study included 99 adult patients with biopsy-proven primary FSGS who underwent KT between 2007 and 2018. The patients were divided into the pre-treatment group (N = 53, 53.5%) and no pre-treatment group (N = 46, 46.5%). In the pre-transplant group, prophylactic PP was administered before KT in patients undergoing living donor transplantation and the day after KT in those undergoing deceased donor transplantation. Results The rate of immediate post-operative recurrence was significantly higher in the no pre-treatment group (16 [34.8%]) than in the pre-treatment group (5 [9.4%]; P = 0.002). There were three cases of graft failure due to recurrent FSGS, all of which were in the no pre-treatment group. After adjusting for possible confounding factors, age (per 10-year increase; OR = 0.61, CI, 0.42–0.90; P = 0.012) and pre-transplant treatment (vs. no pre-transplant treatment; OR = 0.17, CI, 0.05–0.54; P = 0.003) were identified as significant factors associated with FSGS recurrence. The rate of death-censored graft survival was significantly superior in the pretransplant treatment group (P = 0.042). Conclusion Pre-transplant treatment with PP was associated with beneficial effects on preventing FSGS recurrence after KT. |
| first_indexed | 2024-04-09T23:06:41Z |
| format | Article |
| id | doaj.art-c0e6c8fb7f9e4395a70e122102fb2659 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-09T23:06:41Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-c0e6c8fb7f9e4395a70e122102fb26592023-03-22T10:40:14ZengBMCBMC Nephrology1471-23692023-03-012411810.1186/s12882-023-03098-1Post-operative recurrence of focal segmental glomerulosclerosis according to pre-transplant treatment after kidney transplantationHye Eun Kwon0Young Hoon Kim1Sang Ah Lee2Jae Jun Lee3Youngmin Ko4Sung Shin5Joo Hee Jung6Frances S. Sung7Chung Hee Baek8Hyosang Kim9Su-Kil Park10Hyunwook Kwon11Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of MedicineDivision of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of MedicineDivision of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of MedicineDivision of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of MedicineDivision of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of MedicineDivision of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of MedicineDivision of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of MedicineDivision of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of MedicineDivision of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of MedicineDivision of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of MedicineDivision of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of MedicineDivision of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of MedicineAbstract Background Recurrent focal segmental glomerulosclerosis (FSGS) after kidney transplantation (KT) is a serious complication and a significant risk factor for graft failure. However, there is no clear evidence of the effectiveness of pre-transplant treatment using plasmapheresis (PP) or rituximab in preventing post-operative FSGS recurrence after KT. Methods This single-center retrospective study included 99 adult patients with biopsy-proven primary FSGS who underwent KT between 2007 and 2018. The patients were divided into the pre-treatment group (N = 53, 53.5%) and no pre-treatment group (N = 46, 46.5%). In the pre-transplant group, prophylactic PP was administered before KT in patients undergoing living donor transplantation and the day after KT in those undergoing deceased donor transplantation. Results The rate of immediate post-operative recurrence was significantly higher in the no pre-treatment group (16 [34.8%]) than in the pre-treatment group (5 [9.4%]; P = 0.002). There were three cases of graft failure due to recurrent FSGS, all of which were in the no pre-treatment group. After adjusting for possible confounding factors, age (per 10-year increase; OR = 0.61, CI, 0.42–0.90; P = 0.012) and pre-transplant treatment (vs. no pre-transplant treatment; OR = 0.17, CI, 0.05–0.54; P = 0.003) were identified as significant factors associated with FSGS recurrence. The rate of death-censored graft survival was significantly superior in the pretransplant treatment group (P = 0.042). Conclusion Pre-transplant treatment with PP was associated with beneficial effects on preventing FSGS recurrence after KT.https://doi.org/10.1186/s12882-023-03098-1Kidney transplantationFocal segmental glomerulosclerosisPlasmapheresis |
| spellingShingle | Hye Eun Kwon Young Hoon Kim Sang Ah Lee Jae Jun Lee Youngmin Ko Sung Shin Joo Hee Jung Frances S. Sung Chung Hee Baek Hyosang Kim Su-Kil Park Hyunwook Kwon Post-operative recurrence of focal segmental glomerulosclerosis according to pre-transplant treatment after kidney transplantation BMC Nephrology Kidney transplantation Focal segmental glomerulosclerosis Plasmapheresis |
| title | Post-operative recurrence of focal segmental glomerulosclerosis according to pre-transplant treatment after kidney transplantation |
| title_full | Post-operative recurrence of focal segmental glomerulosclerosis according to pre-transplant treatment after kidney transplantation |
| title_fullStr | Post-operative recurrence of focal segmental glomerulosclerosis according to pre-transplant treatment after kidney transplantation |
| title_full_unstemmed | Post-operative recurrence of focal segmental glomerulosclerosis according to pre-transplant treatment after kidney transplantation |
| title_short | Post-operative recurrence of focal segmental glomerulosclerosis according to pre-transplant treatment after kidney transplantation |
| title_sort | post operative recurrence of focal segmental glomerulosclerosis according to pre transplant treatment after kidney transplantation |
| topic | Kidney transplantation Focal segmental glomerulosclerosis Plasmapheresis |
| url | https://doi.org/10.1186/s12882-023-03098-1 |
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