Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing
The major goal of animal breeding is the genetic enhancement of economic traits. The CRISPR/Cas system, which includes nuclease-mediated and base editor mediated genome editing tools, provides an unprecedented approach to modify the mammalian genome. Thus, farm animal genetic engineering and genetic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7331 |
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| author | Zhiguo Liu Tianwen Wu Guangming Xiang Hui Wang Bingyuan Wang Zheng Feng Yulian Mu Kui Li |
| author_facet | Zhiguo Liu Tianwen Wu Guangming Xiang Hui Wang Bingyuan Wang Zheng Feng Yulian Mu Kui Li |
| author_sort | Zhiguo Liu |
| collection | DOAJ |
| description | The major goal of animal breeding is the genetic enhancement of economic traits. The CRISPR/Cas system, which includes nuclease-mediated and base editor mediated genome editing tools, provides an unprecedented approach to modify the mammalian genome. Thus, farm animal genetic engineering and genetic manipulation have been fundamentally revolutionized. Agricultural animals with traits of interest can be obtained in just one generation (and without long time selection). Here, we reviewed the advancements of the CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated proteins) genome editing tools and their applications in animal breeding, especially in improving disease resistance, production performance, and animal welfare. Additionally, we covered the regulations on genome-edited animals (GEAs) and ways to accelerate their use. Recommendations for how to produce GEAs were also discussed. Despite the current challenges, we believe that genome editing breeding and GEAs will be available in the near future. |
| first_indexed | 2024-03-09T21:48:20Z |
| format | Article |
| id | doaj.art-c0e8dfbded9d4972bab3ce6c3a796a6a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:48:20Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c0e8dfbded9d4972bab3ce6c3a796a6a2023-11-23T20:11:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313733110.3390/ijms23137331Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome EditingZhiguo Liu0Tianwen Wu1Guangming Xiang2Hui Wang3Bingyuan Wang4Zheng Feng5Yulian Mu6Kui Li7State Key Laboratory of Animal Nutrition, Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaGuangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Key Laboratory of Animal Molecular Design and Precise Breeding of Guangdong Higher Education Institutes, School of Life Science and Engineering, Foshan University, Foshan 528231, ChinaState Key Laboratory of Animal Nutrition, Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory of Animal Nutrition, Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaThe major goal of animal breeding is the genetic enhancement of economic traits. The CRISPR/Cas system, which includes nuclease-mediated and base editor mediated genome editing tools, provides an unprecedented approach to modify the mammalian genome. Thus, farm animal genetic engineering and genetic manipulation have been fundamentally revolutionized. Agricultural animals with traits of interest can be obtained in just one generation (and without long time selection). Here, we reviewed the advancements of the CRISPR (Clustered regularly interspaced short palindromic repeats)/Cas (CRISPR associated proteins) genome editing tools and their applications in animal breeding, especially in improving disease resistance, production performance, and animal welfare. Additionally, we covered the regulations on genome-edited animals (GEAs) and ways to accelerate their use. Recommendations for how to produce GEAs were also discussed. Despite the current challenges, we believe that genome editing breeding and GEAs will be available in the near future.https://www.mdpi.com/1422-0067/23/13/7331livestock animalsgenome editingprecision breedingdisease resistanceregulatory system |
| spellingShingle | Zhiguo Liu Tianwen Wu Guangming Xiang Hui Wang Bingyuan Wang Zheng Feng Yulian Mu Kui Li Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing International Journal of Molecular Sciences livestock animals genome editing precision breeding disease resistance regulatory system |
| title | Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing |
| title_full | Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing |
| title_fullStr | Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing |
| title_full_unstemmed | Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing |
| title_short | Enhancing Animal Disease Resistance, Production Efficiency, and Welfare through Precise Genome Editing |
| title_sort | enhancing animal disease resistance production efficiency and welfare through precise genome editing |
| topic | livestock animals genome editing precision breeding disease resistance regulatory system |
| url | https://www.mdpi.com/1422-0067/23/13/7331 |
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