Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers
The deposition of highly phosphorylated and aggregated tau is a characteristic of tauopathies, including Alzheimer's disease. It has long been known that different isoforms of tau are aggregated in different cell types and brain regions in each tauopathy. Recent advances in analytical technique...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2024-02-01
|
Series: | FEBS Open Bio |
Subjects: | |
Online Access: | https://doi.org/10.1002/2211-5463.13667 |
_version_ | 1827357849990201344 |
---|---|
author | Taeko Kimura Haruaki Sato Maria Kano Lisa Tatsumi Taisuke Tomita |
author_facet | Taeko Kimura Haruaki Sato Maria Kano Lisa Tatsumi Taisuke Tomita |
author_sort | Taeko Kimura |
collection | DOAJ |
description | The deposition of highly phosphorylated and aggregated tau is a characteristic of tauopathies, including Alzheimer's disease. It has long been known that different isoforms of tau are aggregated in different cell types and brain regions in each tauopathy. Recent advances in analytical techniques revealed the details of the biochemical and structural biological differences of tau specific to each tauopathy. In this review, we explain recent advances in the analysis of post‐translational modifications of tau, particularly phosphorylation, brought about by the development of mass‐spectrometry and Phos‐tag technology. We then discuss the structure of tau filaments in each tauopathy revealed by the advent of cryo‐EM. Finally, we describe the progress in biofluid and imaging biomarkers for tauopathy. This review summarizes current efforts to elucidate the characteristics of pathological tau and the landscape of the use of tau as a biomarker to diagnose and determine the pathological stage of tauopathy. |
first_indexed | 2024-03-08T05:53:59Z |
format | Article |
id | doaj.art-c0e9e5e63afc43189335879b673e1ac0 |
institution | Directory Open Access Journal |
issn | 2211-5463 |
language | English |
last_indexed | 2024-03-08T05:53:59Z |
publishDate | 2024-02-01 |
publisher | Wiley |
record_format | Article |
series | FEBS Open Bio |
spelling | doaj.art-c0e9e5e63afc43189335879b673e1ac02024-02-05T06:39:38ZengWileyFEBS Open Bio2211-54632024-02-0114218119310.1002/2211-5463.13667Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkersTaeko Kimura0Haruaki Sato1Maria Kano2Lisa Tatsumi3Taisuke Tomita4Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences The University of Tokyo JapanLaboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences The University of Tokyo JapanLaboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences The University of Tokyo JapanLaboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences The University of Tokyo JapanLaboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences The University of Tokyo JapanThe deposition of highly phosphorylated and aggregated tau is a characteristic of tauopathies, including Alzheimer's disease. It has long been known that different isoforms of tau are aggregated in different cell types and brain regions in each tauopathy. Recent advances in analytical techniques revealed the details of the biochemical and structural biological differences of tau specific to each tauopathy. In this review, we explain recent advances in the analysis of post‐translational modifications of tau, particularly phosphorylation, brought about by the development of mass‐spectrometry and Phos‐tag technology. We then discuss the structure of tau filaments in each tauopathy revealed by the advent of cryo‐EM. Finally, we describe the progress in biofluid and imaging biomarkers for tauopathy. This review summarizes current efforts to elucidate the characteristics of pathological tau and the landscape of the use of tau as a biomarker to diagnose and determine the pathological stage of tauopathy.https://doi.org/10.1002/2211-5463.13667Alzheimer's diseaseblood biomarkercryo‐EMphosphorylationtau PETtauopathy |
spellingShingle | Taeko Kimura Haruaki Sato Maria Kano Lisa Tatsumi Taisuke Tomita Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers FEBS Open Bio Alzheimer's disease blood biomarker cryo‐EM phosphorylation tau PET tauopathy |
title | Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers |
title_full | Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers |
title_fullStr | Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers |
title_full_unstemmed | Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers |
title_short | Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers |
title_sort | novel aspects of the phosphorylation and structure of pathological tau implications for tauopathy biomarkers |
topic | Alzheimer's disease blood biomarker cryo‐EM phosphorylation tau PET tauopathy |
url | https://doi.org/10.1002/2211-5463.13667 |
work_keys_str_mv | AT taekokimura novelaspectsofthephosphorylationandstructureofpathologicaltauimplicationsfortauopathybiomarkers AT haruakisato novelaspectsofthephosphorylationandstructureofpathologicaltauimplicationsfortauopathybiomarkers AT mariakano novelaspectsofthephosphorylationandstructureofpathologicaltauimplicationsfortauopathybiomarkers AT lisatatsumi novelaspectsofthephosphorylationandstructureofpathologicaltauimplicationsfortauopathybiomarkers AT taisuketomita novelaspectsofthephosphorylationandstructureofpathologicaltauimplicationsfortauopathybiomarkers |