3445 Cannabis use and risk of H. pylori infection; analysis of inpatients and residents of the US.
OBJECTIVES/SPECIFIC AIMS: Cannabinoids suppress gastric acid secretion, ameliorate gastric inflammation, and promote gastric ulcer healing, all of which are triggered by H pylori (Hp). Our aim was to determine the relationship between cannabis use and: 1) H pylori infection (HPI) among community res...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2019-03-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S205986611900089X/type/journal_article |
| _version_ | 1811156663810392064 |
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| author | Adeyinka Charles Adejumo Terence Ndonyi Bukong |
| author_facet | Adeyinka Charles Adejumo Terence Ndonyi Bukong |
| author_sort | Adeyinka Charles Adejumo |
| collection | DOAJ |
| description | OBJECTIVES/SPECIFIC AIMS: Cannabinoids suppress gastric acid secretion, ameliorate gastric inflammation, and promote gastric ulcer healing, all of which are triggered by H pylori (Hp). Our aim was to determine the relationship between cannabis use and: 1) H pylori infection (HPI) among community residents 2) clinical peptic ulcer disease (PUD) and its complications among hospitalized patients. METHODS/STUDY POPULATION: We performed case-control studies with records from the NHANES III (n=4,556) and HCUP-NIS 2014 (n=4,555,029), and respectively identified subjects with seropositivity for H pylori and clinical PUD, and their cannabis usage status. In the NHANES III, we estimated the adjusted prevalence rate ratio (aPRR) of having HPI with cannabis use, using generalized estimating equations. In the NIS, we propensity-matched cannabis users to non-users in ratio 1:1 (68,073:68,073) and measured the aPRR of having PUD and its complications (SAS 9.4). RESULTS/ANTICIPATED RESULTS: In NHANES III, associated with decreased HPI seropositivity were cannabis ever-users (aPRR: 0.79[0.66-0.95]), greater than 10 times lifetime usage (0.65[0.5-0.84]) and recent 31-day usage (0.67[0.48-0.98]), compared to never usage. In the HCUP-NIS, cannabis users had decreased risk for total PUD (aPRR: 0.74[0.61-0.89]), duodenal PUD (0.48[0.35-0.60]) and PUD complications including hemorrhage (0.58[0.37-0.90]), perforation (0.66[0.51-0.87]), but not obstruction (1.75[0.51-5.98]). DISCUSSION/SIGNIFICANCE OF IMPACT: Cannabis usage is related to a reduced likelihood of having HPI in the community and also mitigate against having complicated presentations to the hospital. More translational studies are needed to illuminate the details of this relationship, given the high worldwide prevalence of both cannabis use and HPI. |
| first_indexed | 2024-04-10T04:55:05Z |
| format | Article |
| id | doaj.art-c0ea92516ce64b8e81753c10bdd87f07 |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-10T04:55:05Z |
| publishDate | 2019-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-c0ea92516ce64b8e81753c10bdd87f072023-03-09T12:30:29ZengCambridge University PressJournal of Clinical and Translational Science2059-86612019-03-013363710.1017/cts.2019.893445 Cannabis use and risk of H. pylori infection; analysis of inpatients and residents of the US.Adeyinka Charles Adejumo0Terence Ndonyi Bukong1North Shore Medical CenterNorth Shore Medical CenterOBJECTIVES/SPECIFIC AIMS: Cannabinoids suppress gastric acid secretion, ameliorate gastric inflammation, and promote gastric ulcer healing, all of which are triggered by H pylori (Hp). Our aim was to determine the relationship between cannabis use and: 1) H pylori infection (HPI) among community residents 2) clinical peptic ulcer disease (PUD) and its complications among hospitalized patients. METHODS/STUDY POPULATION: We performed case-control studies with records from the NHANES III (n=4,556) and HCUP-NIS 2014 (n=4,555,029), and respectively identified subjects with seropositivity for H pylori and clinical PUD, and their cannabis usage status. In the NHANES III, we estimated the adjusted prevalence rate ratio (aPRR) of having HPI with cannabis use, using generalized estimating equations. In the NIS, we propensity-matched cannabis users to non-users in ratio 1:1 (68,073:68,073) and measured the aPRR of having PUD and its complications (SAS 9.4). RESULTS/ANTICIPATED RESULTS: In NHANES III, associated with decreased HPI seropositivity were cannabis ever-users (aPRR: 0.79[0.66-0.95]), greater than 10 times lifetime usage (0.65[0.5-0.84]) and recent 31-day usage (0.67[0.48-0.98]), compared to never usage. In the HCUP-NIS, cannabis users had decreased risk for total PUD (aPRR: 0.74[0.61-0.89]), duodenal PUD (0.48[0.35-0.60]) and PUD complications including hemorrhage (0.58[0.37-0.90]), perforation (0.66[0.51-0.87]), but not obstruction (1.75[0.51-5.98]). DISCUSSION/SIGNIFICANCE OF IMPACT: Cannabis usage is related to a reduced likelihood of having HPI in the community and also mitigate against having complicated presentations to the hospital. More translational studies are needed to illuminate the details of this relationship, given the high worldwide prevalence of both cannabis use and HPI.https://www.cambridge.org/core/product/identifier/S205986611900089X/type/journal_article |
| spellingShingle | Adeyinka Charles Adejumo Terence Ndonyi Bukong 3445 Cannabis use and risk of H. pylori infection; analysis of inpatients and residents of the US. Journal of Clinical and Translational Science |
| title | 3445 Cannabis use and risk of H. pylori infection; analysis of inpatients and residents of the US. |
| title_full | 3445 Cannabis use and risk of H. pylori infection; analysis of inpatients and residents of the US. |
| title_fullStr | 3445 Cannabis use and risk of H. pylori infection; analysis of inpatients and residents of the US. |
| title_full_unstemmed | 3445 Cannabis use and risk of H. pylori infection; analysis of inpatients and residents of the US. |
| title_short | 3445 Cannabis use and risk of H. pylori infection; analysis of inpatients and residents of the US. |
| title_sort | 3445 cannabis use and risk of h pylori infection analysis of inpatients and residents of the us |
| url | https://www.cambridge.org/core/product/identifier/S205986611900089X/type/journal_article |
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