Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate Cancer
(1) Objective: Our study investigated the prognostic value of tumor volume and location in prostate cancer patients who received radical prostatectomy (RP). (2) Methods: The prognostic significance of tumor volume and location, together with other clinical factors, was studied using 557 patients who...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/23/5823 |
| _version_ | 1797463573399601152 |
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| author | Haruki Baba Shinichi Sakamoto Xue Zhao Yasutaka Yamada Junryo Rii Ayumi Fujimoto Manato Kanesaka Nobuyoshi Takeuchi Tomokazu Sazuka Yusuke Imamura Koichiro Akakura Tomohiko Ichikawa |
| author_facet | Haruki Baba Shinichi Sakamoto Xue Zhao Yasutaka Yamada Junryo Rii Ayumi Fujimoto Manato Kanesaka Nobuyoshi Takeuchi Tomokazu Sazuka Yusuke Imamura Koichiro Akakura Tomohiko Ichikawa |
| author_sort | Haruki Baba |
| collection | DOAJ |
| description | (1) Objective: Our study investigated the prognostic value of tumor volume and location in prostate cancer patients who received radical prostatectomy (RP). (2) Methods: The prognostic significance of tumor volume and location, together with other clinical factors, was studied using 557 patients who received RP. (3) Results: The receiver operating characteristic (ROC) curve identified the optimal cutoff value of tumor volume as 2.8 cc for predicting biochemical recurrence (BCR). Cox regression analysis revealed that a tumor in the posterior area (<i>p</i> = 0.031), peripheral zone (<i>p</i> = 0.0472), and tumor volume ≥ 2.8 cc (<i>p</i> < 0.0001) were predictive factors in univariate analysis. After multivariate analysis, tumor volume ≥ 2.8 cc (<i>p</i> = 0.0225) was an independent predictive factor for BCR. Among them, a novel risk model was established using tumor volume and location in the posterior area and peripheral zone. The progression-free survival (PFS) of patients who met the three criteria (unfavorable group) was significantly worse than other groups (<i>p</i> ≤ 0.001). Furthermore, multivariate analysis showed that the unfavorable risk was an independent prognostic factor for BCR. The prognostic significance of our risk model was observed in low- to intermediate-risk patients, although it was not observed in high-risk patients. (4) Conclusion: Tumor volume (≥2.8 cc) and localization (posterior/peripheral zone) may be a novel prognostic factor in patients undergoing RP. |
| first_indexed | 2024-03-09T17:52:40Z |
| format | Article |
| id | doaj.art-c0eaa8c767de40d6ace00cf9d60514a6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:52:40Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c0eaa8c767de40d6ace00cf9d60514a62023-11-24T10:39:14ZengMDPI AGCancers2072-66942022-11-011423582310.3390/cancers14235823Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate CancerHaruki Baba0Shinichi Sakamoto1Xue Zhao2Yasutaka Yamada3Junryo Rii4Ayumi Fujimoto5Manato Kanesaka6Nobuyoshi Takeuchi7Tomokazu Sazuka8Yusuke Imamura9Koichiro Akakura10Tomohiko Ichikawa11Department of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, JapanDepartment of Urology, Japan Community Health-Care Organization Tokyo Shinjuku Medical Center, Tokyo 162-8543, JapanDepartment of Urology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan(1) Objective: Our study investigated the prognostic value of tumor volume and location in prostate cancer patients who received radical prostatectomy (RP). (2) Methods: The prognostic significance of tumor volume and location, together with other clinical factors, was studied using 557 patients who received RP. (3) Results: The receiver operating characteristic (ROC) curve identified the optimal cutoff value of tumor volume as 2.8 cc for predicting biochemical recurrence (BCR). Cox regression analysis revealed that a tumor in the posterior area (<i>p</i> = 0.031), peripheral zone (<i>p</i> = 0.0472), and tumor volume ≥ 2.8 cc (<i>p</i> < 0.0001) were predictive factors in univariate analysis. After multivariate analysis, tumor volume ≥ 2.8 cc (<i>p</i> = 0.0225) was an independent predictive factor for BCR. Among them, a novel risk model was established using tumor volume and location in the posterior area and peripheral zone. The progression-free survival (PFS) of patients who met the three criteria (unfavorable group) was significantly worse than other groups (<i>p</i> ≤ 0.001). Furthermore, multivariate analysis showed that the unfavorable risk was an independent prognostic factor for BCR. The prognostic significance of our risk model was observed in low- to intermediate-risk patients, although it was not observed in high-risk patients. (4) Conclusion: Tumor volume (≥2.8 cc) and localization (posterior/peripheral zone) may be a novel prognostic factor in patients undergoing RP.https://www.mdpi.com/2072-6694/14/23/5823tumor volumetumor locationprostate cancerbiochemical recurrenceprognostic factor |
| spellingShingle | Haruki Baba Shinichi Sakamoto Xue Zhao Yasutaka Yamada Junryo Rii Ayumi Fujimoto Manato Kanesaka Nobuyoshi Takeuchi Tomokazu Sazuka Yusuke Imamura Koichiro Akakura Tomohiko Ichikawa Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate Cancer Cancers tumor volume tumor location prostate cancer biochemical recurrence prognostic factor |
| title | Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate Cancer |
| title_full | Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate Cancer |
| title_fullStr | Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate Cancer |
| title_full_unstemmed | Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate Cancer |
| title_short | Tumor Location and a Tumor Volume over 2.8 cc Predict the Prognosis for Japanese Localized Prostate Cancer |
| title_sort | tumor location and a tumor volume over 2 8 cc predict the prognosis for japanese localized prostate cancer |
| topic | tumor volume tumor location prostate cancer biochemical recurrence prognostic factor |
| url | https://www.mdpi.com/2072-6694/14/23/5823 |
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