Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction?
Intracytoplasmic injection with testicular spermatozoa has become a routine treatment in fertility clinics. Spermatozoa can be recovered in half of patients with nonobstructive azoospermia. The use of immature germ cells for intracytoplasmic injection has been proposed for cases in which no spermato...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2013-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013001300017 |
| _version_ | 1811318515603341312 |
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| author | Veerle Vloeberghs Greta Verheyen Herman Tournaye |
| author_facet | Veerle Vloeberghs Greta Verheyen Herman Tournaye |
| author_sort | Veerle Vloeberghs |
| collection | DOAJ |
| description | Intracytoplasmic injection with testicular spermatozoa has become a routine treatment in fertility clinics. Spermatozoa can be recovered in half of patients with nonobstructive azoospermia. The use of immature germ cells for intracytoplasmic injection has been proposed for cases in which no spermatozoa can be retrieved. However, there are low pregnancy rates following intracytoplasmic injection using round spermatids from men with no elongated spermatids or spermatozoa in their testes. The in vitro culture of immature germ cells to more mature stages has been proposed as a means to improve this poor outcome. Several years after the introduction of intracytoplasmic injection with elongating and round spermatids, uncertainty remains as to whether this approach can be considered a safe treatment option. This review outlines the clinical and scientific data regarding intracytoplasmic injection using immature germ cells and in vitro matured germ cells. |
| first_indexed | 2024-04-13T12:27:18Z |
| format | Article |
| id | doaj.art-c0eb42911eef4ce3a81e2cf15d10968b |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T12:27:18Z |
| publishDate | 2013-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-c0eb42911eef4ce3a81e2cf15d10968b2022-12-22T02:46:59ZengElsevier EspañaClinics1807-59321980-53222013-01-0168151156Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction?Veerle VloeberghsGreta VerheyenHerman TournayeIntracytoplasmic injection with testicular spermatozoa has become a routine treatment in fertility clinics. Spermatozoa can be recovered in half of patients with nonobstructive azoospermia. The use of immature germ cells for intracytoplasmic injection has been proposed for cases in which no spermatozoa can be retrieved. However, there are low pregnancy rates following intracytoplasmic injection using round spermatids from men with no elongated spermatids or spermatozoa in their testes. The in vitro culture of immature germ cells to more mature stages has been proposed as a means to improve this poor outcome. Several years after the introduction of intracytoplasmic injection with elongating and round spermatids, uncertainty remains as to whether this approach can be considered a safe treatment option. This review outlines the clinical and scientific data regarding intracytoplasmic injection using immature germ cells and in vitro matured germ cells.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013001300017Round SpermatidElongating SpermatidElongated SpermatidICSIIn Vitro Maturation |
| spellingShingle | Veerle Vloeberghs Greta Verheyen Herman Tournaye Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction? Clinics Round Spermatid Elongating Spermatid Elongated Spermatid ICSI In Vitro Maturation |
| title | Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction? |
| title_full | Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction? |
| title_fullStr | Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction? |
| title_full_unstemmed | Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction? |
| title_short | Intracytoplasmic spermatid injection and in vitro maturation: fact or fiction? |
| title_sort | intracytoplasmic spermatid injection and in vitro maturation fact or fiction |
| topic | Round Spermatid Elongating Spermatid Elongated Spermatid ICSI In Vitro Maturation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013001300017 |
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