Oxidative Stress Markers and Modified Model for End-Stage Liver Disease Are Associated with Outcomes in Patients with Advanced Heart Failure Receiving Bridged Therapy with Continuous-Flow Left Ventricular Assist Devices
Left ventricular assist device (LVAD) is well established as an alternative treatment for end-stage heart failure (HF) patients. The aim of the study was to determine the prognostic value of oxidative stress markers and the modified Model for End-Stage Liver Disease (modMELD) in patients receiving b...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/11/1813 |
| _version_ | 1797511456364691456 |
|---|---|
| author | Bożena Szyguła-Jurkiewicz Wioletta Szczurek-Wasilewicz Mariusz Gąsior Izabela Copik Justyna Małyszek-Tumidajewicz Michał Skrzypek Ewa Romuk Michał Zembala Marian Zembala Piotr Przybyłowski |
| author_facet | Bożena Szyguła-Jurkiewicz Wioletta Szczurek-Wasilewicz Mariusz Gąsior Izabela Copik Justyna Małyszek-Tumidajewicz Michał Skrzypek Ewa Romuk Michał Zembala Marian Zembala Piotr Przybyłowski |
| author_sort | Bożena Szyguła-Jurkiewicz |
| collection | DOAJ |
| description | Left ventricular assist device (LVAD) is well established as an alternative treatment for end-stage heart failure (HF) patients. The aim of the study was to determine the prognostic value of oxidative stress markers and the modified Model for End-Stage Liver Disease (modMELD) in patients receiving bridged therapy with continuous-flow LVAD. We prospectively analyzed 36 end-stage HF patients who received LVAD therapy between 2015 and 2018. The total antioxidant capacity (TAC) and total oxidant status (TOS) were measured by the methods described by Erel. The oxidative stress index (OSI) was defined as the ratio of the TOS to TAC levels. The modMELD scores were calculated based on the serum bilirubin, creatinine, and albumin levels. The patients’ median age was 58 (50–63.0) years. During the 1.5-years follow-up, a major adverse cardiac event—MACE (death, stroke, or pump thrombosis) was observed in 17 patients (47.2%). The area under the receiver operating characteristics curves (AUCs) indicated a good prognostic power of TAC (AUC 0.7183 (0.5417–0.8948)), TOS (AUC 0.9149 (0.8205–0.9298)), OSI (AUC 0.9628 (0.9030–0.9821)), and modMELD (AUC 0.87 (0.7494–0.9905)) to predict a MACE. Oxidative stress markers serum concentrations, as well as the modMELD score, allow the identification of patients with a risk of MACE. |
| first_indexed | 2024-03-10T05:45:31Z |
| format | Article |
| id | doaj.art-c0ec5e23b6e24fd4848105f0108a8880 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:45:31Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-c0ec5e23b6e24fd4848105f0108a88802023-11-22T22:14:05ZengMDPI AGAntioxidants2076-39212021-11-011011181310.3390/antiox10111813Oxidative Stress Markers and Modified Model for End-Stage Liver Disease Are Associated with Outcomes in Patients with Advanced Heart Failure Receiving Bridged Therapy with Continuous-Flow Left Ventricular Assist DevicesBożena Szyguła-Jurkiewicz0Wioletta Szczurek-Wasilewicz1Mariusz Gąsior2Izabela Copik3Justyna Małyszek-Tumidajewicz4Michał Skrzypek5Ewa Romuk6Michał Zembala7Marian Zembala8Piotr Przybyłowski93rd Department of Cardiology, School of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandSilesian Center for Heart Diseases in Zabrze, 41-800 Zabrze, Poland3rd Department of Cardiology, School of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandSilesian Center for Heart Diseases in Zabrze, 41-800 Zabrze, PolandSilesian Center for Heart Diseases in Zabrze, 41-800 Zabrze, PolandDepartment of Biostatistics, School of Public Health in Bytom, Medical University of Silesia in Katowice, 40-055 Katowice, PolandDepartment of Biochemistry, School of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, PolandSilesian Center for Heart Diseases in Zabrze, 41-800 Zabrze, PolandSilesian Center for Heart Diseases in Zabrze, 41-800 Zabrze, PolandSilesian Center for Heart Diseases in Zabrze, 41-800 Zabrze, PolandLeft ventricular assist device (LVAD) is well established as an alternative treatment for end-stage heart failure (HF) patients. The aim of the study was to determine the prognostic value of oxidative stress markers and the modified Model for End-Stage Liver Disease (modMELD) in patients receiving bridged therapy with continuous-flow LVAD. We prospectively analyzed 36 end-stage HF patients who received LVAD therapy between 2015 and 2018. The total antioxidant capacity (TAC) and total oxidant status (TOS) were measured by the methods described by Erel. The oxidative stress index (OSI) was defined as the ratio of the TOS to TAC levels. The modMELD scores were calculated based on the serum bilirubin, creatinine, and albumin levels. The patients’ median age was 58 (50–63.0) years. During the 1.5-years follow-up, a major adverse cardiac event—MACE (death, stroke, or pump thrombosis) was observed in 17 patients (47.2%). The area under the receiver operating characteristics curves (AUCs) indicated a good prognostic power of TAC (AUC 0.7183 (0.5417–0.8948)), TOS (AUC 0.9149 (0.8205–0.9298)), OSI (AUC 0.9628 (0.9030–0.9821)), and modMELD (AUC 0.87 (0.7494–0.9905)) to predict a MACE. Oxidative stress markers serum concentrations, as well as the modMELD score, allow the identification of patients with a risk of MACE.https://www.mdpi.com/2076-3921/10/11/1813oxidative stressmodified model for end-stage liver diseaseheart failureleft ventricular assist device |
| spellingShingle | Bożena Szyguła-Jurkiewicz Wioletta Szczurek-Wasilewicz Mariusz Gąsior Izabela Copik Justyna Małyszek-Tumidajewicz Michał Skrzypek Ewa Romuk Michał Zembala Marian Zembala Piotr Przybyłowski Oxidative Stress Markers and Modified Model for End-Stage Liver Disease Are Associated with Outcomes in Patients with Advanced Heart Failure Receiving Bridged Therapy with Continuous-Flow Left Ventricular Assist Devices Antioxidants oxidative stress modified model for end-stage liver disease heart failure left ventricular assist device |
| title | Oxidative Stress Markers and Modified Model for End-Stage Liver Disease Are Associated with Outcomes in Patients with Advanced Heart Failure Receiving Bridged Therapy with Continuous-Flow Left Ventricular Assist Devices |
| title_full | Oxidative Stress Markers and Modified Model for End-Stage Liver Disease Are Associated with Outcomes in Patients with Advanced Heart Failure Receiving Bridged Therapy with Continuous-Flow Left Ventricular Assist Devices |
| title_fullStr | Oxidative Stress Markers and Modified Model for End-Stage Liver Disease Are Associated with Outcomes in Patients with Advanced Heart Failure Receiving Bridged Therapy with Continuous-Flow Left Ventricular Assist Devices |
| title_full_unstemmed | Oxidative Stress Markers and Modified Model for End-Stage Liver Disease Are Associated with Outcomes in Patients with Advanced Heart Failure Receiving Bridged Therapy with Continuous-Flow Left Ventricular Assist Devices |
| title_short | Oxidative Stress Markers and Modified Model for End-Stage Liver Disease Are Associated with Outcomes in Patients with Advanced Heart Failure Receiving Bridged Therapy with Continuous-Flow Left Ventricular Assist Devices |
| title_sort | oxidative stress markers and modified model for end stage liver disease are associated with outcomes in patients with advanced heart failure receiving bridged therapy with continuous flow left ventricular assist devices |
| topic | oxidative stress modified model for end-stage liver disease heart failure left ventricular assist device |
| url | https://www.mdpi.com/2076-3921/10/11/1813 |
| work_keys_str_mv | AT bozenaszygułajurkiewicz oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices AT wiolettaszczurekwasilewicz oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices AT mariuszgasior oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices AT izabelacopik oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices AT justynamałyszektumidajewicz oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices AT michałskrzypek oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices AT ewaromuk oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices AT michałzembala oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices AT marianzembala oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices AT piotrprzybyłowski oxidativestressmarkersandmodifiedmodelforendstageliverdiseaseareassociatedwithoutcomesinpatientswithadvancedheartfailurereceivingbridgedtherapywithcontinuousflowleftventricularassistdevices |