Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function
Background Epicardial adipose tissue (EAT) is in immediate apposition to the underlying myocardium and, therefore, has the potential to influence myocardial systolic and diastolic function or myocardial geometry, through paracrine or compressive mechanical effects. We aimed to review the association...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.118.009975 |
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| author | Nitesh Nerlekar Rahul G. Muthalaly Nathan Wong Udit Thakur Dennis T. L. Wong Adam J. Brown Thomas H. Marwick |
| author_facet | Nitesh Nerlekar Rahul G. Muthalaly Nathan Wong Udit Thakur Dennis T. L. Wong Adam J. Brown Thomas H. Marwick |
| author_sort | Nitesh Nerlekar |
| collection | DOAJ |
| description | Background Epicardial adipose tissue (EAT) is in immediate apposition to the underlying myocardium and, therefore, has the potential to influence myocardial systolic and diastolic function or myocardial geometry, through paracrine or compressive mechanical effects. We aimed to review the association between volumetric EAT and markers of myocardial function and geometry. Methods and Results PubMed, Medline, and Embase were searched from inception to May 2018. Studies were included only if complete EAT volume or mass was reported and related to a measure of myocardial function and/or geometry. Meta‐analysis and meta‐regression were used to evaluate the weighted mean difference of EAT in patients with and without diastolic dysfunction. Heterogeneity of data reporting precluded meta‐analysis for systolic and geometric associations. In the 22 studies included in the analysis, there was a significant correlation with increasing EAT and presence of diastolic dysfunction and mean e′ (average mitral annular tissue Doppler velocity) and E/e′ (early inflow / annular velocity ratio) but not E/A (ratio of peak early (E) and late (A) transmitral inflow velocities), independent of adiposity measures. There was a greater EAT in patients with diastolic dysfunction (weighted mean difference, 24.43 mL; 95% confidence interval, 18.5–30.4 mL; P<0.001), and meta‐regression confirmed the association of increasing EAT with diastolic dysfunction (P=0.001). Reported associations of increasing EAT with increasing left ventricular mass and the inverse correlation of EAT with left ventricular ejection fraction were inconsistent, and not independent from other adiposity measures. Conclusions EAT is associated with diastolic function, independent of other influential variables. EAT is an effect modifier for chamber size but not systolic function. |
| first_indexed | 2024-12-22T20:48:38Z |
| format | Article |
| id | doaj.art-c0eeb037b2bd48f5b86308dc00e44240 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-22T20:48:38Z |
| publishDate | 2018-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-c0eeb037b2bd48f5b86308dc00e442402022-12-21T18:13:09ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802018-12-0172310.1161/JAHA.118.009975Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and FunctionNitesh Nerlekar0Rahul G. Muthalaly1Nathan Wong2Udit Thakur3Dennis T. L. Wong4Adam J. Brown5Thomas H. Marwick6Monash Cardiovascular Research Centre Department of Medicine (Monash Medical Centre), Monash University and Monash Heart Monash Health Clayton AustraliaMonash Cardiovascular Research Centre Department of Medicine (Monash Medical Centre), Monash University and Monash Heart Monash Health Clayton AustraliaMonash Cardiovascular Research Centre Department of Medicine (Monash Medical Centre), Monash University and Monash Heart Monash Health Clayton AustraliaMonash Cardiovascular Research Centre Department of Medicine (Monash Medical Centre), Monash University and Monash Heart Monash Health Clayton AustraliaMonash Cardiovascular Research Centre Department of Medicine (Monash Medical Centre), Monash University and Monash Heart Monash Health Clayton AustraliaMonash Cardiovascular Research Centre Department of Medicine (Monash Medical Centre), Monash University and Monash Heart Monash Health Clayton AustraliaBaker Heart and Diabetes Institute Melbourne AustraliaBackground Epicardial adipose tissue (EAT) is in immediate apposition to the underlying myocardium and, therefore, has the potential to influence myocardial systolic and diastolic function or myocardial geometry, through paracrine or compressive mechanical effects. We aimed to review the association between volumetric EAT and markers of myocardial function and geometry. Methods and Results PubMed, Medline, and Embase were searched from inception to May 2018. Studies were included only if complete EAT volume or mass was reported and related to a measure of myocardial function and/or geometry. Meta‐analysis and meta‐regression were used to evaluate the weighted mean difference of EAT in patients with and without diastolic dysfunction. Heterogeneity of data reporting precluded meta‐analysis for systolic and geometric associations. In the 22 studies included in the analysis, there was a significant correlation with increasing EAT and presence of diastolic dysfunction and mean e′ (average mitral annular tissue Doppler velocity) and E/e′ (early inflow / annular velocity ratio) but not E/A (ratio of peak early (E) and late (A) transmitral inflow velocities), independent of adiposity measures. There was a greater EAT in patients with diastolic dysfunction (weighted mean difference, 24.43 mL; 95% confidence interval, 18.5–30.4 mL; P<0.001), and meta‐regression confirmed the association of increasing EAT with diastolic dysfunction (P=0.001). Reported associations of increasing EAT with increasing left ventricular mass and the inverse correlation of EAT with left ventricular ejection fraction were inconsistent, and not independent from other adiposity measures. Conclusions EAT is associated with diastolic function, independent of other influential variables. EAT is an effect modifier for chamber size but not systolic function.https://www.ahajournals.org/doi/10.1161/JAHA.118.009975diastolic functionepicardial fatsystolic dysfunction |
| spellingShingle | Nitesh Nerlekar Rahul G. Muthalaly Nathan Wong Udit Thakur Dennis T. L. Wong Adam J. Brown Thomas H. Marwick Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease diastolic function epicardial fat systolic dysfunction |
| title | Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function |
| title_full | Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function |
| title_fullStr | Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function |
| title_full_unstemmed | Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function |
| title_short | Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function |
| title_sort | association of volumetric epicardial adipose tissue quantification and cardiac structure and function |
| topic | diastolic function epicardial fat systolic dysfunction |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.118.009975 |
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