Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway.
Mevalonate is metabolized by a sterol-forming and a non-sterol-forming, also called the ''shunt'', pathway. Effects of estrogen and testosterone administration on the shunt activity were examined in male and female Wistar and Sprague-Dawley rats. Shunt activity was determined in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1983-09-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520379001 |
| _version_ | 1818726928974086144 |
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| author | P S Brady R F Scofield S Mann B R Landau |
| author_facet | P S Brady R F Scofield S Mann B R Landau |
| author_sort | P S Brady |
| collection | DOAJ |
| description | Mevalonate is metabolized by a sterol-forming and a non-sterol-forming, also called the ''shunt'', pathway. Effects of estrogen and testosterone administration on the shunt activity were examined in male and female Wistar and Sprague-Dawley rats. Shunt activity was determined in vivo from the yield of expired 14CO2 following [5-14C]mevalonate injection. Total mevalonate utilized was determined from the yield of expired 14CO2 following [1-14C]mevalonate injection. In the female, about 45% of mevalonate appears to be metabolized via the shunt, and in the male about 20%. This difference between male and female rats is dependent on both testosterone and estrogen, and apparently on testosterone to a greater extent. Thus estrogen treatment produced a 20-35% increase in shunt activity over castrated controls, while castration of males without hormonal treatment resulted in about a 50% increase in shunt activity, and testosterone administration returned castrated male and female shunt activity to that of intact males, or nearly so. Light/dark cycle had no effect in vivo on shunt activity, but may be critical in demonstrating sex differences in shunt activity in kidney slices. |
| first_indexed | 2024-12-17T22:06:00Z |
| format | Article |
| id | doaj.art-c0f07406fa4b42489ba1e901297d250c |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T22:06:00Z |
| publishDate | 1983-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-c0f07406fa4b42489ba1e901297d250c2022-12-21T21:30:51ZengElsevierJournal of Lipid Research0022-22751983-09-0124911681175Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway.P S BradyR F ScofieldS MannB R LandauMevalonate is metabolized by a sterol-forming and a non-sterol-forming, also called the ''shunt'', pathway. Effects of estrogen and testosterone administration on the shunt activity were examined in male and female Wistar and Sprague-Dawley rats. Shunt activity was determined in vivo from the yield of expired 14CO2 following [5-14C]mevalonate injection. Total mevalonate utilized was determined from the yield of expired 14CO2 following [1-14C]mevalonate injection. In the female, about 45% of mevalonate appears to be metabolized via the shunt, and in the male about 20%. This difference between male and female rats is dependent on both testosterone and estrogen, and apparently on testosterone to a greater extent. Thus estrogen treatment produced a 20-35% increase in shunt activity over castrated controls, while castration of males without hormonal treatment resulted in about a 50% increase in shunt activity, and testosterone administration returned castrated male and female shunt activity to that of intact males, or nearly so. Light/dark cycle had no effect in vivo on shunt activity, but may be critical in demonstrating sex differences in shunt activity in kidney slices.http://www.sciencedirect.com/science/article/pii/S0022227520379001 |
| spellingShingle | P S Brady R F Scofield S Mann B R Landau Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. Journal of Lipid Research |
| title | Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. |
| title_full | Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. |
| title_fullStr | Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. |
| title_full_unstemmed | Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. |
| title_short | Effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway. |
| title_sort | effects of estrogen and testosterone on the metabolism of mevalonate by the shunt pathway |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520379001 |
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