p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer

p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the pathogenesis of HNSCC. Physiologically, p63 affects metab...

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Bibliographic Details
Main Authors: Angela Cappello, Giulia Tosetti, Artem Smirnov, Carlo Ganini, Xue Yang, Yufang Shi, Ying Wang, Gerry Melino, Francesca Bernassola, Eleonora Candi
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Biology Direct
Subjects:
Head and neck cancer
p53 family
p63
Serine
One carbon metabolism
Online Access:https://doi.org/10.1186/s13062-023-00426-1

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