Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients
Telomere length (TL) is associated with cardiovascular disease (CVD) and cancer. Obstructive sleep apnea (OSA) is also linked to higher risk of CVD and cancer, and to TL. We investigated the association between TL and risk of major adverse cardiac events (MACE) and cancer in OSA patients. We studied...
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MDPI AG
2019-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/5/381 |
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| author | Katarzyna Polonis Sreeja Sompalli Christiane Becari Jiang Xie Naima Covassin Phillip J Schulte Brooke R Druliner Ruth A Johnson Krzysztof Narkiewicz Lisa A Boardman Prachi Singh Virend K Somers |
| author_facet | Katarzyna Polonis Sreeja Sompalli Christiane Becari Jiang Xie Naima Covassin Phillip J Schulte Brooke R Druliner Ruth A Johnson Krzysztof Narkiewicz Lisa A Boardman Prachi Singh Virend K Somers |
| author_sort | Katarzyna Polonis |
| collection | DOAJ |
| description | Telomere length (TL) is associated with cardiovascular disease (CVD) and cancer. Obstructive sleep apnea (OSA) is also linked to higher risk of CVD and cancer, and to TL. We investigated the association between TL and risk of major adverse cardiac events (MACE) and cancer in OSA patients. We studied 210 individuals undergoing sleep-related studies between 2000 and 2007. Baseline characteristics and follow-up data (available in 164 subjects) were obtained from clinic records. Incidence rates were calculated for the entire group and by OSA status. Hazard ratios were calculated to estimate effects of OSA and TL on risk of MACE and cancer. In total, 32 individuals (20%) developed MACE and/or cancer during 12.7-year follow-up. The OSA group had a higher likelihood of cancer (16.0 vs. 4.9 events per 1000 person-years, <i>P</i> = 0.044) but no clear evidence of an elevated incidence of MACE (10.8 vs. 4.8 events per 1000 person-years, <i>P</i> = 0.293) compared to the non-OSA group. There was no association between TL and MACE- (HR = 1.01, 95% CI 0.78−1.28), or cancer-risk (HR = 1.18, 95% CI 0.96−1.43). Our study warrants further investigation of any modulating effect of OSA on TL and the risk of MACE and cancer. |
| first_indexed | 2024-03-12T06:32:22Z |
| format | Article |
| id | doaj.art-c0f3b47149414087b98bbfb783c05f01 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:32:22Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-c0f3b47149414087b98bbfb783c05f012023-09-03T01:32:51ZengMDPI AGCells2073-44092019-04-018538110.3390/cells8050381cells8050381Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea PatientsKatarzyna Polonis0Sreeja Sompalli1Christiane Becari2Jiang Xie3Naima Covassin4Phillip J Schulte5Brooke R Druliner6Ruth A Johnson7Krzysztof Narkiewicz8Lisa A Boardman9Prachi Singh10Virend K Somers11Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55 905, USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55 905, USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55 905, USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55 905, USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55 905, USADivision of Biomedical Statistics and Informatics, Mayo Clinic, MN55 905, USADivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55 905, USADivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55 905, USADepartment of Hypertension and Diabetology, Faculty of Medicine, Medical University of Gdansk, 80 210 Gdansk, PolandDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55 905, USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55 905, USADepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55 905, USATelomere length (TL) is associated with cardiovascular disease (CVD) and cancer. Obstructive sleep apnea (OSA) is also linked to higher risk of CVD and cancer, and to TL. We investigated the association between TL and risk of major adverse cardiac events (MACE) and cancer in OSA patients. We studied 210 individuals undergoing sleep-related studies between 2000 and 2007. Baseline characteristics and follow-up data (available in 164 subjects) were obtained from clinic records. Incidence rates were calculated for the entire group and by OSA status. Hazard ratios were calculated to estimate effects of OSA and TL on risk of MACE and cancer. In total, 32 individuals (20%) developed MACE and/or cancer during 12.7-year follow-up. The OSA group had a higher likelihood of cancer (16.0 vs. 4.9 events per 1000 person-years, <i>P</i> = 0.044) but no clear evidence of an elevated incidence of MACE (10.8 vs. 4.8 events per 1000 person-years, <i>P</i> = 0.293) compared to the non-OSA group. There was no association between TL and MACE- (HR = 1.01, 95% CI 0.78−1.28), or cancer-risk (HR = 1.18, 95% CI 0.96−1.43). Our study warrants further investigation of any modulating effect of OSA on TL and the risk of MACE and cancer.https://www.mdpi.com/2073-4409/8/5/381obstructive sleep apneatelomere lengthmajor adverse cardiac eventscancer |
| spellingShingle | Katarzyna Polonis Sreeja Sompalli Christiane Becari Jiang Xie Naima Covassin Phillip J Schulte Brooke R Druliner Ruth A Johnson Krzysztof Narkiewicz Lisa A Boardman Prachi Singh Virend K Somers Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients Cells obstructive sleep apnea telomere length major adverse cardiac events cancer |
| title | Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients |
| title_full | Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients |
| title_fullStr | Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients |
| title_full_unstemmed | Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients |
| title_short | Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients |
| title_sort | telomere length and risk of major adverse cardiac events and cancer in obstructive sleep apnea patients |
| topic | obstructive sleep apnea telomere length major adverse cardiac events cancer |
| url | https://www.mdpi.com/2073-4409/8/5/381 |
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