Targeting Cytokine Signals to Enhance γδT Cell-Based Cancer Immunotherapy
γδT cells represent a small percentage of T cells in circulation but are found in large numbers in certain organs. They are considered to be innate immune cells that can exert cytotoxic functions on target cells without MHC restriction. Moreover, γδT cells contribute to adaptive immune response via...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.914839/full |
| _version_ | 1811335699780075520 |
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| author | Yuan Song Yuan Song Yonghao Liu Yonghao Liu Huey Yee Teo Huey Yee Teo Haiyan Liu Haiyan Liu |
| author_facet | Yuan Song Yuan Song Yonghao Liu Yonghao Liu Huey Yee Teo Huey Yee Teo Haiyan Liu Haiyan Liu |
| author_sort | Yuan Song |
| collection | DOAJ |
| description | γδT cells represent a small percentage of T cells in circulation but are found in large numbers in certain organs. They are considered to be innate immune cells that can exert cytotoxic functions on target cells without MHC restriction. Moreover, γδT cells contribute to adaptive immune response via regulating other immune cells. Under the influence of cytokines, γδT cells can be polarized to different subsets in the tumor microenvironment. In this review, we aimed to summarize the current understanding of antigen recognition by γδT cells, and the immune regulation mediated by γδT cells in the tumor microenvironment. More importantly, we depicted the polarization and plasticity of γδT cells in the presence of different cytokines and their combinations, which provided the basis for γδT cell-based cancer immunotherapy targeting cytokine signals. |
| first_indexed | 2024-04-13T17:29:05Z |
| format | Article |
| id | doaj.art-c0f5800e9cca4f64935aed838097f227 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T17:29:05Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-c0f5800e9cca4f64935aed838097f2272022-12-22T02:37:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.914839914839Targeting Cytokine Signals to Enhance γδT Cell-Based Cancer ImmunotherapyYuan Song0Yuan Song1Yonghao Liu2Yonghao Liu3Huey Yee Teo4Huey Yee Teo5Haiyan Liu6Haiyan Liu7Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, SingaporeImmunology Translational Research Program and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, SingaporeImmunology Translational Research Program and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, SingaporeImmunology Translational Research Program and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeImmunology Programme, Life Sciences Institute, National University of Singapore, Singapore, SingaporeImmunology Translational Research Program and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeγδT cells represent a small percentage of T cells in circulation but are found in large numbers in certain organs. They are considered to be innate immune cells that can exert cytotoxic functions on target cells without MHC restriction. Moreover, γδT cells contribute to adaptive immune response via regulating other immune cells. Under the influence of cytokines, γδT cells can be polarized to different subsets in the tumor microenvironment. In this review, we aimed to summarize the current understanding of antigen recognition by γδT cells, and the immune regulation mediated by γδT cells in the tumor microenvironment. More importantly, we depicted the polarization and plasticity of γδT cells in the presence of different cytokines and their combinations, which provided the basis for γδT cell-based cancer immunotherapy targeting cytokine signals.https://www.frontiersin.org/articles/10.3389/fimmu.2022.914839/fullγδT cellcytokinecancerimmunotherapycellular therapy |
| spellingShingle | Yuan Song Yuan Song Yonghao Liu Yonghao Liu Huey Yee Teo Huey Yee Teo Haiyan Liu Haiyan Liu Targeting Cytokine Signals to Enhance γδT Cell-Based Cancer Immunotherapy Frontiers in Immunology γδT cell cytokine cancer immunotherapy cellular therapy |
| title | Targeting Cytokine Signals to Enhance γδT Cell-Based Cancer Immunotherapy |
| title_full | Targeting Cytokine Signals to Enhance γδT Cell-Based Cancer Immunotherapy |
| title_fullStr | Targeting Cytokine Signals to Enhance γδT Cell-Based Cancer Immunotherapy |
| title_full_unstemmed | Targeting Cytokine Signals to Enhance γδT Cell-Based Cancer Immunotherapy |
| title_short | Targeting Cytokine Signals to Enhance γδT Cell-Based Cancer Immunotherapy |
| title_sort | targeting cytokine signals to enhance γδt cell based cancer immunotherapy |
| topic | γδT cell cytokine cancer immunotherapy cellular therapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.914839/full |
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