Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H

Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H

Abstract Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and dhps (Pfdhps) genes confer resistance to pyrimethamine and sulfadoxine,...

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Bibliographic Details
Main Authors: M. Andreína Pacheco, Kristan A. Schneider, Qiuying Cheng, Elly O. Munde, Caroline Ndege, Clinton Onyango, Evans Raballah, Samuel B. Anyona, Collins Ouma, Douglas J. Perkins, Ananias A. Escalante
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Malaria Journal
Subjects:
Drug resistance genes
Dhfr
Dhps
k13 gene
SP resistance
Plasmodium falciparum
Online Access:http://link.springer.com/article/10.1186/s12936-020-03454-8

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