Low-Energy Transcranial Navigation-Guided Focused Ultrasound for Neuropathic Pain: An Exploratory Study
Neuromodulation using high-energy focused ultrasound (FUS) has recently been developed for various neurological disorders, including tremors, epilepsy, and neuropathic pain. We investigated the safety and efficacy of low-energy FUS for patients with chronic neuropathic pain. We conducted a prospecti...
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MDPI AG
2023-10-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/10/1433 |
| _version_ | 1797574534793003008 |
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| author | Dong Hoon Shin Seong Son Eun Young Kim |
| author_facet | Dong Hoon Shin Seong Son Eun Young Kim |
| author_sort | Dong Hoon Shin |
| collection | DOAJ |
| description | Neuromodulation using high-energy focused ultrasound (FUS) has recently been developed for various neurological disorders, including tremors, epilepsy, and neuropathic pain. We investigated the safety and efficacy of low-energy FUS for patients with chronic neuropathic pain. We conducted a prospective single-arm trial with 3-month follow-up using new transcranial, navigation-guided, focused ultrasound (tcNgFUS) technology to stimulate the anterior cingulate cortex. Eleven patients underwent FUS with a frequency of 250 kHz and spatial-peak temporal-average intensity of 0.72 W/cm<sup>2</sup>. A clinical survey based on the visual analog scale of pain and a brief pain inventory (BPI) was performed during the study period. The average age was 60.55 ± 13.18 years-old with a male-to-female ratio of 6:5. The median current pain decreased from 10.0 to 7.0 (<i>p</i> = 0.021), median average pain decreased from 8.5 to 6.0 (<i>p</i> = 0.027), and median maximum pain decreased from 10.0 to 8.0 (<i>p</i> = 0.008) at 4 weeks after treatment. Additionally, the sum of daily life interference based on BPI was improved from 59.00 ± 11.66 to 51.91 ± 9.18 (<i>p</i> = 0.021). There were no side effects such as burns, headaches, or seizures, and no significant changes in follow-up brain magnetic resonance imaging. Low-energy tcNgFUS could be a safe and noninvasive neuromodulation technique for the treatment of chronic neuropathic pain |
| first_indexed | 2024-03-10T21:23:50Z |
| format | Article |
| id | doaj.art-c0f7d67fe1e44aacbe6d10097fd91d90 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T21:23:50Z |
| publishDate | 2023-10-01 |
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| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-c0f7d67fe1e44aacbe6d10097fd91d902023-11-19T15:52:52ZengMDPI AGBrain Sciences2076-34252023-10-011310143310.3390/brainsci13101433Low-Energy Transcranial Navigation-Guided Focused Ultrasound for Neuropathic Pain: An Exploratory StudyDong Hoon Shin0Seong Son1Eun Young Kim2Department of Neurology, Gachon University Gil Medical Center, Incheon 21565, Republic of KoreaDepartment of Neurosurgery, Gachon University Gil Medical Center, Incheon 21565, Republic of KoreaDepartment of Neurosurgery, Gachon University Gil Medical Center, Incheon 21565, Republic of KoreaNeuromodulation using high-energy focused ultrasound (FUS) has recently been developed for various neurological disorders, including tremors, epilepsy, and neuropathic pain. We investigated the safety and efficacy of low-energy FUS for patients with chronic neuropathic pain. We conducted a prospective single-arm trial with 3-month follow-up using new transcranial, navigation-guided, focused ultrasound (tcNgFUS) technology to stimulate the anterior cingulate cortex. Eleven patients underwent FUS with a frequency of 250 kHz and spatial-peak temporal-average intensity of 0.72 W/cm<sup>2</sup>. A clinical survey based on the visual analog scale of pain and a brief pain inventory (BPI) was performed during the study period. The average age was 60.55 ± 13.18 years-old with a male-to-female ratio of 6:5. The median current pain decreased from 10.0 to 7.0 (<i>p</i> = 0.021), median average pain decreased from 8.5 to 6.0 (<i>p</i> = 0.027), and median maximum pain decreased from 10.0 to 8.0 (<i>p</i> = 0.008) at 4 weeks after treatment. Additionally, the sum of daily life interference based on BPI was improved from 59.00 ± 11.66 to 51.91 ± 9.18 (<i>p</i> = 0.021). There were no side effects such as burns, headaches, or seizures, and no significant changes in follow-up brain magnetic resonance imaging. Low-energy tcNgFUS could be a safe and noninvasive neuromodulation technique for the treatment of chronic neuropathic painhttps://www.mdpi.com/2076-3425/13/10/1433anterior cingulate cortexdeep brain stimulationneuropathic painpercutaneous electrical neuromodulationultrasonic therapy |
| spellingShingle | Dong Hoon Shin Seong Son Eun Young Kim Low-Energy Transcranial Navigation-Guided Focused Ultrasound for Neuropathic Pain: An Exploratory Study Brain Sciences anterior cingulate cortex deep brain stimulation neuropathic pain percutaneous electrical neuromodulation ultrasonic therapy |
| title | Low-Energy Transcranial Navigation-Guided Focused Ultrasound for Neuropathic Pain: An Exploratory Study |
| title_full | Low-Energy Transcranial Navigation-Guided Focused Ultrasound for Neuropathic Pain: An Exploratory Study |
| title_fullStr | Low-Energy Transcranial Navigation-Guided Focused Ultrasound for Neuropathic Pain: An Exploratory Study |
| title_full_unstemmed | Low-Energy Transcranial Navigation-Guided Focused Ultrasound for Neuropathic Pain: An Exploratory Study |
| title_short | Low-Energy Transcranial Navigation-Guided Focused Ultrasound for Neuropathic Pain: An Exploratory Study |
| title_sort | low energy transcranial navigation guided focused ultrasound for neuropathic pain an exploratory study |
| topic | anterior cingulate cortex deep brain stimulation neuropathic pain percutaneous electrical neuromodulation ultrasonic therapy |
| url | https://www.mdpi.com/2076-3425/13/10/1433 |
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