A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1

A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1

MALDI-TOF MS is a powerful analytical technique that provides a fast and label-free readout for in vitro assays in the high-throughput screening (HTS) environment. Here, we describe the development of a novel, HTS compatible, MALDI-TOF MS-based drug discovery assay for the endoplasmic reticulum amin...

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Bibliographic Details
Main Authors: Leonie Müller, Amy K Burton, Chloe L Tayler, James E Rowedder, Jonathan P Hutchinson, Simon Peace, Julie M Quayle, Melanie V Leveridge, Roland S Annan, Matthias Trost, Rachel E Peltier-Heap, Maria Emilia Dueñas
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:SLAS Discovery
Subjects:
MALDI-TOF MS
High-throughput screening
Drug discovery
Mass spectrometry
Endoplasmic reticulum aminopeptidase 1
Major histocompatibility complex
Online Access:http://www.sciencedirect.com/science/article/pii/S247255522213707X

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