Chemical Synthesis, Safety and Efficacy of Antihypertensive Candidate Drug 221s (2,9)

Chemical Synthesis, Safety and Efficacy of Antihypertensive Candidate Drug 221s (2,9)

Hypertension is the main risk factor of cardiovascular and cerebrovascular diseases. In this paper, a novel compound known as 221s (2,9), which includes tanshinol, borneol and a mother nucleus of ACEI, was synthesized by condensation esterification, deprotection, amidation, deprotection, and amidati...

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Bibliographic Details
Main Authors: Bei Qin, Lili Yu, Rong Wang, Yimei Tang, Yunmei Chen, Nana Wang, Yixin Zhang, Xiong Tan, Kuan Yang, Bo Zhang, Maofang He, Yuzhen Zhang, Yaqi Hu
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
ACEI
tanshinol
borneol
antihypertensive
RAAS
Online Access:https://www.mdpi.com/1420-3049/28/13/4975

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