Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation

Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation

Summary: Postsynaptic density protein 95 is a key scaffolding protein in the postsynaptic density of excitatory glutamatergic neurons, organizing signaling complexes primarily via its three PSD-95/Discs-large/Zona occludens domains. PSD-95 is regulated by phosphorylation, but technical challenges ha...

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Bibliographic Details
Main Authors: Maria Vistrup-Parry, Xudong Chen, Thea L. Johansen, Sofie Bach, Sara C. Buch-Larsen, Christian R.O. Bartling, Chenxue Ma, Louise S. Clemmensen, Michael L. Nielsen, Mingjie Zhang, Kristian Strømgaard
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:iScience
Subjects:
Biochemistry
Biomolecules
Protein structure aspects
Biophysics
Biophysical chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221012372

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