Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots
The timely diagnosis of cancer represents the best chance to increase treatment success and to reduce cancer deaths. Nanomaterials-based biosensors containing graphene quantum dots (GQDs) as a sensing platform show great promise in the early and sensitive detection of cancer biomarkers, due to their...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/13/3194 |
| _version_ | 1797411923023626240 |
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| author | Daniela Iannazzo Claudia Espro Consuelo Celesti Angelo Ferlazzo Giovanni Neri |
| author_facet | Daniela Iannazzo Claudia Espro Consuelo Celesti Angelo Ferlazzo Giovanni Neri |
| author_sort | Daniela Iannazzo |
| collection | DOAJ |
| description | The timely diagnosis of cancer represents the best chance to increase treatment success and to reduce cancer deaths. Nanomaterials-based biosensors containing graphene quantum dots (GQDs) as a sensing platform show great promise in the early and sensitive detection of cancer biomarkers, due to their unique chemical and physical properties, large surface area and ease of functionalization with different biomolecules able to recognize relevant cancer biomarkers. In this review, we report different advanced strategies for the synthesis and functionalization of GQDs with different agents able to selectively recognize and convert into a signal specific cancer biomarkers such as antigens, enzymes, hormones, proteins, cancer related byproducts, biomolecules exposed on the surface of cancer cells and changes in pH. The developed optical, electrochemical and chemiluminescent biosensors based on GQDs have been shown to ensure the effective diagnosis of several cancer diseases as well as the possibility to evaluate the effectiveness of anticancer therapy. The wide linear range of detection and low detection limits recorded for most of the reported biosensors highlight their great potential in clinics for the diagnosis and management of cancer. |
| first_indexed | 2024-03-09T04:53:22Z |
| format | Article |
| id | doaj.art-c0fa7a8fa3db485a859220fbbf782846 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T04:53:22Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c0fa7a8fa3db485a859220fbbf7828462023-12-03T13:08:22ZengMDPI AGCancers2072-66942021-06-011313319410.3390/cancers13133194Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum DotsDaniela Iannazzo0Claudia Espro1Consuelo Celesti2Angelo Ferlazzo3Giovanni Neri4Department of Engineering, University of Messina, Contrada Di Dio, 98166 Messina, ItalyDepartment of Engineering, University of Messina, Contrada Di Dio, 98166 Messina, ItalyDepartment of Engineering, University of Messina, Contrada Di Dio, 98166 Messina, ItalyDepartment of Engineering, University of Messina, Contrada Di Dio, 98166 Messina, ItalyDepartment of Engineering, University of Messina, Contrada Di Dio, 98166 Messina, ItalyThe timely diagnosis of cancer represents the best chance to increase treatment success and to reduce cancer deaths. Nanomaterials-based biosensors containing graphene quantum dots (GQDs) as a sensing platform show great promise in the early and sensitive detection of cancer biomarkers, due to their unique chemical and physical properties, large surface area and ease of functionalization with different biomolecules able to recognize relevant cancer biomarkers. In this review, we report different advanced strategies for the synthesis and functionalization of GQDs with different agents able to selectively recognize and convert into a signal specific cancer biomarkers such as antigens, enzymes, hormones, proteins, cancer related byproducts, biomolecules exposed on the surface of cancer cells and changes in pH. The developed optical, electrochemical and chemiluminescent biosensors based on GQDs have been shown to ensure the effective diagnosis of several cancer diseases as well as the possibility to evaluate the effectiveness of anticancer therapy. The wide linear range of detection and low detection limits recorded for most of the reported biosensors highlight their great potential in clinics for the diagnosis and management of cancer.https://www.mdpi.com/2072-6694/13/13/3194graphene quantum dotscancer diagnosiscancer biomarkersbiosensors |
| spellingShingle | Daniela Iannazzo Claudia Espro Consuelo Celesti Angelo Ferlazzo Giovanni Neri Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots Cancers graphene quantum dots cancer diagnosis cancer biomarkers biosensors |
| title | Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots |
| title_full | Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots |
| title_fullStr | Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots |
| title_full_unstemmed | Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots |
| title_short | Smart Biosensors for Cancer Diagnosis Based on Graphene Quantum Dots |
| title_sort | smart biosensors for cancer diagnosis based on graphene quantum dots |
| topic | graphene quantum dots cancer diagnosis cancer biomarkers biosensors |
| url | https://www.mdpi.com/2072-6694/13/13/3194 |
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